ID SPT6_GIBZE Reviewed; 1408 AA.
AC Q4HYQ4; A0A0E0RVD1; V6RPP5;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=Transcription elongation factor SPT6;
DE AltName: Full=Chromatin elongation factor SPT6;
GN Name=SPT6; ORFNames=FGRRES_09904, FGSG_09904;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000305}.
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DR EMBL; DS231669; ESU16548.1; -; Genomic_DNA.
DR EMBL; HG970332; CEF75206.1; -; Genomic_DNA.
DR RefSeq; XP_011318810.1; XM_011320508.1.
DR AlphaFoldDB; Q4HYQ4; -.
DR SMR; Q4HYQ4; -.
DR STRING; 229533.Q4HYQ4; -.
DR GeneID; 23556830; -.
DR KEGG; fgr:FGSG_09904; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G06803; -.
DR eggNOG; KOG1856; Eukaryota.
DR HOGENOM; CLU_001680_0_1_1; -.
DR InParanoid; Q4HYQ4; -.
DR OrthoDB; 170310at2759; -.
DR PHI-base; PHI:1601; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd00164; S1_like; 1.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR049540; Spt6-like_S1.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF21710; Spt6_S1; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; SH2 domain; Transcription;
KW Transcription regulation.
FT CHAIN 1..1408
FT /note="Transcription elongation factor SPT6"
FT /id="PRO_0000238576"
FT DOMAIN 1101..1168
FT /note="S1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT DOMAIN 1213..1314
FT /note="SH2"
FT REGION 1..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 162213 MW; 8CB31D52E5DFE1BF CRC64;
MSNSMRDLIS GEAELDDEEE DESFDERGGQ RRHKNAVEDS SEEEEDDDDE EEARKVREGF
IVDEDEDEDE GGESDADVRP LHKRKREHRD REEEAQLDED DLDLIGEQFG ERPKPTTQSK
FKRLKRGTRD EDRGNQRRGL DDIFSDEEDD AGEQRAYNNR SSYRQADEFD DFIEEDFPDD
PEELEQQRED AEVARPRDRV IGNIADTANL DKDALDDMEA IFGNGEDYDW ALQMEEEEED
REREEQAIEL KDVFEPSQLK EKLLTDEDNE IRFTDEPERF QIDRKTFKSL QLTAEQFKEE
ARWITNQLWP KKGLASDLQS PFGKAVGKVL EFFIVDEVEV PYVFQHRKDY LLHTRKTRNP
NRDDPDAPEY VISADKLLNQ DDLWKILELD IKFRSFVDKR NALEKTVDNL KGMEIHDAMV
DEMIPEATTM EELQDLQDYL HFQYGQQLKD LAALAGNLSL TKRPGSKSNL LERVRQGKAY
GFVRAYGISA DQLAKNALRH GKKVTPDDDA QYPMDLADSL IDDVFSTGDQ VISAARQMYS
EELFASPRMR KHFRNSYYQA AEISCRRTEK GLRRIDDSHP YYEIKYLQNQ AIADLVHQPE
LFLKMMKAEE EGLVTIKLDM PARYDFRQHL YQEFESENFS DRAEQWREER KKVLDLAYPK
LEKIIAKNVK EVIRTFCQDE VLKMCREEYA KRLDQAPYKP KGMILGTTPR VLVLSNGMSD
PARDPICWAW VEEDGRVIEQ GKLGNLARDE RQREEFEELV KRRRPDVIGV SGWSAETTKL
VRDLEGLVNE KGLMGPEFED PDTNDYRTEP LEVVVVNDEV ARLYKDSPRA LAEHPSLNPI
TRYCVALARY MQNPMKEYAA LGKDVSSLSY HPCQNLLPAD KLAKYLDSAM VDMVNLCGVD
INEAMNDTYT ANLLPYVSGL GPRKATSVIK AINANGGAVG TRDELVGDPD SGKLPVVGPR
VWNNCASFLF IEYEATNPSS DPLDNTRVHP EDYELGRKMA ADALELDEED VKGETDENGP
GAIVRKLFKM DEQDKVNELV LEEYAEQLER NYSQRKRATL ETIRAELQAP YEELRRNFAL
LSASEIFTMF TGETKHTLCE GMIVPVNVRV VKDDFAIVKL DCGIEGRVEG HEVSHRSSIK
EVLSSGQTSQ AKILDINYKD FMAKLSMRED ALRIPYKRPI NLGRDGWDYV LEAADKEELR
EKDKTTGRTQ RVVKHPNFKP FNGLQAEEYL GSQPNGEVVI RPSSKGNDHL AVTWKVADGV
FQHIDVLEMQ KETEFAVGKL LRVGGKYTYT DLDELIVEHV KAMARKVEEL MRHDKYQNRS
RGETEKWLTT YIDANPNRST YAFCIDTKHP GYFWLCFKAS RAAKVIALPV RAIPQGFELK
GYQYPDMRAL CNGFKLRYQN EFSKMGQR
//
