ID SPC25_CRYNB Reviewed; 272 AA.
AC P0CR67; Q55S37; Q5KGI8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Probable kinetochore protein SPC25;
GN Name=SPC25; OrderedLocusNames=CNBE3450;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC NDC80, NUF2 and SPC25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40014}.
CC Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P40014}.
CC Note=Associated with kinetochores. {ECO:0000250|UniProtKB:P40014}.
CC -!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
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DR EMBL; AAEY01000028; EAL20424.1; -; Genomic_DNA.
DR RefSeq; XP_775071.1; XM_769978.1.
DR AlphaFoldDB; P0CR67; -.
DR SMR; P0CR67; -.
DR EnsemblFungi; AAW43605; AAW43605; CNE03460.
DR GeneID; 4936355; -.
DR KEGG; cnb:CNBE3450; -.
DR VEuPathDB; FungiDB:CNBE3450; -.
DR HOGENOM; CLU_093947_0_0_1; -.
DR OrthoDB; 2727887at2759; -.
DR GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR Gene3D; 3.30.457.50; Chromosome segregation protein Spc25; 1.
DR InterPro; IPR045143; Spc25.
DR InterPro; IPR013255; Spc25_C.
DR PANTHER; PTHR14281:SF0; KINETOCHORE PROTEIN SPC25; 1.
DR PANTHER; PTHR14281; KINETOCHORE PROTEIN SPC25-RELATED; 1.
DR Pfam; PF08234; Spindle_Spc25; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Mitosis; Nucleus.
FT CHAIN 1..272
FT /note="Probable kinetochore protein SPC25"
FT /id="PRO_0000410295"
FT COILED 62..174
FT /evidence="ECO:0000255"
SQ SEQUENCE 272 AA; 30873 MW; 94FB54CBAA4F1722 CRC64;
MAPTTYAVPP RPASLHFLLE SSTSKNGVPS LDLRWEPFQR HIESFLNAID AYTQAARTEI
VARATDHTAA VRDLKADKEE MERGIQLQRE SEGEMLATLE AERHVVADLN ASLSHLQSSL
TKIKEKSSAL DAELQSERKE VKAMQAEKER QTNVLNNMRE RDTTELKQLE EALGWRVEGI
KQDQLLMRFT LIDPEDPARE FSIIVDVSKQ VYSVPNCDPP IPSLPDLVRQ LNFDRDLFAF
IKRVRIAFRA LIPNPPNPST KFDDLTGPSR SR
//
