ID SHOX2_RAT Reviewed; 237 AA.
AC O35750; O35749; O35751;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 2.
DT 24-JAN-2024, entry version 142.
DE RecName: Full=Short stature homeobox protein 2;
DE AltName: Full=Paired family homeodomain protein Prx3;
DE Flags: Fragment;
GN Name=Shox2; Synonyms=Prx3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryonic brain;
RX PubMed=9371788; DOI=10.1073/pnas.94.24.12993;
RA van Schaick H.S.A., Smidt M.P., Rovescalli A.C., Luijten M.,
RA van der Kleij A.A.M., Asoh S., Kozak C.A., Nirenberg M.W., Burbach J.P.H.;
RT "Homeobox gene Prx3 expression in rodent brain and extraneural tissues.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:12993-12998(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RA Bois P.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a growth regulator and have a role in specifying
CC neural systems involved in processing somatosensory information, as
CC well as in face and body structure formation.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=SHOX2A;
CC IsoId=O35750-1; Sequence=Displayed;
CC Name=2; Synonyms=SHOX2B;
CC IsoId=O35750-2; Sequence=VSP_002290;
CC -!- TISSUE SPECIFICITY: Expression restricted to a few regions in the
CC brain: thalamic, tectal and brainstem structures that include relay
CC nuclei of the visual and auditory systems as well as other ascending
CC systems conveying somatosensory information. Not expressed in kidney,
CC heart, lung, tongue and adrenal gland.
CC -!- DEVELOPMENTAL STAGE: Neural expression in lateral and medial geniculate
CC complex, superior and inferior colliculus, superficial gray layer of
CC the superior colliculus, pontine reticular formation and inferior
CC olive. Also expressed in non-neuronal structures around the oral cavity
CC and in hip and shoulder regions.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA05283.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA05284.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ002258; CAA05283.1; ALT_INIT; mRNA.
DR EMBL; AJ002259; CAA05284.1; ALT_INIT; mRNA.
DR EMBL; AJ002260; CAA05285.1; -; mRNA.
DR RefSeq; NP_037160.1; NM_013028.1.
DR AlphaFoldDB; O35750; -.
DR SMR; O35750; -.
DR STRING; 10116.ENSRNOP00000016843; -.
DR PhosphoSitePlus; O35750; -.
DR jPOST; O35750; -.
DR PaxDb; 10116-ENSRNOP00000016843; -.
DR GeneID; 25546; -.
DR KEGG; rno:25546; -.
DR UCSC; RGD:3674; rat. [O35750-1]
DR AGR; RGD:3674; -.
DR CTD; 6474; -.
DR RGD; 3674; Shox2.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; O35750; -.
DR OrthoDB; 2897127at2759; -.
DR PhylomeDB; O35750; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003209; P:cardiac atrium morphogenesis; ISO:RGD.
DR GO; GO:0060920; P:cardiac pacemaker cell differentiation; ISO:RGD.
DR GO; GO:0003213; P:cardiac right atrium morphogenesis; ISO:RGD.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; ISO:RGD.
DR GO; GO:0002063; P:chondrocyte development; ISO:RGD.
DR GO; GO:0002062; P:chondrocyte differentiation; ISO:RGD.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISO:RGD.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISO:RGD.
DR GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
DR GO; GO:0048598; P:embryonic morphogenesis; ISO:RGD.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISO:RGD.
DR GO; GO:0003170; P:heart valve development; ISO:RGD.
DR GO; GO:0010463; P:mesenchymal cell proliferation; ISO:RGD.
DR GO; GO:0060415; P:muscle tissue morphogenesis; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0001649; P:osteoblast differentiation; ISO:RGD.
DR GO; GO:0050772; P:positive regulation of axonogenesis; ISO:RGD.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISO:RGD.
DR GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; ISO:RGD.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISO:RGD.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:2000172; P:regulation of branching morphogenesis of a nerve; ISO:RGD.
DR GO; GO:0032330; P:regulation of chondrocyte differentiation; ISO:RGD.
DR GO; GO:0002027; P:regulation of heart rate; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060931; P:sinoatrial node cell development; ISO:RGD.
DR GO; GO:0003163; P:sinoatrial node development; ISO:RGD.
DR GO; GO:0003172; P:sinoatrial valve development; ISO:RGD.
DR GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR GO; GO:0072089; P:stem cell proliferation; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR46255; SHORT STATURE HOMEOBOX; 1.
DR PANTHER; PTHR46255:SF1; SHORT STATURE HOMEOBOX PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome.
FT CHAIN <1..237
FT /note="Short stature homeobox protein 2"
FT /id="PRO_0000049294"
FT DNA_BIND 46..105
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 219..232
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT VAR_SEQ 141..152
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9371788, ECO:0000303|Ref.2"
FT /id="VSP_002290"
FT CONFLICT 11..21
FT /note="SREPGSPRLTE -> HTCGPSVVPSS (in Ref. 1; CAA05285)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="P -> G (in Ref. 1; CAA05285)"
FT /evidence="ECO:0000305"
FT NON_TER 1
SQ SEQUENCE 237 AA; 26221 MW; 96702BF3A25A144A CRC64;
RELDMGAAER SREPGSPRLT EVSPELKDRK EDAKGMEDEG QTKIKQRRSR TNFTLEQLNE
LERLFDETHY PDAFMREELS QRLGLSEARV QVWFQNRRAK CRKQENQLHK GVLIGAASQF
EACRVAPYVN VGALRMPFQQ DSHCNVTPLS FQVQAHVQLD SAVRAAHHHL HPHLAAHGPY
MMFPAPPFGL PLATLAADSA SAASVVAAAA AAKTTSKNSS IADLRLKAKK HAAALGL
//
