ID S9XN10_CAMFR Unreviewed; 1367 AA.
AC S9XN10;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Mismatch repair endonuclease PMS2 {ECO:0000313|EMBL:EPY89044.1};
GN ORFNames=CB1_000138013 {ECO:0000313|EMBL:EPY89044.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY89044.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY89044.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KB016435; EPY89044.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF02493; MORN; 7.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00698; MORN; 8.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Endonuclease {ECO:0000313|EMBL:EPY89044.1};
KW Hydrolase {ECO:0000313|EMBL:EPY89044.1};
KW Nuclease {ECO:0000313|EMBL:EPY89044.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 227..364
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 683..827
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 393..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 152701 MW; 19718E26C0A8A7E0 CRC64;
MDRAEGPSSE CAKAIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSVDAG ATNIDLRLKD
YGVDLIEVSD NGCGVEEENF KGLTLKHHTS KIQKFADLTQ VETFGFRGEA LSSLCALSDL
AISTCHTSAN VGTRLVFDHN GKILQKTPYP RPRGTTVSVQ QLFYTLPVRH KEFQRNIKKE
FAKMVQVLHA YCIISAGVRV SCTNQVGQGK RQLVVSTSGS SSIKENIGSV FGQKQLQSLM
PFVQLPPSDS VCEEYGLSCS DALHNLFQLS GFISHGTHGV GRSSTDRQFF FINRRPCDPA
KVSRLVNEVY HMYNRHQYPF VVLNISVDSE CVDVNVTPDK RQILLQEEKL LLAVLKTSLI
GMFDSDVNKL SISQQPLLVA EGNLIKMHSA ETEKPRLEKP AHPTLLGTPG EEKKAVTISR
LREAFSLRHP SGPKSGGPMT ADPRCISPRQ KRSTLFSSAP GSLCSGKAIS GPREEGMGSA
RGPCDPMDTV KMEEDSGHSS ASAGSEEGFS TPETVGHPSS DPMTSSPEDG LSQENVESGG
NLPETDQPCP GPESPSVQEE RGYRVLPQCT NLAAPNIKRF KKEGIPLNPD VPPESLRTPD
TSGSEVDSEV DVAVKIQKKI VPLDFSMHSL VKRMKQLWQQ DWQQEGGQSY RKFRAKICPG
ENQAAEDELR KEISKTMFAE MEIIGQFNLG FIITKLNADI FIVDQHATDE KYNFEMLQQH
TVLQGQRLIA PQSLNLTAVN ESVLLENLEI FRKNGFDFVI DEDAPVTERA KLISLPTSKN
WTFGPQDIDE LIFMLSDSPG IMCRPSRVRQ MFASRACRKS VMIGTALNTS EMKKLITHMG
TFSRVSASAL NVFREGGTCS CPDTRGTQSS YEGGKVHGRY EGEGFAVFQG GGTYHGDFVK
NLPMNHGIYT WLDGSTYEGE VLNSMRNGFG TFKCGTQPVS YIGHQCHGKR HGKGSIYYNQ
DGTSWYEGDW VYNIKQGWGI RCYKSGNIYE GQWENNVRHG EGRMRWLITN EEYTGQWDRG
VQNGFGTHTW FLKRIPYSQY PLRNEYIGEF VKGARHGHGK FYYASGAMYE GEWVSNKKHG
MGRLTFKNGR VYDGPFCNDH IAEFPDLEGE LISYPDLPSE PALRSQSLGS SISTEIIRKL
DGSESSSVLG LSIELDLSLV LNMFPERDQS EEKKQVEYAI LRNITELRRI YSFYSSLGCS
CSLDNTFLMT KLHFWRFLKD CKFHHHKITL ADMDRVLSGH LFCEVQRTLY SMNYIDKCWE
IYTVYCRPSA APPYELTMKM RHFLWMLKNF KMINKELTAT KFVEVIAEDN PFVHDGIDSN
FELELGNVFL GHDPGSRLLA TMVEICAFPN AGGGGGVHWL DHKAHSI
//
