ID SPG21_RAT Reviewed; 261 AA.
AC Q5XIC4;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE RecName: Full=Maspardin;
DE AltName: Full=Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog;
GN Name=Spg21;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role as a negative regulatory factor in CD4-
CC dependent T-cell activation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CD4. Interacts with ALDH16A1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR EMBL; BC083760; AAH83760.1; -; mRNA.
DR RefSeq; NP_001006988.1; NM_001006987.1.
DR AlphaFoldDB; Q5XIC4; -.
DR SMR; Q5XIC4; -.
DR STRING; 10116.ENSRNOP00000069701; -.
DR ESTHER; ratno-SPG21; Maspardin-ACP33-SPG21_like.
DR iPTMnet; Q5XIC4; -.
DR PhosphoSitePlus; Q5XIC4; -.
DR jPOST; Q5XIC4; -.
DR PaxDb; 10116-ENSRNOP00000039361; -.
DR DNASU; 300791; -.
DR Ensembl; ENSRNOT00000051504.4; ENSRNOP00000039361.2; ENSRNOG00000015019.7.
DR Ensembl; ENSRNOT00055042051; ENSRNOP00055034287; ENSRNOG00055024455.
DR Ensembl; ENSRNOT00060027964; ENSRNOP00060022488; ENSRNOG00060016310.
DR Ensembl; ENSRNOT00065011724; ENSRNOP00065008567; ENSRNOG00065007490.
DR GeneID; 300791; -.
DR KEGG; rno:300791; -.
DR UCSC; RGD:1359141; rat.
DR AGR; RGD:1359141; -.
DR CTD; 51324; -.
DR RGD; 1359141; Spg21.
DR eggNOG; ENOG502QPSD; Eukaryota.
DR GeneTree; ENSGT00390000007857; -.
DR InParanoid; Q5XIC4; -.
DR OrthoDB; 276364at2759; -.
DR PRO; PR:Q5XIC4; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000015019; Expressed in lung and 19 other cell types or tissues.
DR ExpressionAtlas; Q5XIC4; baseline and differential.
DR Genevisible; Q5XIC4; RN.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0030140; C:trans-Golgi network transport vesicle; ISS:UniProtKB.
DR GO; GO:0042609; F:CD4 receptor binding; ISS:UniProtKB.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR026151; Maspardin.
DR PANTHER; PTHR15913; ACID CLUSTER PROTEIN 33; 1.
DR PANTHER; PTHR15913:SF0; MASPARDIN; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..261
FT /note="Maspardin"
FT /id="PRO_0000227984"
FT DOMAIN 87..159
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000255"
FT MOD_RES 257
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZD8"
SQ SEQUENCE 261 AA; 29576 MW; 000E08692F45E1C0 CRC64;
MGEIKVSPDY NWFRSTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF
QQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
YTHKSPRVHS LILCNAFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA
IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDIHLLQFH GTKYAAIDPS
VVSAEELDVQ KGQLDLSQEE P
//
