ID S9YIQ1_CAMFR Unreviewed; 1979 AA.
AC S9YIQ1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Low-density lipoprotein receptor-related protein 4 {ECO:0000313|EMBL:EPY83990.1};
GN ORFNames=CB1_000515010 {ECO:0000313|EMBL:EPY83990.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EPY83990.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EPY83990.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KB016795; EPY83990.1; -; Genomic_DNA.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 16.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 16.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:EPY83990.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EPY83990.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1798..1821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..508
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 555..597
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 598..640
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 641..684
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 685..727
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 860..902
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 903..945
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 946..989
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 990..1032
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1168..1210
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1211..1253
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1254..1297
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1298..1339
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1472..1514
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1515..1557
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1558..1601
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1602..1643
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1924..1979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1924..1955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..1979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 72..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 92..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 99..117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 111..126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 131..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 138..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 176..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 188..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 212..224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 219..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 231..246
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 285..297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 292..310
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 304..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 324..336
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 331..349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 343..358
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 387..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 394..412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1979 AA; 220288 MW; F1E0F2DC90F499E1 CRC64;
MAPTRREERR EAERVSRKEP PYRNAKLAAL VPDQKVKEGL ASSPECACGR SHFTCAVSAL
GECTCIPAQW QCDGDNDCGD HSDEDGCMLP TCSPLDFHCD NGKCIRRSWV CDGDNDCEDD
SDEQDCPPRE CEEDEFPCQN GYCIRSLWHC DGDNDCGDNS DEQCDTRKCS DKEFRCSDGS
CIAEHWYCDG DTDCKDGSDE ESCPSAVPAP PCNLEEFQCA YGRCILDIYH CDGDDDCGDW
SDESDCYGGA WMLGLCLSGL LWDTACMDWL EIEAYVVSPA SHQPCRSGEF MCDSGLCINA
GWRCDGDADC DDQSDERNCT TSMCTAEQFR CRSGRCVRLS WRCDGEDDCA DNSDEENCEN
TALPCCDLTL PLSPPPTLPP SLGSPQCASD QFLCWNGRCI GQRKLCNGVN DCGDNSDESP
QQNCRPRTGE ESCNVNNGGC TQKCQMVRGA VQCTCHTGYR LTEDGRMCQD VNECAEEGYC
SQGCTNSEGA FQCWCEAGYE LRPDRRSCKA LGPEPVLLFA NRIDIRQVLP HRSEYTLLLN
NLENAIALDF HHRRELVFWS DVTLDRILRA NLNGSNVEEV VSTGLESPGG LAVDWVHDKL
YWTDSGTSRI EVANLDGAHR KVLLWQNLEK PRAIALHPME GTIYWTDWGN TPRIEASSMD
GSGRRIIADT HLFWPNGLTI DYAGRRMYWV DAKHHVIERA NLDGSHRKAV ISQGLPHPFA
ITVFEDSLYW TDWHTKSINS ANKFTGKNQE IIRNKLHFPM DIHTLHPQRQ PAGKNRCGDN
NGGCTHLCLP SGQNYTCACP TGFRKISSHA CAQSLDKFLL FARRMDIRRI SFDTEDLSDD
VIPLADVRSA VALDWDSRDD HVYWTDVSTD TISRAKWDGT GQEVVVDTSL ESPAGLAIDW
VTNKLYWTDA GTDRIEVANT DGSMRTVLIW ENLDRPRDIV VEPMGGYMYW TDWGASPKIE
RAGMDASGRQ VIISSNLTWP NGLAIDYGSQ RLYWADAGMK TIEFAGLDGS KRKVLIGSQL
PHPFGLTLYG ERIYWTDWQT KSIQSADRLT GLDRETLQEN LENLMDIHVF HRRRPPVSTP
CAMENGGCSH LCLRSPNPSG FSCTCPTGIN LMPDGKTCSP GMNSFLIFAR RIDVRMVSLD
IPYFADVVVP INITMKNTIA IGVDPQEGKV YWSDSTLHRI SRANLDGSQH EDIITTGLQT
TDGLAVDAIG RKVYWTDTGT NRIEVGNLDG SMRKVLVWQN LDSPRAIVLY HEMGFMYWTD
WGDNAKLERS GMDGSDRTVL INNNLGWPNG LTVDKASSQL LWADAHTERI EAADLNGANR
HTLVSPVQHP YGLTLLDSYI YWTDWQTRSI HRADKGTGSN VILVRSNLPG LMDIQAVDRA
QPLGFNKCGS RNGGCSHLCL PRPSGFSCAC PTGIQLKGDG KTCDPSPETY LLFSSRGSIR
RISLDTSDHT DVHVPVPELN NVISLDYDSV DGKVYYTDVF LDVIRRADLN GSNMETVIGR
GLKTTDGLAV DWVARNLYWT DTGRNTIEAS RLDGSCRKVL VNNSLDEPRA IAVFPRKGYL
FWTDWGHIAK IERANLDGSE RKVLINTDLG WPNGLTLDYD TRRIYWVDAH LDRIESADLS
GKLRQVLVSH VSHPFALTQD RWIYWTDWQT KSIQRVDKYS GRNKETVLAN VEGLMDIIVV
SPQRQTGTNA CGVNNGGCTH LCFARTSDFV CACPDEPDGR PCSLVPGLVP PAPRVTSMSE
RSPVLPNTLP TTLRSSTTRT RTSLEEVEGR CSEKDARLGL CAHSNEAVPA APGEGLHVSY
VIGGLLSILL ILVVIAALML YRHKKSKLTD PGMGNLTYSN PSYRTSTQEV KIEAIPKPAM
YNQLCYKKEG GPDHNYTKEK VKIVEGICLL SGDEAEWDDL KQLRSSRGGL LRDHVCMKTD
TVSIQASSGS LDDTETEQLL QEEQSECSSV HTAATPERRG SLPDTGWRHE RKLSSESQV
//
