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Database: UniProt
Entry: S9VYJ1_9TRYP
LinkDB: S9VYJ1_9TRYP
Original site: S9VYJ1_9TRYP 
ID   S9VYJ1_9TRYP            Unreviewed;       764 AA.
AC   S9VYJ1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   11-NOV-2015, entry version 8.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=AGDE_10301 {ECO:0000313|EMBL:EPY28750.1};
OS   Angomonas deanei.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Strigomonadinae; Angomonas.
OX   NCBI_TaxID=59799 {ECO:0000313|EMBL:EPY28750.1, ECO:0000313|Proteomes:UP000015341};
RN   [1] {ECO:0000313|EMBL:EPY28750.1, ECO:0000313|Proteomes:UP000015341}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23560078;
RA   Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA   Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P.,
RA   Brocchi M., Colabardini A.C., de Araujo Lima B., Machado C.R.,
RA   de Almeida Soares C.M., Probst C.M., de Menezes C.B., Thompson C.E.,
RA   Bartholomeu D.C., Gradia D.F., Pavoni D.P., Grisard E.C.,
RA   Fantinatti-Garboggini F., Marchini F.K., Rodrigues-Luiz G.F.,
RA   Wagner G., Goldman G.H., Fietto J.L., Elias M.C., Goldman M.H.,
RA   Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA   Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA   de Souza W., Schenkman S., de Vasconcelos A.T.;
RT   "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and
RT   Their Respective Endosymbionts Reveals New Aspects of the
RT   Trypanosomatidae Family.";
RL   PLoS ONE 8:E60209-E60209(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EPY28750.1}.
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DR   EMBL; ATMG01010298; EPY28750.1; -; Genomic_DNA.
DR   EnsemblProtists; EPY28750; EPY28750; AGDE_10301.
DR   Proteomes; UP000015341; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015341};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015341};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    330    353       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    374    392       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    491    515       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    557    579       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    702    726       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   764 AA;  86093 MW;  F687692ACA814DD6 CRC64;
     MCASIAEVEE MFLAGQLDLI EEEVRATETD LSAMIQSVEG LQNEVNSNEE IKLLFNRVSQ
     LVYESGEMEP CYDRPFQHLS RISSLLGLID SAQVDVLYRL CYRVTRGNAI ISINNEVEPM
     LNPKTGERDS YKSTFAVLST SPKMIAKLKK LIENMRTTTY TLEEVESRGI QLQRADRMEE
     EEDAVEMRPT DGAVQTLQDL KEAIDGVRRR KESYFLDWYQ KHRTYKVCLA MEKAVLNSMN
     SCTFSGATCT ASVWIAAKYE PALEQALLSA VASSGEVHSV ITRSDPCKNP PTYFETNKFT
     SSFQSIVDSY GMARYKEVNP GVFTIITFPY LFGIMYGDIG HGVLLLLITL YFISKERTWK
     ASQLNEMVAM VFQGRYLLLL MSLFAIYMGF LYNDFFGFSV NIFPSGYTWA SLEDVNLTVT
     QPIIPDGKPS VKPSHVYAFG MDSSWAETEN KLEFYNSVKM KCAVIVGVVQ MFAGIILSLC
     NHIYRRDWFR IAFLTVPEFI FLLCTFGYMS ILIIVKWCTT WTDTSEAPSL LEIMTNFFLQ
     PGNVPKKLFR GQAGLQVFLL IMAFLMVPIM LCGMPIIEYK KYRKHLARMA VLQPSDTFAE
     QATQSEQVII SSSDDGEDVF GDGADIIAEP SAHDDSEEYG ENFDFSEVVI HYLIHTIEYV
     LSSVSNTASY LRLWALSLAH AQLSEVFFTF TIVNVLSADT SGALIALGVL VWLAVTLAVL
     VGMEALSAFL HALRLHWVEF QNKFYAGDGV GLEPFDLTSL DGRM
//
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