ID S9X480_CAMFR Unreviewed; 3713 AA.
AC S9X480;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 08-NOV-2023, entry version 40.
DE SubName: Full=Dynein heavy chain 11, axonemal {ECO:0000313|EMBL:EPY83258.1};
GN ORFNames=CB1_000577004 {ECO:0000313|EMBL:EPY83258.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY83258.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY83258.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KB016854; EPY83258.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 2.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 2.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 1295..1392
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1784..1929
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2075..2187
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 480..507
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2553..2580
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3713 AA; 425874 MW; B84A765BDAC91D5B CRC64;
MVKILKNKQS SYFPTVKDIF MAVKHALLEA RDVELHLRPL RRHIQCLQET EFPQIRVLIA
PLFHTICLIW SHSKFYNTPA RVIVLLQEFC NLFIDQAVAY LSPEELLKGE IEDSLEKVQV
AVNILKTFRN SFFNYRKGLA SYFVGSKELK PWDFQSHLVF CRFDKFLDRV MKIEDIFVTM
LEFEKLDRLE FGGTKGAILN GQIHEMSEEF MELCKLFKQS AYDACDDNNM EFESDYVIFK
SKTLDFDRRL GTILCEAFVN CNGLEATFKL LTVFGNFLEK PVVMEIFSPH YSTLVHMLSA
ELDVCKQLYN EHMKQIEQGN VVLNKNMPFT SGNIKWAEEV LDRLHMFWSN FASLRYLFLE
SPDDALVYQK YVEMTTLLDQ FENCIYNEWK SNVDEICEFN LNQPLVKFSA VNGLLSVNFD
PKYIGNLELL VQGYNKLKQT LLEVEYPLIE DELRAVDEEL WAAAAAATSL TWQDDCWGDI
ERVKVSTSEL ERRVERAQSN VKVIQQMMRA WAECTLLPRR EHRRETAFTW EDKGDLFAKK
YKLIQDDGCK IHNLVEENRK LFKADPSLDT WKIYVEFIDD IVVEGFFQAI MHDLDFFLMN
TEKRLKPAPF FQAQMILMPP EILFKPSLER EAGDGFYDLV EEMLCNSFRM SAQMKRVAAH
LEMANYQNDM DNMLGLTAGR QEIMKRVADV INKVLDFRNT LDAYAYLWVD DRAEFLKHFL
LYGHTASSED GDLHADEDGP EQPPTLEQFK EQARKTFSID IYEALYVQMS KFDDFRVFDS
WFKVDMKPFK VTLLNMIRKW SWMFQEHLLR FVIDSLNELQ EFIKETDAGL QRELREGDHD
GLVDIMGHLL AVRSRQRATD ELFEPLKETI TLLESYGRKM PEQVYMQLEE KQADFTERFR
LYAPLGFNAE SPYTVLDKAN QELEALEEEM FQMQESTHLF EVAPPDCKQM KQCRKEMKLL
KGLWDVIIYV REIWSLDKEV RVWEAYSGLE GTVKDAVTAL RAIAELQSPA LRDRHWHQLM
KAVGVKFSIN EATTLADLLA LQLHQVEDHV RSIVDKAVKE LGTEKVITEI TQTWATMEFS
YEVHYRTGIP LLKSDEQLFE TLEHNQVMHH LSKLFDSIAD LQFEDGRDVS THRAVGMYSK
EKEFVPFQAE CACIGHLEQT MQETVRCSII EAIAAYEDKP RELWIFDFPA QVALTSSQIW
WTTDVGIAFS RLEEGYETAL KDFHKKQVIS PQAFAWLSQL RHQWEDTQKH CLVNICDAQF
QYFYEYLGNS PRLVITPLTD RCYITLTQSL HLTMSGAPAG PAGTGKTETT KDLGRALGMM
VYVFNCSEQM DYKSIGNIYK GLVQTGAWGC FDEFNRISVE VLSVVAVQVK MIHDAIRNRK
TRPCAMVAPD IELICEIMLV AEGFVDARLL AHKFITLYTL CRELLSKQVL MRALRDFNMP
KIVTDDIPVF LGLIGDLFPA LDVPRRRAPH FEEVVRQSTV ELHLQPEEAF ILKVVQLEEL
LAVRHSVFVV GNAGTGKSLF SSILREQANL THDGPKWIVL DGDIDPMWIE SLNTVMDDNK
VLTLASSERV ALTPSMRLLF EVHHLRTATP ATVSRAGILY VNPQDLGWNP YVASWIDRRQ
HQSEKANLTI LFDKYVPVCL DKLRTSFKTI TSIPENSLVQ TICTLLECLL TPENVPSDSP
KEVYEVYFVF ACIWAFGGTL LQDQLSGYQA EFSWWWHKEM KAVKFPSQGT IFDYYLDHKT
KKFMPWADKI PQFMMDSDAP LQRVVVHTSE TTRLRYFIEL LLEKGQPLML VGNAGVGKTV
FVGDMLASLS EDYIVSRVPF NYYTTSAALQ GVLEKPLEKK AGRNYGPGGN KKLIYFIDDM
NMPAVDLYGT VQPHTLIRQH IDYGHWYDRQ KVMLKEIHSC QYIACMNPKV GSFTINPRLQ
RHFTVFAFNF PSLDALNTIY SQILSFHFQQ QAFASSVLRS GPTLIQATIA FHQMMTRNFL
PTAIKFHYLF NLRDLSNIFQ GVDSRVLLQQ PLIYCHFANG REDPCYMPVK DWEVLKTFLT
ETLENYNELN AAMHLVLFED AMQHVCRISR LLRTPQGHAL LIGVGGSGKQ SLSRLAAYIC
SLEVFQITLT EGFGVQEFQV DLANLYIRAG AKNMPTVFLL TDAQVLDESF LVLINDLLAS
GEIPDLFSDE DVDKIISGIR NEVRGLGMMD SRENCWKFFL SRVQLQLKII LCFSPVGHRL
RARACKFPAL VNCTAVDWFH AWPREALVTV SRRFIDEAKG IECLCLQPLN KDAVSLFMAH
VHTSVSEMST RYYQNERRYN YTTPKSFLEQ VSLFKSLLKK KQKEVSRKKE HLVNGIQKLK
TTASQVGDLK GRLASQEAEL QLRNHDAEAL ITKIRLQTEK VSREKAIADA EEQKVTAIQT
EVSQKQRECE ADLLKAEPAL VAATAALNTL NRVNLTELKV FPNPPNAVTN VTAAVMVLLA
PRGRVPKDRS WKAAKVFMGK VDDFLQALIN YDKEHIPENC LKVVNEQYLK DPEFNPNLIR
TKSFAAAGLC AWVINIIKFY EVYCDVEPKR QALAQANLEL AAATEKLESI RKKLASEKIR
WGQAIKSFEA QEKTLCGDVL LTAAFVSYVG CFTRQYRQEL VDCMWVPFLR QKVYIPITEG
LDVMTMLTDD ATVAAWNNKG LPSDRMSTEN AAILTHCERW PLMIDPQQQG IKWIKNKYGT
ALRVTRLGQK GFLNDIETAL AFGDVVLIEN LEETIDPVLE PLLGRNTIKK GKYIKIGDKE
CEFNQNFHLI LHTKLANPHY KPELQAQTTL LNFTVTEDGL EAQLLAEVVS IERPDLEKLK
LVLTKHQNDF KIELKHLEDD LLLRLSAAEG SFLDDTKLVE RLEATKVTAA EIEHKVTEAK
ENERKINAAR ECYRPVAARA SLLYFVINDL RKINPIYQFS LEVTSIPQAF NMLFHRAMEQ
ADKVDDTQGR ISVLMESITH AVFLHTSQAL FEKDKLTFLS QMAFQILLKR KEIDPLELDF
LLRFTVEHTY PSPVDFLTTQ SWSAIKAVAL MEEFRGIDRD VEGSAKLWRK WAESECPEKE
KLPQEWKKKS LIQKLIILRA MRPDRMTYAL RNFVEEKLGA KYVERTRLDL AKAFEESSPA
TPVFFILSPG VDALKDLEVL GKRLGFTSDS GKFHNVSLGQ GQEMVAEMAL EKASKGGHWV
ILQNVHLVAK WLGTLEKLLE RFSQGSHRDY RVFMSAESAP TPDEHVIPQG LLENAIKMTN
EPPTGMLANL HAALCSFDQD TLEVCSKEQE FKSILFSLCY FHACVAGRLR FGPQGWSRSY
PFSPGDLTIC ASILYNYLEA SPHVPWEALR YLFGEIMYGG HITDDWDRKL CRAYLEEFMN
PSLIEDELML APGFAAPPNL DYSGYHQYIE EMLPPESPAL YGLHPNAEIE FLTVTSNALF
RTLLEMQPRN ALSSEELGQS IEDKVKNVLD DILEKLPEEF NMAEVMQKNP NRGPYVLVCF
QECERMNILL REIRVSLQQL DLGLKLQKAE VPFAVAEGTT TSSSSVTAQA SHPGLPCPES
PLHFARGLND LLLRCRELDT WTQDLALPAV VWLSGFFNPQ SFLTAIMQTM ARKNEWPLDK
ICLTVDVTKK TKEDYGHPPR EGAYLHGLFM EGARWDPQSG TIADARLKEI RSAMPVIFAK
AIPVDRQETK HTYECPVYKT KTRGPDYVWT FRLKSKEKTA RWMLAGVALL LES
//
