ID S9VHG2_9TRYP Unreviewed; 405 AA.
AC S9VHG2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=argininosuccinate synthase {ECO:0000256|ARBA:ARBA00012286};
DE EC=6.3.4.5 {ECO:0000256|ARBA:ARBA00012286};
DE AltName: Full=Citrulline--aspartate ligase {ECO:0000256|ARBA:ARBA00029916};
GN ORFNames=ADEAN_000662500 {ECO:0000313|EMBL:CAD2219132.1};
OS Angomonas deanei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Angomonas.
OX NCBI_TaxID=59799 {ECO:0000313|EMBL:AGT02467.1};
RN [1] {ECO:0000313|EMBL:AGT02467.1}
RP NUCLEOTIDE SEQUENCE.
RA Alves J.M.P., Klein C., Maia da Silva F., Costa Martins A.G., Serrano M.G.,
RA Buck G.A., Vasconcelos A.T.R., France-Sagot M., Teixeira M.M.G.,
RA Motta M.C.M., Camargo E.P.;
RT "Genomic Cooperation Between Trypanosomatids and Their Bacterial
RT Endosymbionts in the Synthesis of Essential Amino Acids Heavily Influenced
RT by Multiple Lateral Gene Transfer Events.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAD2219132.1, ECO:0000313|Proteomes:UP000515908}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Crithidia deanei Carvalho {ECO:0000313|EMBL:CAD2219132.1}, and
RC Crithidia deanei Carvalho (ATCC PRA-265)
RC {ECO:0000313|Proteomes:UP000515908};
RA Newling K., Davey J., Forrester S.;
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 2/3.
CC {ECO:0000256|ARBA:ARBA00004967}.
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DR EMBL; KC503301; AGT02467.1; -; Genomic_DNA.
DR EMBL; LR877157; CAD2219132.1; -; Genomic_DNA.
DR AlphaFoldDB; S9VHG2; -.
DR EnsemblProtists; EPY39150; EPY39150; AGDE_04779.
DR EnsemblProtists; EPY40308; EPY40308; AGDE_03620.
DR VEuPathDB; TriTrypDB:ADEAN_000662500; -.
DR OrthoDB; 350199at2759; -.
DR UniPathway; UPA00068; UER00113.
DR Proteomes; UP000515908; Chromosome 13.
DR GO; GO:0004055; F:argininosuccinate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01999; Argininosuccinate_Synthase; 1.
DR Gene3D; 3.90.1260.10; Argininosuccinate synthetase, chain A, domain 2; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.20.5.470; Single helix bin; 1.
DR HAMAP; MF_00005; Arg_succ_synth_type1; 1.
DR InterPro; IPR048268; Arginosuc_syn_C.
DR InterPro; IPR048267; Arginosuc_syn_N.
DR InterPro; IPR001518; Arginosuc_synth.
DR InterPro; IPR018223; Arginosuc_synth_CS.
DR InterPro; IPR023434; Arginosuc_synth_type_1_subfam.
DR InterPro; IPR024074; AS_cat/multimer_dom_body.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00032; argG; 1.
DR PANTHER; PTHR11587; ARGININOSUCCINATE SYNTHASE; 1.
DR PANTHER; PTHR11587:SF2; ARGININOSUCCINATE SYNTHASE; 1.
DR Pfam; PF20979; Arginosuc_syn_C; 1.
DR Pfam; PF00764; Arginosuc_synth; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF69864; Argininosuccinate synthetase, C-terminal domain; 1.
DR PROSITE; PS00564; ARGININOSUCCIN_SYN_1; 1.
DR PROSITE; PS00565; ARGININOSUCCIN_SYN_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Arginine biosynthesis {ECO:0000256|ARBA:ARBA00022571};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AGT02467.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000515908}.
FT DOMAIN 5..167
FT /note="Arginosuccinate synthase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00764"
FT DOMAIN 176..394
FT /note="Arginosuccinate synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20979"
SQ SEQUENCE 405 AA; 44673 MW; 542658544CD1BCFA CRC64;
MSKPKVVLAY SGGLDTSVII PWLKENYDYE VIACCADVGQ GGGETDGLQE KAIKSGASKL
YLLNLQEEYV RDFVFPTLKA GAIYEGKYLL GTSHARPVIA KHLVEVAHKE GAVAICHGAT
GKGNDQVRFE LTVMALDPSL KVVAPWREWN IKSREDAIDY AEAHNVPIPC SKSDLYSRDR
NLWHISHEGM DLEDPANEPK YDTLLKLSNA LEKAPDAAEY VTVDFEKGVP VAVNGKKMGP
VELVELLNVI GGKHAVGIED IVEDRLVGMK SRGVYETPAG TILYKALEIL ESLCLDRDTQ
AFKRQSAVRF AELVYDGKWF TPLRESMSAM FDSMAETVTG EVKLKLYKGN VSSAGVKSPY
SLYNENIASF GDSAELYNHK DAEGFIRLFG LPLRVRAMMN QAAKK
//
