ID S9XPC9_CAMFR Unreviewed; 759 AA.
AC S9XPC9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Multifunctional fusion protein {ECO:0000256|RuleBase:RU367118, ECO:0000256|RuleBase:RU369067};
DE Includes:
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
DE Includes:
DE RecName: Full=WD repeat-containing protein 18 {ECO:0000256|RuleBase:RU369067};
GN ORFNames=CB1_000097002 {ECO:0000313|EMBL:EPY89529.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY89529.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY89529.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC transactivation of ZNF148 target genes. Component of the PELP1 complex
CC involved in the nucleolar steps of 28S rRNA maturation and the
CC subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May
CC play a role during development. {ECO:0000256|RuleBase:RU369067}.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBUNIT: Component of the 5FMC complex, at least composed of PELP1,
CC LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated
CC CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex,
CC composed of at least PELP1, TEX10 and WDR18. The complex interacts with
CC pre-60S ribosome particles. {ECO:0000256|RuleBase:RU369067}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU369067}. Nucleus, nucleoplasm
CC {ECO:0000256|RuleBase:RU369067}. Cytoplasm
CC {ECO:0000256|RuleBase:RU369067}. Dynein axonemal particle
CC {ECO:0000256|RuleBase:RU369067}. Note=Mainly found in the nucleoplasm,
CC with low levels detected in the cytoplasmic and chromatin fractions.
CC {ECO:0000256|RuleBase:RU369067}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family.
CC {ECO:0000256|RuleBase:RU369067}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; KB016396; EPY89529.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR InterPro; IPR026987; Wdr18_C_dom.
DR PANTHER; PTHR18763:SF0; WD REPEAT-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR18763; WD-REPEAT PROTEIN 18; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00400; WD40; 2.
DR Pfam; PF14077; WD40_alt; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Nucleus {ECO:0000256|RuleBase:RU369067};
KW Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|RuleBase:RU369067};
KW Synapse {ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 641..660
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 680..699
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 711..735
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT REPEAT 143..176
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 260..301
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 531..750
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 533..588
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 491..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 83115 MW; E743FBA30D2814F4 CRC64;
MTHVRRGGEG KMAAPMEVAV CTDSTAQLWS CVVWELHSGA NLLTYRGGQA GPRGLALLNG
EYLLAAQLGK NYISAWELQR KDQLQQKIMC PGPVTCLTTS PSGLYVLAGI SESIYLWEVS
TXXXXXXXXX XXXXXTGDFL VILSRHYQDV SCLQFTGDSS HFLSGGKDCL VLVWSLCRPA
LRFWGTPGPG GHCIAGPDSE GELLLSVLFD VGIMAVTMDL AEHHMFCGGS DGSIFQVDLC
TWPGQREKSF QPEQERGKVF RGHRNQVTCL SVSTDGSLLL SGSHDETVRL WDVQSQQCLR
TVTLKGPVTN ASIMLAPVSM LSSDFRPGLP LPRFSKHLLG AEHGDELHRG GFALRLGLHQ
QAPPYGVKFG SARANLLAEG SAQQEANSLS AAATSLGGQA LPTGWRHDLT TRSSVLEDVS
AHPLRRLVSK PLHMVLSLPG PWALGSMLER EAARWRRWDV TELEDEVRNL RKINRDLFDF
STRIITRPAK EESSLQDTAG PLPGQCSVSA CGRPGHEKNP SSFDVEKPRE QGEAGRLAGS
GESQKIQKQW KRLAEDTPFD FQLYIVGDGK YGALRDGRWT GLVGDLLAGR AHMAVTSFSI
NSARSQVVDF SSPFFSTSLG IVVRARDTAA PIGAFMWPLH WSMWLGVFAA LHLTALFLTL
YEWRSPYGLT PRGRNRGTVF SYSSALSLCY AILFGRTAFS KTPKCPTGRL LMNLWAIFCL
LVLSSYTANL AAVIVGDKTF EELSGIHDPK TALLYRLQT
//
