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Database: UniProt
Entry: SLYA_YERPS
LinkDB: SLYA_YERPS
Original site: SLYA_YERPS 
ID   SLYA_YERPS              Reviewed;         143 AA.
AC   P69989; Q66A44; Q9AM39;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   24-JAN-2024, entry version 100.
DE   RecName: Full=Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule:MF_01819};
DE   AltName: Full=Regulator of virulence protein A;
DE   AltName: Full=Transcriptional regulator for cryptic hemolysin;
GN   Name=slyA {ECO:0000255|HAMAP-Rule:MF_01819}; Synonyms=rovA;
GN   OrderedLocusNames=YPTB2288;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=11580832; DOI=10.1046/j.1365-2958.2001.02522.x;
RA   Nagel G., Lahrz A., Dersch P.;
RT   "Environmental control of invasin expression in Yersinia pseudotuberculosis
RT   is mediated by regulation of RovA, a transcriptional activator of the
RT   SlyA/Hor family.";
RL   Mol. Microbiol. 41:1249-1269(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Transcription regulator that can specifically activate or
CC       repress expression of target genes. Required for expression of the
CC       virulence gene inv. {ECO:0000255|HAMAP-Rule:MF_01819,
CC       ECO:0000269|PubMed:11580832}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01819}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000269|PubMed:11580832}.
CC   -!- SIMILARITY: Belongs to the SlyA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01819}.
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DR   EMBL; AF330139; AAK01704.1; -; Genomic_DNA.
DR   EMBL; BX936398; CAH21526.1; -; Genomic_DNA.
DR   RefSeq; WP_002210955.1; NZ_CP009712.1.
DR   AlphaFoldDB; P69989; -.
DR   SMR; P69989; -.
DR   GeneID; 66841281; -.
DR   KEGG; ypo:BZ17_172; -.
DR   KEGG; yps:YPTB2288; -.
DR   PATRIC; fig|273123.14.peg.179; -.
DR   OMA; CSNDRRA; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_01819; HTH_type_SlyA; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR039422; MarR/SlyA-like.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR023071; Tscrpt_reg_SlyA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33164:SF64; TRANSCRIPTIONAL REGULATOR SLYA; 1.
DR   PANTHER; PTHR33164; TRANSCRIPTIONAL REGULATOR, MARR FAMILY; 1.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..143
FT                   /note="Transcriptional regulator SlyA"
FT                   /id="PRO_0000054399"
FT   DOMAIN          2..135
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
FT   DNA_BIND        49..72
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01819"
SQ   SEQUENCE   143 AA;  16170 MW;  62485065D1F5A451 CRC64;
     MESTLGSDLA RLVRVWRALI DHRLKPLELT QTHWVTLYNI NRLPPEQSQI QLAKAIGIEQ
     PSLVRTLDQL EEKGLITRHT CANDRRAKRI KLTEQSSPII EQVDGVICST RKEILGGISS
     DEIAVLSGLI DKLEKNIIQL QTK
//
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