ID SART_STAAN Reviewed; 118 AA.
AC Q7A3K1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=HTH-type transcriptional regulator SarT;
DE AltName: Full=Staphylococcal accessory regulator T;
GN Name=sarT; OrderedLocusNames=SA2286;
OS Staphylococcus aureus (strain N315).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N315;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Transcriptional regulator acting as an intermediary between
CC major regulators SarA and agr and virulence genes. Represses alpha-
CC hemolysin (hla) gene expression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SarA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB43589.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BA000018; BAB43589.1; ALT_INIT; Genomic_DNA.
DR PIR; C90053; C90053.
DR RefSeq; WP_000998872.1; NC_002745.2.
DR AlphaFoldDB; Q7A3K1; -.
DR SMR; Q7A3K1; -.
DR EnsemblBacteria; BAB43589; BAB43589; BAB43589.
DR KEGG; sau:SA2286; -.
DR HOGENOM; CLU_2095348_0_0_9; -.
DR Proteomes; UP000000751; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR039422; MarR/SlyA-like.
DR InterPro; IPR010166; SarA/Rot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01889; Staph_reg_Sar; 1.
DR PANTHER; PTHR33164:SF108; HTH-TYPE TRANSCRIPTIONAL REGULATOR SARR; 1.
DR PANTHER; PTHR33164; TRANSCRIPTIONAL REGULATOR, MARR FAMILY; 1.
DR Pfam; PF12802; MarR_2; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..118
FT /note="HTH-type transcriptional regulator SarT"
FT /id="PRO_0000219599"
FT DNA_BIND 55..78
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
SQ SEQUENCE 118 AA; 14002 MW; 231D70A5D13CF9F7 CRC64;
MNDLKSKSNI KLMKRVLTTY ELRKYLKKYF CLTLDNYLVL AYLDVFKNDE GKYFMRDIIS
YIGIDQSRIV KSVKELSKKG YLNKCRDPHD SRNVIIVVSV KQHNYIKNLL SEININET
//
