ID S9WWB6_CAMFR Unreviewed; 1114 AA.
AC S9WWB6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 03-MAY-2023, entry version 32.
DE SubName: Full=RUN and TBC1 domain containing 2-like protein {ECO:0000313|EMBL:EPY80363.1};
GN ORFNames=CB1_000841028 {ECO:0000313|EMBL:EPY80363.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY80363.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY80363.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the RUTBC family.
CC {ECO:0000256|ARBA:ARBA00034124}.
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DR EMBL; KB017092; EPY80363.1; -; Genomic_DNA.
DR AlphaFoldDB; S9WWB6; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd15784; PH_RUTBC; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.230; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037745; SGSM1/2.
DR InterPro; IPR021935; SGSM1/2_RBD.
DR PANTHER; PTHR22957:SF187; SMALL G PROTEIN SIGNALING MODULATOR 1; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12068; PH_RBD; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 40..210
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 582..1047
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 397..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 125769 MW; 6E77AF259A8A2064 CRC64;
MDVLAWLSLR GLQSSQKWHT GPSMGVKQIM EEAVTRKFVH EDSSHIISFC AAVEACVLHG
LRRRAAGFLR SNKIAALFMK VGKSFPPAEE LSRKVQDLEQ LIESAPCQPR GLGQICMMGQ
ALDWIQGLQE NVRKLPKLPS LSPLAIKHLW IRTALFEKVL DKIVHYLVEN SSKYYEKEAL
LMDPVDGPIL ASLLVGPCAL EYTKMKTSDH FWTDPSADEL VQRHRIHSSH LRQDSPTKRP
ALCIQKRHSS GSMDDRPSLS ARDYVESLHQ NSRATLLYGK NNVLVQPRDD MEAVPGYLSL
HQTADVMTLK WTPNQLMNGS MGDLDYEKSV YWDYAMTIRL EEIVYLHCHQ QVDSGGTVVL
VSQDGIQRPP FRFPKGGHLL QFLSCLENGL LPHGQLDPPL WSQRGKGKVF PKLRKRSPQG
SSESTSSDKE DDEATDYVFR IIYPGMQSEF VPQDLMDVSV SNLPSLWQPS PRKSSCSSCS
QSGSADGGSA NGCNHERAPL KLLCDNMKYQ ILSRAFYGWL AYCRHLSTVR THLSALVNHM
IVSPNLPCDA GHGLTARIWE QYLQDSTSYE EQELLRLIYY GGIQPEIRKA VWPFLLGHYQ
FGMTETERKE VDEQIHACYA QTMSEWLGCE AIVRQRERES HAAALAKCSS GASLDSHLHR
LMHRDSTISN ESSQSCSSGR QNIRLQSDSS SSTQVFESVD EVEQVEAEGR LEEKQPKIPN
GNLVNGTCSP DSGHPSSHNF SSGLSEHSEP SLSTEDSVMD AQRHAPLVLR PRGSSVDDGQ
SSEATTSRDE VPREELAVQD SLKSDLLANE SVGEFMSITG SMDMALLKKE GTGMEGWRGS
EAEKHSQVDS EDNLSEEPEM ESLFPALASL AVTTSANNEA SPVSSSGVTY SPELLDLYTV
NLHRIEKDVQ RCDRNYWYFT PANLEKLRNV MCSYIWQHIE IGYVQGMCDL LAPLLVILDD
EALAFSCFTE LMKRMNQNFP HGGAMDTHFA NMRSLIQILD SELFELMHQN GDYTHFYFCY
RWFLLDFKRE LLYDDVFSVW ETIWAARHVS SAHYVLFIAL ALVEVYRDII LENNMDFTDI
IKFFNEMAER HNTTQVLKLA RDLVHKVQTL IENK
//
