ID S9Y650_CAMFR Unreviewed; 1086 AA.
AC S9Y650;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN ORFNames=CB1_000931009 {ECO:0000313|EMBL:EPY79445.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY79445.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY79445.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; KB017173; EPY79445.1; -; Genomic_DNA.
DR AlphaFoldDB; S9Y650; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 6.10.250.3310; signal transducer and activator of transcription 1; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 2.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR038295; STAT1_C_sf.
DR InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF19; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF12162; STAT1_TAZ2bind; 1.
DR Pfam; PF01017; STAT_alpha; 2.
DR Pfam; PF02864; STAT_bind; 2.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF47655; STAT; 2.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 344..422
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 889..982
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 147..174
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1086 AA; 124239 MW; AF3DC744894B2F9C CRC64;
MAELEVEQPG TVYNPQPVLS LQQSIEEYAV NGKFHGNPMH VAVVISNCLR EERRILAAAN
MPVQGPLEKS LQSSSVSERQ RNVEHKVAAI KNSVQEALSK MTQIVNETDL LMNSMLVEEL
QDWKRRQQIA CIGGPLHSGL DQLQNCFTLL AESLFQLRRQ LEKLEEQSTK MTYEGDPIPL
QRAHLLERVT FLIYNLFKNS FVVERQPCMP THPQRPMVLK TLIQFTVKLR LLIKLPELNY
QVKVKASIDK NVSTLSNRRF VLCGTHVKAM SIEESSNGSL SVEFRHLGCH MVTEELHSIT
FETQICLYGL TIDLEEHLPG KSFTFWTWLE AILDLIKKHI LPLWIDGYVM GFVSKEKERL
LLKDKMPGTF LLRFSESHLG GITFTWVDHS ENGEVRFHSV EPYNKGRLSA LPFADILRDY
KVIMAENIPE NPLKYLYPDI PKDKAFGKHY SSQPCEGISC VPNIPDTHRM SQWYELQQLD
SKFLEQVHQL YDDSFPMEIR QYLAQWLEKQ DWEHAANDVS FATIRFHDLL SQLDDQYSRF
SLENNFLLQH NIRKSKRNLQ AQSGNIQSTV MLDKQKELDS KVRNVKDKVM EVVHKIIELL
NVTELTQKAL INDELVEWKQ RQQSACIGGP PNACLDQLQN WFTIVAESLQ QVRQQLKKLE
ELEQKYTYEH DPITKNKQAL WDRTFSLFQQ LIQRFRKFNI LGTHTKVMNM EESTNGSLAA
EFRHLGPLIV TEELHSLSFE TQLCQPGLVI DLETTSLPVV VISNVSQLPS GWASILWYNM
LVAEPRNLSF FLNPPCARWS QLSEVLSWQF SSVTKRGLNV DQLNMLGEKL LGECCLGFVL
SSSHSPEVAV FLAAVLTALC ADFGLFLSPT EPRGQAVYFP PQKASLQVCI VGFISKERER
ALLKDQQPGT FLLRFSESCR EGAITFTWVE RSQNGGEPYF HAVEPYTKKE LSAVTFPDII
RNYKVMAAEN IPENPLKYLY PNIDKDHAFG KYYSRPKEAP EPMELDGPKG TGYIKTELIS
VSEVHPSRLQ TTDNLLPMSP EEFDEVSRIV GSVEFDTMKH THGNGFVPDA AQLRNAVVPP
KEALAR
//
