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Database: UniProt
Entry: S9ZQL0_9RHOO
LinkDB: S9ZQL0_9RHOO
Original site: S9ZQL0_9RHOO 
ID   S9ZQL0_9RHOO            Unreviewed;       309 AA.
AC   S9ZQL0;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465, ECO:0000256|RuleBase:RU362068};
DE            EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014, ECO:0000256|RuleBase:RU362068};
DE   AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024, ECO:0000256|RuleBase:RU362068};
GN   ORFNames=M622_10450 {ECO:0000313|EMBL:EPZ16931.1};
OS   Thauera terpenica 58Eu.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC   Thauera.
OX   NCBI_TaxID=1348657 {ECO:0000313|EMBL:EPZ16931.1, ECO:0000313|Proteomes:UP000015455};
RN   [1] {ECO:0000313|EMBL:EPZ16931.1, ECO:0000313|Proteomes:UP000015455}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=58Eu {ECO:0000313|EMBL:EPZ16931.1,
RC   ECO:0000313|Proteomes:UP000015455};
RA   Liu B., Frostegard A.H., Shapleigh J.P.;
RT   "Draft genome sequence of Thauera terpenica.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate into
CC       pantoic acid. {ECO:0000256|ARBA:ARBA00002919,
CC       ECO:0000256|RuleBase:RU362068}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00000784,
CC         ECO:0000256|RuleBase:RU362068};
CC   -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC       pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004994, ECO:0000256|RuleBase:RU362068}.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|ARBA:ARBA00007870, ECO:0000256|RuleBase:RU362068}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPZ16931.1}.
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DR   EMBL; ATJV01000024; EPZ16931.1; -; Genomic_DNA.
DR   RefSeq; WP_021248075.1; NZ_ATJV01000024.1.
DR   AlphaFoldDB; S9ZQL0; -.
DR   STRING; 1348657.M622_10450; -.
DR   PATRIC; fig|1348657.5.peg.628; -.
DR   eggNOG; COG1893; Bacteria.
DR   OrthoDB; 8555723at2; -.
DR   UniPathway; UPA00028; UER00004.
DR   Proteomes; UP000015455; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR003710; ApbA.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR00745; apbA_panE; 1.
DR   PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|RuleBase:RU362068};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU362068};
KW   Pantothenate biosynthesis {ECO:0000256|RuleBase:RU362068};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015455};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          15..148
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          171..293
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   309 AA;  31852 MW;  891627773056E42A CRC64;
     MNTPPTPPSA PYPLAIIGAG ALGLSFATRL ARTGRVAVIA RSAERAQALL QGIEVGGTLR
     HFDVFGADQA PQADWVIVLV KTGDTTEAAL TAAAMAPKGV LSLQNGLVED LLRAACPGLS
     VGQGVTTEGA YRDDSDRVHP SGAGETLLPA GFEAVAELLV GAGFTARVVA DIVPVRLAKL
     LVNAAINPLA ALFRVTNGEL LSAPHRVLLD ALIAEAWPVL HAHGLALDEA TAHARVHAVA
     SATAANRASM LQDVLAGRPT EIDAITGVLF SMADAAGMEV PTHRAVHTLV RTVADARLSP
     AHRRAGLRP
//
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