ID S9YAR1_CAMFR Unreviewed; 1359 AA.
AC S9YAR1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Striatin-interacting protein 2 isoform a {ECO:0000313|EMBL:EPY81105.1};
GN ORFNames=CB1_000757014 {ECO:0000313|EMBL:EPY81105.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY81105.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY81105.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the STRIP family.
CC {ECO:0000256|ARBA:ARBA00007062}.
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
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DR EMBL; KB017021; EPY81105.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00401; SAHH; 1.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR040185; Far11/STRP.
DR InterPro; IPR021819; Far11/STRP_C.
DR InterPro; IPR012486; Far11/STRP_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR PANTHER; PTHR13239; PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2; 1.
DR PANTHER; PTHR13239:SF6; STRIATIN-INTERACTING PROTEIN 2; 1.
DR Pfam; PF05221; AdoHcyase; 2.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR Pfam; PF11882; DUF3402; 2.
DR Pfam; PF07923; N1221; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SMART; SM01293; DUF3402; 1.
DR SMART; SM01292; N1221; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00738; ADOHCYASE_1; 1.
DR PROSITE; PS00739; ADOHCYASE_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684}.
FT DOMAIN 226..385
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
FT DOMAIN 492..798
FT /note="Far11/STRP N-terminal"
FT /evidence="ECO:0000259|SMART:SM01292"
FT DOMAIN 900..1272
FT /note="Far11/STRP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01293"
FT REGION 20..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1359 AA; 154344 MW; 7A92E097553993EA CRC64;
MEMMMVKLLT AGMKKIQFAD QKQEFNKRPT KIGRRSLSRS ISQSSTDSYS SAASYTDSSD
DETSPRDKQQ KNSKGSSDFC VKNIKQAEFG RREIEIAEQE MPALMALRKR AQGEKPLAGA
KIVGCTHITA QTAVLMETLG ALGAQCRWAA CNIYSTLNEV AAALAESGFP VFAWKGESED
DFWWCIDRCV NVEGWQPNMI LDDGGDLTHW IYKKYPNMFK KIKGIVEESV TGVHRLKRTT
DMMFGGKQVV VCGYGEVGKG CCAALKAMGS IVYVTEIDPI CALQACMDGF RLVKLNEVIR
QVDIVITCTG NKNVVTREHL DRMKNSCIVC NMGHSNTEID VASLRTPELT WERVRSQVDH
VIWPDGKRIV LLAEGRLLNL SCSTVPTFVL SITATTQALA LIELYNAPEG RYKQDVYLLP
KKMDEYVASL HLPTFDAHLT ELTDEQAKYL GLNKNGPFKP NYYRQVLHVP ASPQADNIQS
HLYFSLQGSV DCPTLEFEYG DADGHAAELS ELYSYTENLE FTTNRRCFEE DFKTQVEGKE
WLELEEDAQK AYVMGLLDRL EVVSRERRLK VARAVLYLAQ GTFAECDSEV DVLHWSRYNC
FLLYQMGTFS AFLELLHMEI DNSQACSSAL RKPAISIADS TELRVLLSVL YLMVENIRLE
RETDSCGWRT ARETFRTELS FSTHNEEPFA LLLFSMVTKF CSGLAPHFPI KKVLLLLWKV
VMFTLGGFEH LQALKVQKRA ELGLPPLAED SIQVVKSMRA ASPPSYTLDL GESQLAPPPS
KLRGRRGSRR QLLTKQDSLD IYNERDLFKT EEPATEEEEE SAGDGERTLD GELDLLEQDP
LVPPPPSQAS LSAERVAFPK GLPWAPKVRQ KDIEHFLEMS RNKFIGFTLG QDTDTLVGLP
RPIHESVKTL KQHKYISIAD VQIKNEEELE KCPMSLGEEV VPETPCEILY QGMLYSLPQY
MIALLKILLA AAPTSKAKTD SINILADVLP EEMPNESLEG NISASDWLHS ITVLQSMKLG
IDVNRHKEII VKCISALLLL LLKHFKLNHI YQFEYVSQHL VFANCIPLIL KFFNQNILSY
ITAKNSISVL DYPCCTIQDL PELTTESLEA GDNNQFCWRN LFSCINLLRL LNKLTKWKHS
RTMMLVVFKS APILKRALKV KQAMLQLYVL KLLKIQTKYL GRQWRKSNMK TMSAIYQKVR
HRMNDDWAYG NDIDARPWDF QAEECTLRAN IEAFNSRRYD RPQDSEFSPV DNCLQSVLGQ
RLDLPEDFHY SYELWLEREK LGHYVNKIHL VFIPGLGKGK RKGRGKSREK KQKKPEVDIF
SPAAMLNLYY IAHNVADCLH LRGFRWPGAA KSKKGKNKT
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