ID   S9VR65_9TRYP            Unreviewed;       284 AA.
AC   S9VR65;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Aldo/keto reductase family, putative {ECO:0000313|EMBL:CAD2213493.1};
GN   ORFNames=ADEAN_000093400 {ECO:0000313|EMBL:CAD2213493.1};
OS   Angomonas deanei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Strigomonadinae; Angomonas.
OX   NCBI_TaxID=59799 {ECO:0000313|EMBL:CAD2213493.1, ECO:0000313|Proteomes:UP000515908};
RN   [1] {ECO:0000313|EMBL:CAD2213493.1, ECO:0000313|Proteomes:UP000515908}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Crithidia deanei Carvalho (ATCC PRA-265)
RC   {ECO:0000313|Proteomes:UP000515908};
RA   Newling K., Davey J., Forrester S.;
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LR877146; CAD2213493.1; -; Genomic_DNA.
DR   AlphaFoldDB; S9VR65; -.
DR   EnsemblProtists; EPY26416; EPY26416; AGDE_11346.
DR   EnsemblProtists; EPY43384; EPY43384; AGDE_00537.
DR   VEuPathDB; TriTrypDB:ADEAN_000093400; -.
DR   OrthoDB; 5305445at2759; -.
DR   Proteomes; UP000515908; Chromosome 02.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd19138; AKR_YeaE; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000515908}.
FT   DOMAIN          16..270
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        54
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         113
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            80
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   284 AA;  31390 MW;  B8C5A6A45559E943 CRC64;
     MLKNIVSIGG VSVPAIGQGT WNMGDNKSKR SQELEAIRSG VREGMTVIDT AEMYGSGRSE
     SLVGEAITAL NREDLFLVSK VLPNNAGRRG IFTSCEESLK RLGTTYLDLY LLHWRGGIPL
     RETVECMEEL VAKGKIRRWG VSNFDIDDMK ELWSVPNGDH CAVNQVLYHV GSRGIEYSLL
     PWMKEHHVAA MAYCPLAQAG ELNSNIYTNK TLQKIAADKQ ITMSQLLLAF VVRHGNVMAI
     PKAGNAAHAK ENAKAGDISI SDEEWKEVDK AFPPPNQKEH LDIV
//