ID SEA_AVIET Reviewed; 370 AA.
AC P23049; Q85458; Q85459;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 08-NOV-2023, entry version 100.
DE RecName: Full=Tyrosine-protein kinase transforming protein SEA;
DE EC=2.7.10.2;
GN Name=V-SEA;
OS Avian erythroblastosis virus (strain S13).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus;
OC Avian leukosis virus.
OX NCBI_TaxID=11863;
OH NCBI_TaxID=8976; Galliformes.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2546151; DOI=10.1073/pnas.86.14.5291;
RA Smith D.R., Vogt P.K., Hayman M.J.;
RT "The v-sea oncogene of avian erythroblastosis retrovirus S13: another
RT member of the protein-tyrosine kinase gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:5291-5295(1989).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC -!- MISCELLANEOUS: This protein is synthesized as an Env-Sea polyprotein.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA42392.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M25158; AAA42392.1; ALT_INIT; Genomic_RNA.
DR SMR; P23049; -.
DR BRENDA; 2.7.10.2; 589.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF113; MACROPHAGE-STIMULATING PROTEIN RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein;
KW Transferase; Tyrosine-protein kinase.
FT CHAIN 1..370
FT /note="Tyrosine-protein kinase transforming protein SEA"
FT /id="PRO_0000088136"
FT DOMAIN 60..323
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 345..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 186
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10028"
FT BINDING 66..74
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 92
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 216
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000250"
SQ SEQUENCE 370 AA; 41701 MW; DD02ABBD58BD190D CRC64;
ADSPGLARPH AHFASAGADA AGGGSPVLLL RTTSCCLEDL RPELLEEVKD ILIPEERLIT
HRSRVIGRGH FGSVYHGTYM DPLLGNLHCA VKSLHRITYL EEVEEFLREG ILMKGFHHPQ
VLSLLGVCLP RHGLPLVVLP YMRHGDLRHF VRAQERSPTV KELIGFGLQV ALGMEYLAQK
KFVHRDLAAR NCMLDETLTV KVADFGLARD VFGKEYYSIR QHRHAKLPVR WMALESLQTQ
KFTTKSDVWS FGVLMWELLT RGASPYPEVD PYDMARYLLR GRRLPQPQPC PDTLYGVMLS
CWAPTPEERP SFSGLVCELE RVLASLEGEH YINMAVTYVN LESGPPFPPA PRGQLPDSED
EEDEEEEVAE
//
