ID S9WLR0_CAMFR Unreviewed; 2269 AA.
AC S9WLR0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Striated muscle preferentially expressed protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CB1_000931066 {ECO:0000313|EMBL:EPY79427.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY79427.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY79427.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR EMBL; KB017173; EPY79427.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd20975; IgI_APEG-1_like; 1.
DR CDD; cd14108; STKc_SPEG_rpt1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47633:SF7; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF07679; I-set; 8.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF16650; SPEG_u2; 1.
DR SMART; SM01391; Filament; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 8.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 8.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS50835; IG_LIKE; 7.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..234
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 450..538
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 626..715
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 720..814
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 821..909
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 945..1035
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1042..1139
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1263..1351
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1379..1645
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1745..1835
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1842..1935
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1943..2207
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 296..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 33..85
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 118..212
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 324..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1408
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2269 AA; 251876 MW; BEF7764463077163 CRC64;
MDKLEGSGER VEELWPSESL ENKMVDSTML PDVDAATLAR IDLERRIESL NEEIAFLKKV
HEEEIRELQA QLQEQQVQVE MDMSKPDLTA ALRDIRAQYE TIAAKNISEA EEWYKSKVSD
LTQAANKNND ALRQAKQEMM EYRHQIQSYT CEIDALKGTN DSLMRQMREL EDRFASEASG
YQDNIARLEE EIRHLKDEMA RHLREYQDLL NVKMALDVEI ATYRKLLEGE ESRINLPIQT
FSALNFRGIR AGLNAFRKPC PPRTRASFLP SRGYGPLGDF AFRPLITLAA LLTPIPNSET
GEDDISDVQG TQRLELRDDG AFSTPTGGSD TLVGTSLDTP PTSVTGTSEE QAVRFLPWAT
PGQEGAAVPQ TLEKNRVGPE AEKRLRRGPE EDGPWGAWDR RGARSQGRGR RARPTSPELG
TTSLTLSPVS PTESSDDSYV SAGEEPLEAP VFEIPLQNAV VAPGVDVLLK CIVTANPPPQ
VSWQKDGSSL RSDGRLLIRA EGERHTLLLR EARAADAGSY TATATNELGQ ASCAATLAVK
PGRDPVGPRA GSFQLHLPDF ADLQVVIFSL RGSTSPFSSP ITSDEEYLSP PEEFPEPGET
WPRAPTMKLS PGQNRRSSDT GSKAPPTFKV SLMDQSVREG QDVTMSIRVQ GEPKPVVSWL
RNRQPVRPDQ RRFAEEAEGG LCRLRILAAE RGDAGFYTCK AVNEYGARQC EARLEVRAHP
ESRSLAVLAP LQDVDVGAGE MALFECLVAG PADVEVDWLC RGRLLQPALL KCKMHFDGRK
CKLLLTSVHE DDSGVYTCKL STAKDELTCS ARLTVRPSLA PLFTRLLEDM EVLEGRAARF
DCKISGTPPP SVTWTHFGRP VEESENLRLR QDGGLHSLHI AHVGSEDEGL YEVSATNSHG
QAHCSAQLYV EEPRMAATGP SSKLEKMPSI PEEPEQGELE RLSMPDFLRP LQDLDVGLAK
EAMLECQVTG LPYPTITWFH NGHRIQSSDD RRMTQYRDVH RLVFPAVGPQ HAGVYKSVIA
NKLGKAACYA HLYVTDVVPG PPDGAPQVVA VTGRMIKLMW NPPRSLDMAI DPDALTYTVQ
HQVLGSDQWT ALASGLREPG WAAMGLRKGI QHSFRVLSTT IKSSSKPSPP SEPVQLLEHG
GVPVGWGWGW GQELLGQGAR CPPLEEAPAV LDKPDIVYVV EGQPASVTVT FNHVEAQVVW
RSCRGALLEA RAGVYELSQP DDDQYCLRIC RVSRRDMGTL TCTARNRHGT QACSVTLELA
EAPRFESIME DVEVGAGETA RFAVVVEGKP LPDIMWYKDE VLLTESNHVS FVYEENECSL
VVLSAGDQDG GVYTCTARNL AGEVSCKAEL AVHSAQTAME VEGVGEDEEQ RGRRLSDFYD
IHQEIGRGAF SYLRRVVERS SGLEFAAKFI PSQAKPKASA WREARLLARL QHDCVLYFHE
AFERRRGLVI VTELCTEELL ERMARKATVC ESEIRAYMRQ VLDGICYLHE NHVLHLDVKP
ENLLVWDGVE GEEQVKICDF GNAQELTPGE PQYCQYGTPE FVAPEIVNQT PVLGLPACSH
LASPSEADIA FWPVGVVAFL CLTGISPFVG ENDRTTLMNI RNYNVAFEET TFLSLSREAR
GFLIKVLVQD RLRPTAEETL EHPWFKRSQI SYKCHLVLRP IPELLRAPPE RVWVAVPRRP
PPSGGLSSSS DSEEEELEEL PSVPRPLQPE FSGSRVLRKD KGLSQPNLSA SVQEDLGHQY
VRNFPPVFHI KLKDQVLLEG EAATLLCLPA ACPAPHISWM KDKQSLRSEP SVIIVSCKDG
RQLLSIPRAS KRHAGLYECS ATNVLGSITS SCTISVARVP GKLAPPEVPQ TYQDTALVLW
KPGDSRAPCT YTLERRVDGE SSWHPVSSGI PDCYYNVAHL PVGMTVRFRV ACANRAGQGP
FSNPSEKVLV RGMPDVCSSD LPLSPLLSPP RGRFGVVRAC RENATGRTFM AKIVPYAAEG
KRRVLQEYEV LRTLHHERLM SLHEAYITPR YLVLIAESCG NRELLCGLSD RFRYSEDDVA
TYVVQLLQGL DYLHGRHVLH LDIKPDNLLL APDNALKIVD FGSAQPYNPQ ALRPLGHRTG
TLEFMGSWFN LASCLLSAPE MVKGDPIGSA TDIWGVGVLT YIMLSGRSPF YETDPQETEA
RIVGGRFDAF QLYPNTSQSA TLFLRKVLSV HPWSRPSLQD CLAHPWLQDA YLMKLRRQTL
TFTTNRLKEF LGEQRRRRAX XXXXXXXXXR RAEAATRHKV LLRSYPGNP
//
