ID S9WC16_CAMFR Unreviewed; 3163 AA.
AC S9WC16;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Ryanodine receptor 3 {ECO:0000313|EMBL:EPY73484.1};
GN ORFNames=CB1_004774006 {ECO:0000313|EMBL:EPY73484.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY73484.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY73484.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004326}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB018697; EPY73484.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR Gene3D; 1.10.490.160; -; 3.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF9; RYANODINE RECEPTOR 3; 1.
DR Pfam; PF01365; RYDR_ITPR; 3.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR PROSITE; PS50188; B302_SPRY; 2.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Receptor {ECO:0000313|EMBL:EPY73484.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 124..335
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 551..747
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 2245..2265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2876..2895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2248..2265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3163 AA; 356986 MW; C7D30BA9198A8D1D CRC64;
MLNLFQEEEV LQTLQDLIAY FQPPEEEMQH EDKQNKLRSL KNRQNLFKEE GMLALVLNCI
DRLNIYNSIA HFAGIAREES GMAWKEILNL LYKLLGILEV LHCILIESPE ALNLIAEGHI
KSIISLLDKH GRNHKVLDVL CSLCLCNGVA VRANQNLICD NLLPRRNLLL QTRLINDVTS
IRPNIFLGVA EGSAQYKKWY FELIIDQVDP FLTAEPTHLR VGWASSSGYA PYPGGGEGWG
GNGVGDDLYS YGFDGLHLWS GRIPRAVASV NQHLLRSDDV VSCCLDLGAP SISFRINGQP
VQGMFENFNT DGLFFPVVSF SAGVKVRFLM GGRHGEFKFL PPSGYAPCYE ALLPKEKMRL
EPVKEYKRDA EGVRDLLGTT QFLSQASFIP CPIDTSQVVL PPHLEKVRDK LAENIHELWG
MNKIELGWTF GKIRDDNKRQ HPCLVEFSKL PETEKNYNLQ MSTETLKTLL ALGCHIAHVN
PAAEEDLKKV KLPKNYMMSN GYKPAPLDLS DVKLLPPQEI LVDKLAENAH NVWAKDRLKQ
GWTYGIQQDL KNKRNPRLVP YALLDERTKK SNRDSLREAV RTFVGYGYNI EPSDQELADP
AVEKVSIDKI RFFRVERSYA VRSGKWYFEF EVVTGGDMRV GWARPGCRPD VELGADDQAF
VFEGSRGQRW HQGSGYFGRT WQPGDVVGCM INLDDASMIF TLNGELLITN KGSELAFADY
EIHNGFVPIC SLGLSQIGRM NLGTDASTFK FYTMCGLQEG FEPFAVNMNR DVAMWFSKRL
PTFVNVPKDH PQIEVVRIDG TMDSPPCLKV THKTFGTQNS NATMIYCRLS MPVECHSSFS
HSPCLDSEAF QKRSGKRSLS LVTPNCSLSE GKQQCYYAIR IFAGQDPSCV WVGWVTPDYH
LYSEKFDLSK NCTVTVTLGD ERGRVHESVK RSNCYMVWGG DVVATSQRAS RSNVDLEIGC
LVDLAMGMLS FSANGRELGT CYQNAMPLSA AIFKSEEKNP VPQCPPRLDV QTIQPVLWSR
MPNSFLKVET ERVSERHGWV VQCLEPLQMM ALHIPEENRC VDILELCEQE DLMQFHYHTL
RLYSAVCALG NSRVAYALCS HVDLSQLFYA IDNKYLPGLL RSGFYDLLIS IHLASAKERK
LMMKNEYIIP ITGTTRKIRL YPDASKRHGL PGVGPRTCLK PGFRFSTPCF VVTSEEHQKQ
SPEIPLELLK TKALSMLTEA VQCSGAHIRD PVGGSVEFQF VPVLKLIGTL LVMGVFDDED
VRQILLLIDP SVFGEHSAEM EEGAEKEEVT QVEEKAVEAG EKASKEAGKE APVKGLLQTR
LPESVKLQMC ELLSYLCDCE LQHRVEAIVA FGDIYVSKLQ ANQKFRYNEL MQALNMSAAL
TARKTREFRS PPQEQINMLL NFQLGENCPC PEEIREELYD FHEDLLIHCG VPLEEEEEEE
EDASWTGRFR ALVYKIKGLP KPEKEQPTEE EERSPTTLKE LVSQTMIRWA QEDQIQDAEL
VRMMFTLLRR QYDSIGELLQ ALRKTYTISQ ASVSDTIGLL AALGQIRCLL SVRMGKEEEL
LMINGLGDIM NNKVFYQHPN LMRVLGMHET VMEVMVNVLG TEKSQIAFPK MVASCCRFLC
YFCRISRQNQ KAMFEHLSYL LENSSVGLAS PSMRGSTPLD VAASSVMDNN ELALGLEEPD
LEKVVTYLAG CGLQSCPMLL AKGYPDVGWN PIEGERYLSF LRFAVFVNSE SVEENASVVV
KLLIRRPECF GPALRGEGGN GLLAAMQGAI KISENPALDL PSQVYKREVS TEGDGDEEEI
VHMGNAIMSF YSALIDLLGR CAPEMHKHTC YPCTQEDVHL YMQFGPSHGR GRKGLIIRPQ
LIQTGKGEAI RIRSILRSLV PTEDLVGIIS IPLKLPSLNK DCHRPPSAAV PMYLMAMGHN
KLSLDGSIYE PDMAANFCPD HKAPMVLFLD RVYGIKDQAF LLHLLEVGFL PDLRASASLD
TVALSTTEAA LALNRYLCAA VLPLLTRCAP LFAGTEHYTS LIDSTLQTIY RLSKGRSLTK
AQRDTIEQCL LAICNITRIS QIYRQRSQKK FSASPDWLEQ HLLLTNHYEQ CWKYYCLPSG
WGSYGLAVEE ELHLTEKLFW GIFDSLSHKR YDSDLFRMAL PCLSAIAGAL PPDYLDTRMS
ATLEKQVSVD ADGNFDPKPI NTVNFSLPEK LEYIVTKYAE HSHDKWACDK EKEIYRWPAR
ESLKTMLAVG WTVERTKEGE ALVQQRENEK LRSVSQASQG NSYSPTPLDL SNVVLSRELQ
GMVEVVAENY HNIWAKKKKL ELESKGGGSH PLLVPYDTLT AKEKFRDREK AQDLFKFLQV
NGVVVSRGMK DMELDASSME KRFAYKFLKK ILKYVDSAQE FIAHLEAIVS SGKTEKPPHD
QEIKFFAKTH LYHTCEKGEG KEREGPLVAG IKGKKVLEAE IHRVLLPLVD QYFTNHRLYF
LSSPLKPLSS SGYASHKEKE MVARTVVKSG SELAKAGLRA FFENAAEDLE KTSENLKLGK
FTHSRTQIKG VSQNINYTTV ALLPILTSIF EHVAQHQFGV DLLLGDVQIS CYHILCSLYS
LGTGKNIYVE RQRPALGECL ASLAAAIPVA FLEPTLNRYN PLSVFNTKTP RERAILGMPD
TVEEMCPDIP QLEGLMKEIN DLAESGARYT EMPHVIEVIL PMLCNYLSYW WERGPEHLPP
STGPWCTKVT SEHLSVVLGN ILKIINNNLG IDEASWMKRI AVFAQPIISK ARPDLLRSHF
IPTLEKLKKK ALKTVQEEEQ LKADSKGDTQ EAELLILDEF AILCRDLYAF YPMLIRYVDN
NRSNWLKSPD ADSDQLFRMV AEVFILWCKS HNFKREEQNF VIQNEINNLA FLTGDSKSKM
SKSGGQDQER KKTKRRGDLY SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYSYS
DDPAVKWQLN LYKDVLKSEE PSNPEKTVER VQRISAAVFH LEQVEQPLRS KKAVWHKLLS
KQRKRAVVAC FRMAPLYNLP RQVVCHFSPG VHRSINLFLH GYQRFWIETE EYSFEEKLVQ
DLAKSPKLEE EEEEETEKQP DPLHQIILHF SRNALTERRS APQGTLLIPG TGAAVSTPDG
PPAGGCVRRG DARFEQPFWP ALLLAIKEPL EELDKPRPFH HNA
//
