ID S9X615_CAMFR Unreviewed; 1441 AA.
AC S9X615;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
DE Flags: Fragment;
GN ORFNames=CB1_000331014 {ECO:0000313|EMBL:EPY86047.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY86047.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY86047.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; KB016621; EPY86047.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR CDD; cd13244; PH_PLEKHG5_G6; 1.
DR CDD; cd17068; RBD_PLEKHG5; 1.
DR CDD; cd13420; TNFRSF25; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040181; PKHG5/7.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR034050; TNFRSF25_N.
DR PANTHER; PTHR13217:SF11; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5; 1.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00208; TNFR; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 1359..1402
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 1359..1402
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 550..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1173
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1441
FT /evidence="ECO:0000313|EMBL:EPY86047.1"
SQ SEQUENCE 1441 AA; 158298 MW; 8F8BB01A8BEB3C78 CRC64;
MHANGGGICR VTCLYGQVQV LGFAISQGQP AQDVFSTYTH SRLTISAVHY SVPEKSKEMK
REARALLRSH LSRGPPFTHQ RTPQKMVYYG KPSCKNNFEN YIEIIKYVFS SYRRESPLIV
NTMGWVADQG LLLLIDLIRL LSPSHVIQFS SDRSKYMPDL TPDYVDDMDG LYTRSKSKVR
NRGFYLPEFA DNSEFADEEK DSPVVFTGYK LMSVKSEFVS RKTPRNRESH NRVLRDLAVL
SYLGQLQPPV PKPLCPLHGL TPYQVPFNAV ALRIIHADVA PTHILYAVNA SWVGLCKILD
DVRGYANGPI LLAQTPICDC LGFGICRGID MERRLYHILT PVPPEELRNV NCLLVGAISV
PQCVFKSQIY LNTSLPAAGP VQKPQRDCGL GFSNTLELGR SLGCEGLLGR EKPPNLQAFL
LTRVQPELLL AAGIAETRGF VALLSGKGEG QAPAKAASSV RSVFQGAYGY LGMENPRGEN
HRQGNSANHG HGVHTLKYTA LGGPVPEEKR IGRAESLVVF CADDSAGEIT TEAGSGRSPP
VLGLQLGREG RGRGLARGSR ARHSATTPEV KHELSPDKVR VSTSQLARPS SGSRKRGAYE
LEALPGALAE LELGAVERFS WSSTLDIIED LREDRSLVEE KGLRCQNPDC MDKGRAAKLL
LGQAHELLQE VGRGEADEMR ADVRVCHHAD CQQLHRRGPL NLCEACDSKF HSAMHYDGHV
RFDLPPQGSV LARNVSTRSC PPRTSPAADL EEEEEGSVDG KGDRKSTGLK LSKKKARRRH
TDDPSKECFT LKFDLNVDIE TEIVPAMKKK SLGHPAHVVC TLVRVLECVN LCGQVCVCMH
LEVLLPVFER KGIALGKVEI YLDQSNTPLS LTFEAYRFGG HYLRVKGEQA PGRRRKNMSE
FLGEASIPGQ EPLTPSSCSL PSSSSGGGDS WKNRAASRFS GFFSSGPSTS AFGREVDKME
QLEGKLHAYG LFGLPRLPRR LRFDHDSWEE EGDEEEDEDD ACLRLEDSWR ELIDGHEKLT
RRQCHQQEAV WELLHTEASY IKKLRVITNM DVYCFLFTDL LLVTKAVKKA ERTKVIRPPL
LVDKIVCREL RDPGSFLLIY LNEFHSAVGA YTFQASGQAL CRGWVDAIYN AQNQLQQLRA
QEHPGGQQQL QSLEEEEDEQ EEEEDEDEEE GGESSTSAAS SPTILRKSSS SPDSQHCASD
GSTETLAMVV VEPGEMLSSP EFEGGPFSSQ SDETSLSTTA SSVTPTSDLL PLGPVDGRSC
SMDSAYGTLS PTSLQDFVAP APLLLPCLPH LLKSKSEASL LQLLTQGSSQ EAGPSWDYQG
TPGLGSGSRL SELYGGASCP GHYLKAPCTE ACGAATCLPC PQGTFLAWEN HHETRCARCQ
ACDEQAPQVA LKNCSAVADT HCGCKPGWFT ECVVSRCLHG SPFRCRPCTD CGALHRHVRV
P
//
