ID SAM5B_DANRE Reviewed; 469 AA.
AC Q5U3I0;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Sorting and assembly machinery component 50 homolog B;
GN Name=samm50b; Synonyms=samm50l; ORFNames=zgc:103504;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in the maintenance of the structure of
CC mitochondrial cristae. {ECO:0000250|UniProtKB:Q9Y512}.
CC -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC organizing system (MICOS) complex (also known as MINOS or MitOS
CC complex). {ECO:0000250|UniProtKB:Q9Y512}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q9Y512}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- DOMAIN: Its C-terminal part seems to contain many membrane-spanning
CC sided beta-sheets, that have the potential to adopt a transmembrane
CC beta-barrel type structure. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SAM50/omp85 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC085536; AAH85536.1; -; mRNA.
DR RefSeq; NP_001007344.1; NM_001007343.1.
DR AlphaFoldDB; Q5U3I0; -.
DR SMR; Q5U3I0; -.
DR STRING; 7955.ENSDARP00000058006; -.
DR PaxDb; 7955-ENSDARP00000058006; -.
DR GeneID; 492471; -.
DR KEGG; dre:492471; -.
DR AGR; ZFIN:ZDB-GENE-041114-30; -.
DR CTD; 492471; -.
DR ZFIN; ZDB-GENE-041114-30; samm50l.
DR eggNOG; KOG2602; Eukaryota.
DR InParanoid; Q5U3I0; -.
DR OrthoDB; 46657at2759; -.
DR PhylomeDB; Q5U3I0; -.
DR PRO; PR:Q5U3I0; -.
DR Proteomes; UP000000437; Chromosome 4.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IBA:GO_Central.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IBA:GO_Central.
DR Gene3D; 3.10.20.310; membrane protein fhac; 1.
DR Gene3D; 2.40.160.50; membrane protein fhac: a member of the omp85/tpsb transporter family; 1.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR039910; D15-like.
DR InterPro; IPR034746; POTRA.
DR PANTHER; PTHR12815:SF18; SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG; 1.
DR PANTHER; PTHR12815; SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF01103; Omp85; 1.
DR PROSITE; PS51779; POTRA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transmembrane; Transmembrane beta strand.
FT CHAIN 1..469
FT /note="Sorting and assembly machinery component 50 homolog
FT B"
FT /id="PRO_0000383682"
FT DOMAIN 45..125
FT /note="POTRA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ SEQUENCE 469 AA; 52184 MW; 7B10EEB1D9CB71CD CRC64;
MGTVHARSMD SYPMYGRDLG VNTDDMEVME AVQETKQEVL ENKDVVVQHV NIEGLGRTKE
DYLGYEISDV FTARNLVEVM RKSHEARQRL LRLGIFRDVE VVIDISEGAD ALPNGLDVTF
EVTELKRLTG SYNTMVGNNE GSMVLGIKLP NMLGRGEKLT FQFSYGTKET SYGLSFFKPQ
SGYFERNFTV NLYKVTGQFP WSSLKETDRG VSTELSLPLW MTDHTLKWEG VWRELGCLAR
SASFAVREES GHTLKSALSH TMVVDTRNSA ILPRKGALLR INQELAGYTG GDANFLKEDV
ELQLNKQFIW GSVLSASLWG GMIYPLGAQP TSIADRFYLG GPTSVRGFGM YSIGPQSEGD
YLGGEAYWAG GLHLYTPLPF RSNKGGLADL FRTHFFLNAG NICNLNYGEG PRAHLQKLAE
CIRWSYGAGI ILRLGNIARL ELNYCFPMGV QSGDRICDGV QFGAGIRFL
//
