ID S9X9F0_CAMFR Unreviewed; 2038 AA.
AC S9X9F0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Cadherin EGF LAG seven-pass G-type receptor 1-like protein {ECO:0000313|EMBL:EPY87027.1};
GN ORFNames=CB1_000279025 {ECO:0000313|EMBL:EPY87027.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY87027.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY87027.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Receptor that may have an important role in cell/cell
CC signaling during nervous system formation.
CC {ECO:0000256|ARBA:ARBA00002066}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7
CC subfamily. {ECO:0000256|ARBA:ARBA00010933}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KB016572; EPY87027.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00055; EGF_Lam; 1.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF470; LATROPHILIN-LIKE PROTEIN LAT-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00053; Laminin_EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00180; EGF_Lam; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EPY87027.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1484..1507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1519..1536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1542..1565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1586..1606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1626..1646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1667..1689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1695..1718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 210..246
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 411..449
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 450..677
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 680..716
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 720..901
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 903..939
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 940..977
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1034..1081
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1066..1139
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 1482..1719
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1280..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..2009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1806..1824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1841..1858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1974..1989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 198..207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 706..715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 929..938
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 967..976
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1034..1046
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1036..1053
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1055..1064
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 2038 AA; 222575 MW; FE588842E34479F5 CRC64;
MSAAGLATPS SRVRTAALTS AAPCDGQLDG IHSVVALCTL RVTIITDDML TNSITVRLEN
MSQEQFLSPL LSLFVEGVAT VLSTTKDAVF IFNIQNDTDV SSNILNVTFS ALLPGGVQDK
FFPSEDLQEQ IYLNRTLLTA VTAQRVLPFD DNICLREPCE NYMKCVSVLK FDSSAPFISS
PTVLFRPIHP VNGLRCRCPP GFTGDYCETE IDLCYSSPCG ANGRCRSREG GYTCECQEDF
TAVTRGTPVT LIRPQPVESR YFLRLCWGLF WAERSPPSSP RLQGQPARGE QVAGLAGPSG
LCLWVLPGGG VEHREPTRAC LALGVGSRWV MGLVPRMGMN FNRRGTRGCP EEGLGSGAVA
AGSRLPQASA LEMPRREGCA GRRARSLHLH TDPSPAVGCP SKGEHCEVNV RSGRCAHGVC
KNGGTCVNLL IGGFHCVCPP GEFERPYCEV TTRSFPPQSF VTFRGLRQRF HFTVALAFAT
QERNALLLYN GRFNEKHDFI ALEIVDEQVQ LTFSAGETTT TVSPQVPGGV SDGRWHSVQV
QYYNKIPVGL SHLTQLLWRT EVPLGLPQPH IGRLGLPHGP SGEKVAVVTV DDCDTAVAVR
FGSFVGNYSC AAQGTQSGSK KSLDLTGPLL LGGVPNLPED FPVHNRQFVG CMRNLSIDGR
KVDMASFIAN NGTRAGCTAQ RNFCEGSWCQ NGGTCVSGWN TYVCECPLRF GGKNCEQVMP
HPQRFSGESV VSWSDLDVTV SVPWYLGLMF RTRKEDGVLL EATAGVSSRL HLQILNNYVQ
FEVSHGPSDV VSMRLSRSRV TDGAWHHLLV ELKSAKEGKD IKYLAVMTLD YGMDQETVQI
GNQLPGLRMR SIIVGGVSED KVSVHRGFRG CMKGVRMGET ATNIATLNMN DALKVRVQDG
CDVEDPCSSS PCPQHSRCHN TWDGYSCVCD RGYFGRKCVD ACHVNPCKHV AACVHSPESP
RGYVCECGSG HYGQYCENKI DLPCPKGWWG NPVCGPCHCA VNKGFDPDCN KTSGQCQCKE
NYYRPPEQDA CLPCDCFPHG SHSRACDMDS GQCTCKPGVV GRQCNRCDNP FAEVTVLGCE
VIYNGCPRAF EAGIWWPQTK FGQPAAVPCP KGSVGNAVRH CSGEKGWLPP ELFNCTTASF
VDLKALNEKL SRNETRMDSD RSLRLAQALR NATQQPDTLF GSDVRTAYQL LAHVLLHESG
QQGFELAATR DATFHEDVIR AGSALLAPST RAAWEQIQRS EGGTARLLRR FEAYLSNVAR
NLRKTYLRPF VIVTSNMKGP TVRPAGRKAT PQTTRPRPSA QTEAPFRRRK RHPDEPGQFA
VALVIVYRTL GQLLPEHYDP DRRSLSDRTF TKLDDAPAAP SRTFSRGRRS ELVSFIRLPN
RPVINTPVVS TVVYSEGAPP PSPLQRPVLV EHTLLETEER TKPVCVFWNH SITLGGTGGW
SAKGCELLSR NRTHVTCQCS HATSSAVLMD VSRREHGEVL PLKIVTYAAV ALSLAALLVA
FVLLALVRRL RSNLHGIHKN LIVALFFSQL VFVIGIDQTE NPFLCTVIAI LLHYVYMSTF
AWTFVESLHV YRMLTEVRNI DAGPMRFYYV VGWGIPAIVT GLAVGLDPQG YGNPDFCWLS
LHDTLIWSFA GPIGTVIIVN TVIFVLSAKV SCQRKRHYYE RKRVVSLLRT AFLLLLLIGA
TWLLGLLAVN SDVLTFHYLF AIFSCLQGLA VLLLHCVLSR EVRKHLKGVL AGKKSYLDDS
ATTRATLLTR SLNCNNTYGE EPAMFRTALG ESTASLDSTV RDEGGQKLSV SSGPARGGHG
EPDSAFVPRS SKKPHGHDSD SDSELSLDEQ SSSYASSHSS DSEDDGVEAE DKWDPARGPV
HSTPKVDAAA NHIPAGWPEE TLAGSDSEEP GEQPCLKVET KVSVELHLDP QGNHCSERVP
ERESGGPPKA TGAPPSQPPE QRKGILKNKV TYPPPLTEKT LKSRLREKLA ECEQSPASSR
SSSLGSSDGI RAPDGTITIK TPCREPGREH LNGVAMNVRA GSAQARGSGS EVGIYVLL
//
