ID SSPO_RAT Reviewed; 5141 AA.
AC Q700K0;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=SCO-spondin;
DE Flags: Precursor;
GN Name=Sspo {ECO:0000312|RGD:1549716};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Meiniel O.;
RT "Conservation of mammalian SCO-spondin.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the modulation of neuronal aggregation (By
CC similarity). May be involved in developmental events during the
CC formation of the central nervous system (By similarity).
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:P98167}.
CC -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
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DR EMBL; AJ629845; CAF33425.1; -; mRNA.
DR RefSeq; NP_001007017.1; NM_001007016.1.
DR SMR; Q700K0; -.
DR IntAct; Q700K0; 1.
DR STRING; 10116.ENSRNOP00000037189; -.
DR GlyCosmos; Q700K0; 43 sites, No reported glycans.
DR GlyGen; Q700K0; 43 sites.
DR PhosphoSitePlus; Q700K0; -.
DR PaxDb; 10116-ENSRNOP00000037189; -.
DR Ensembl; ENSRNOT00000035906.4; ENSRNOP00000037189.2; ENSRNOG00000025848.5.
DR GeneID; 474348; -.
DR KEGG; rno:474348; -.
DR UCSC; RGD:1549716; rat.
DR AGR; RGD:1549716; -.
DR CTD; 243369; -.
DR RGD; 1549716; Sspo.
DR eggNOG; KOG1215; Eukaryota.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG3509; Eukaryota.
DR eggNOG; KOG3538; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT00940000155829; -.
DR HOGENOM; CLU_223278_0_0_1; -.
DR InParanoid; Q700K0; -.
DR OMA; QTKNELC; -.
DR OrthoDB; 2872912at2759; -.
DR PhylomeDB; Q700K0; -.
DR TreeFam; TF344272; -.
DR Reactome; R-RNO-5173214; O-glycosylation of TSR domain-containing proteins.
DR PRO; PR:Q700K0; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000025848; Expressed in adult mammalian kidney and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 9.
DR CDD; cd19941; TIL; 14.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 9.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 24.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF373; HEMOLECTIN, ISOFORM A; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF01826; TIL; 12.
DR Pfam; PF00090; TSP_1; 22.
DR Pfam; PF00093; VWC; 1.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00192; LDLa; 10.
DR SMART; SM00209; TSP1; 25.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 9.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57603; FnI-like domain; 4.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 10.
DR SUPFAM; SSF57567; Serine protease inhibitors; 15.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 25.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 8.
DR PROSITE; PS50068; LDLRA_2; 10.
DR PROSITE; PS50092; TSP1; 24.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 3.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..5141
FT /note="SCO-spondin"
FT /id="PRO_0000245044"
FT DOMAIN 18..102
FT /note="EMI"
FT DOMAIN 193..364
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 472..527
FT /note="TIL 1"
FT /evidence="ECO:0000255"
FT DOMAIN 565..738
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 830..883
FT /note="TIL 2"
FT /evidence="ECO:0000255"
FT DOMAIN 1017..1187
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1280..1336
FT /note="TIL 3"
FT /evidence="ECO:0000255"
FT DOMAIN 1380..1417
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1420..1456
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1456..1492
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1496..1534
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1569..1605
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1607..1646
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1660..1700
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1699..1753
FT /note="TSP type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1755..1970
FT /note="TSP type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 1829..1868
FT /note="EGF-like 1"
FT DOMAIN 1869..1895
FT /note="EGF-like 2"
FT DOMAIN 1970..2030
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 2070..2226
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DOMAIN 2235..2271
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2391..2427
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2448..2484
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2485..2538
FT /note="TSP type-1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2540..2595
FT /note="TSP type-1 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2618..2660
FT /note="TIL 4"
FT /evidence="ECO:0000255"
FT DOMAIN 2700..2754
FT /note="TSP type-1 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2758..2813
FT /note="TSP type-1 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2815..2868
FT /note="TSP type-1 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 2969..3024
FT /note="TSP type-1 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3025..3068
FT /note="TSP type-1 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3075..3127
FT /note="TIL 5"
FT /evidence="ECO:0000255"
FT DOMAIN 3168..3235
FT /note="TSP type-1 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3237..3292
FT /note="TSP type-1 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3300..3350
FT /note="TIL 6"
FT /evidence="ECO:0000255"
FT DOMAIN 3393..3455
FT /note="TSP type-1 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3457..3512
FT /note="TSP type-1 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3514..3570
FT /note="TIL 7"
FT /evidence="ECO:0000255"
FT DOMAIN 3630..3678
FT /note="TSP type-1 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3806..3862
FT /note="TSP type-1 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3876..3928
FT /note="TSP type-1 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 3942..3998
FT /note="TSP type-1 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4000..4055
FT /note="TSP type-1 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4058..4113
FT /note="TIL 8"
FT /evidence="ECO:0000255"
FT DOMAIN 4155..4208
FT /note="TSP type-1 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4249..4304
FT /note="TSP type-1 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4306..4362
FT /note="TSP type-1 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4364..4418
FT /note="TSP type-1 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4422..4477
FT /note="TIL 9"
FT /evidence="ECO:0000255"
FT DOMAIN 4608..4659
FT /note="TSP type-1 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4673..4719
FT /note="TIL 10"
FT /evidence="ECO:0000255"
FT DOMAIN 4759..4812
FT /note="TSP type-1 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 4814..4868
FT /note="TIL 11"
FT /evidence="ECO:0000255"
FT DOMAIN 4920..4978
FT /note="TIL 12"
FT /evidence="ECO:0000255"
FT DOMAIN 4978..5036
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 5047..5134
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 1533..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2262..2335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1540..1567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2277..2291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 657
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 822
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 895
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 949
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 991
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1357
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1655
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1668
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1725
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1814
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2035
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2630
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2679
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2921
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2951
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3046
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3384
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3506
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3584
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3611
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3787
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3910
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4345
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4416
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4557
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4727
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4744
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4749
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4899
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4942
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4949
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5055
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 195..325
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 217..363
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 239..245
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 567..700
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 591..737
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1019..1151
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1041..1186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1062..1069
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1381..1394
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1388..1407
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1401..1416
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1421..1433
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1428..1446
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1440..1455
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1457..1469
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1464..1482
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1476..1491
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1497..1509
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1504..1522
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1516..1533
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1570..1582
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1577..1595
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1589..1604
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1608..1621
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1615..1634
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1628..1645
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1661..1671
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1666..1684
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1678..1699
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 1711..1747
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1715..1752
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1726..1737
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1767..1964
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1771..1969
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 1781..1791
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2070..2226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DISULFID 2236..2248
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2243..2261
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2255..2270
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2392..2404
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2399..2417
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2411..2426
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2449..2461
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2456..2474
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2468..2483
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 2486..2522
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2497..2501
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2532..2537
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2552..2589
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2556..2594
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2567..2579
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2701..2739
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2712..2716
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2749..2753
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2769..2807
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2773..2812
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2789..2797
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2827..2862
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2831..2867
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2842..2852
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2970..3008
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 2981..2985
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3018..3023
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3180..3229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3184..3234
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3195..3219
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3249..3286
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3253..3291
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3264..3276
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3405..3448
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3409..3454
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3420..3432
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3469..3504
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3472..3511
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3482..3494
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3642..3672
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3646..3677
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3657..3662
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3818..3856
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3822..3861
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3834..3846
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3943..3979
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3954..3958
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 3992..3997
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4012..4049
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4016..4054
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4027..4039
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4156..4192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4167..4171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4202..4207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4261..4298
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4265..4303
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4276..4288
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4365..4402
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4376..4378
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4412..4417
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4609..4643
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4620..4624
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4653..4658
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4771..4806
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4775..4811
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 4786..4795
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 5047..5095
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5061..5112
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5071..5128
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 5075..5130
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 5141 AA; 550649 MW; 1772AE67F02CA5E3 CRC64;
MLLPALLFGM LWAPANGHWC EQIETVHVEE EVTPRREDLV PCTSLYHYSR LGWKLDLSWG
GHVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG IHCTEALAEA SPKGHCFVTW
HCQPLAGSAN SSAGSLEECC AQPWGHSWWN SSSQMCLSCS GQHRPGNASS EGLLQPLAGA
VGQLWSQRQR PSATCATWSG FHYQTFDGQH YHFLGQCTYL LAGAMDSTWA VHLRPSVHCP
QPRQCWLVQV IMGPEEVLIQ DGEVSVKGQP VPVGESQLLH GMSLQWQGDW LVLSGGLGVV
VRLDRSSSII ISVDHEFWGR TQGLCGLYNG RPEDDFVEPG GGLAMLAATF GNSWRLPGYE
PGCLDTVEVA RGCEGLLEGT LTGLEAGKLQ AQAQDLCHQL LEDPFSQCHG QVPPDEYHET
CLFAYCVGAT AGSGPEEQVK AVCATFANYA QACARQHIYV HWRKPGFCER LCPGGQLYSD
CISSCPPSCS AVAQGEEGSC GKECVSGCEC PTGLFWDGAL CVPAAHCPCY YRRQRYAPGD
TVKQQCNPCV CQDGRWHCAQ APCPAECAVG GDGHYCTFDG RSFSFRGNPG CQYSLVQDSV
KGQLLVVLEH GACETGSCLH ALSAFLGKTH IQLRYSGAVL VDGQDVDLPW IGAEGFNVSH
ASSTFLLLRW PGAWVLWGVA DPAVYITLDP RHAYQVQGLC GTFTWKQQDD FLTPAGDIET
SVTAFASKFQ VSGDGRCPLV DNTPLSSCST YSQRLAFAEA ACAALHGHAF QECHGLVERE
PFRLRCLESM CSCAPGRDCL CSVLSAYAHH CAQEGVLLQW RNETLCSVPC PGGQVYQECA
PACGHYCGEP EDCKELGSCV AGCNCPPGLL WDLEGQCVPP SMCPCQLGGH RYAFNTTTTL
KDCSHCICQE RGLWNCIAHH CPRQWALCPQ ELIYAPGACL LTCDSLGANH SCLAGSTDGC
VCPSGTVLLD KHCVSPDLCP CRHNGQWYPP NATIQEDCNI CVCQNQRWHC TGQRCSGWCQ
ASGAPHYVTF DGLVFTFPGA CEYLLVREAG GRFSVSIQNL PCGASGLTCT KALAVRLDST
VVHMLRGQAV TVNGVSIKLP KVYTGPGLSL HHAGLFLLLT TRLGLTLLWD GGTRVLVQLS
PHFHGRVTGL CGNFDGDVSN DLRSRQGVLE PTAELTAHSW RLNPLCPEPG DLPHPCSVNA
HRVNWARAHC EVILQPIFAP CHTEVPPQQY YEWCVYDACG CDTGGDCECL CSAIATYADE
CARHRHHVRW RSQELCPLQC EGGQVYEPCG STCPPTCHDH HPELRWHCQA ITCVEGCFCP
EGTLLHGGTC VELTDCPCEW QGSFFPPGAV LQKDCGNCTC QESQWHCNPS GAPCEEMEPG
CAEGEALCRE SGHCVPLEWL CDNQDDCGDG SDEEGCDTSV CGEGQMSCQS GRCLPLSLIC
DGQDDCGDGT DEQGCLCPQG FLACADGRCL PPALLCDGHP DCLDAADEES CLGWVSCTSG
EVSCVDGPCI RTIQLCDGVW DCPDGADEGP VHCSSPSLPT PPAGIGQNPS TSSPDTSPSP
VGSASPASPC SLSEFQCNSG ECTPRGWRCD REEDCTDGSD ELDCGGPCKL YQMPCAHGPH
CLSPGQLCDG VAQCPDGSDE DPDVCEERSA SGGPNGTAVP CPEFSCPNGT CIDFLLVCDG
SPDCELADET EPSLDEQGCG TWGSWGPWEP CSQTCGPGIQ SRNRNCSISS LHVLQNCPGL
QHQSQSCFTE ACPVDGEWSS WSLWSPCSEP CGGTMTRHRQ CRPPQNGGQD CALLPGSTHS
THQTSPCPQE GCLNVTCFGE LVFRPCAPCP LTCDDISGEA VCSPDRPCSS PGCWCPEGKV
LGTEGRCVRP RQCPCLVDGI RYWPGQRIKM DCQLCFCQDG QPHRCRPNPE CAVDCGWSSW
SPWAECLGPC SSQSLQWSFR SPNNPRLSGH GRQCRGIHRK ARRCQTEPCE GCEQWGLTYH
VGERWRGGPC TVCECLHRSI TRCSPYCPIG SCPQSWVLVE GMGESCCHCA LPGKNQTMIP
VTTPAPVPTP SPQIGASLVT YVLPPMSDAC YSPLGLAGLP TWAPSQPLEH STRAAPVEAP
TAGPGPREDA YAEWHTQPLY LQLDLLWPRN LTGIMVQRAG SSAAYISNLS LQFSSDGLQW
HSVLNSLSST LPPPKPSPES SNHMVPEVWT FDQMVQARYI RVWPHGSHLR DNNQQDIFLW
VELLGCKPVP PLAPLCPGTR HRCANGDCAL KGGPCDGAVD CEDGSDEEGC GPLRASTASR
VHSTARTPAL SPTQPGKFPF HPREGLADME HQQPKQESPM PSAGVSPSAS EGLLPVSGQS
MQTLTTTSTF PPGLKSLHPG MAAVTVHSPH SVMPGTPVGQ SVSPRPFPLM RCGPGQVPCD
VLGCVEQEQL CDGREDCLDG SDEQHCASPE PFTVPTTALP GLPASRALCS PSQLSCGSGE
CLPLEHRCDL QVNCQDGSDE DDCVDCVLAP WSGWSDCSRS CGLGLIFQHR ELLRPPLPGG
SCLLDQLRSQ PCFVQACPVA GAWAKWGPWE PCSVSCGGGH QSRQRSCVDP PPKNGGAPCP
GPSHEKVLCN LQLCPGDTDC EPGRVHVNAE LCQKGLLPPC PPSCLDPEAN RSCSGHCVEG
CRCPPGLFLQ DSHCLPLSEC PCLVGQKLMQ PGLAFLLDNC SQCICESGIL LCKPAACSQS
CGWSAWSPWT ACDHSCGSGV RARFRSPTNP PAAFGGSPCE GDRQELQACY TDCGTDIPGW
TPWTSWSSCS QSCLVPGGDP GRRQRSRLCP SSRDTFCPGE ATQEEPCSPS LCPVPSAWGL
WASWSACSAS CNGGIQTRGR SCSGSAPGNP VCLGPHTQTR DCNVHPCTAQ CPGNMVFRSA
EKCLEEGGPC PQLCLAQDPG VECTGSCAPG CSCPPGLFLH NASCLPRSQC PCQLHGQLYA
PGAVARLDCN NCTCSSGEMV CTSERCPVAC GWSPWTPWSP CSQSCNVGIR RRFRAGTAPP
AAFGGAECRG PNLDAEFCTL RPCQGPGAAW SSWTPCSVPC GGGYRNRTQG SGRHSPVEFS
TCSLQPCAGP VPGVCPKDQQ WLDCAQGPAS CAHLSTPREA NQTCHPGCYC LSGMLLLNNV
CVPAQDCPCA HRGRLHSPGS AVILPCENCS CVSGLITNCS SWPCEEGQPA WSSWTPWSVC
SASCSPARRH RRRFCVRPST TAPFSLDLPT TVAAPTMLCP GPEAEEEPCL LPGCNQAGVW
GPWSPWSGCS RSCGGGLRSR TRACDKPPPQ GLGDFCEGPQ AQGEACQAQP CPVANCSTIE
GAEYSPCGPP CPRSCDDLVH CMWHCQPGCY CPPGKVLSAD GAICVQPHHC SCLDLLTGKR
HHPGSQLMRP DGCNHCTCME GRLNCTDLPC QVSGDWCPWS EWTACSQPCR GQTRTRSRAC
VCPAPQHGGA PCPEEAGETG VQHQMEACPN PTACPVDGAW SPWGSWSPCD ACLGQSYRSR
MCSHPPPSDG GTPCLGGHQQ SRPCRNSSTP CTDCGGGQDL LPCGQPCPHS CQDLSLGSTC
QPGSSGCQSG CGCPPGQLSQ DGLCVFPADC HCHFQPKAMG IPENQSRSVG SALSSWESLE
PGEVVTGPCD NCTCVAGVLQ CHEVPSCPGP GIWSSWGPWE KCSVPCGGGE QLRSRQCARP
PCPGLAQQSR TCHIHVCRET GCPAGRLYRE CQPSEGCPFS CAHVTGQVAC FSESCEEGCH
CPEGTFQHHS ACVQECPCVL TVSLLQELGV ASTALRSYPV LLGDEGQPLG PGDELDPGQM
LQTVCGNCSC VHGKLSCSME ECSRVRGYFG PWGMWSLCSH SCGGLGTRTR TRQCVLPTLA
PAGLSCRGPL QDLEYCFSPE CPGTAGSTVE PVTGLAGGWG PWSPWSPCSH SCTDLTHPAW
RSRTRLCLAN CTVGDSSQER PCNLPSCTTL PLCPGPGCGS ENCFWTSWAP WEPCSRSCGV
GQQRRLRAYH PPGPGGHWCP DILTAYQERR FCNLRACPVP GGWSHWSPWS WCDRSCGGGR
SLRSRSCSSP PPKNGGASCV GERHHVRSCN PMPCEKDCPA GMEMVSCANR CPYSCSDLQE
AVMCQEDQAC QLGCRCSEGF LEQDGGCVPV GHCECTDAQG RSWAPGSQHQ DACNNCSCQA
GQLSCTAQPC PPPAHCAWSH WSAWSACSHS CGPHGQQSRF RSSTSGSWAL ECQKEQSQSQ
PCPEDPCPPL CLHEAHLHVL GDNWLHGECQ QCSCTPEGVI CKDTDCAVPG GWTLWSSWSY
CSVSCGGGSQ VRTRSCMVSA PQHGSPSCQG PDTQTQHCGQ QLCLQLLEIC SWGPWGPCSR
SCGTGLASRS GSCPCLLTKE DSECNDTFSG LDTQACYPGP CQEDCMWSDW SSWTRCSCKI
LVQQRYRHQV PAPGQAGEGT LCTGLDGHFR PCAIGNCSED SCLPPFEFQS CGSPCAGLCA
THLSHQLCQD LPPCQPGCYC PMGLLEQDGG CILPEQCNCW HTSGEGARVT LAPGHRLQLG
CKECVCQSGE LQCSSQGCEG LLPLTGWSEW SPCGPCLPQS ALAPDSRTAL EVHWPLNTSV
TLLASEQYRH RLCLDPETGR PWAGDPALCT VPLSQQRLCS DPGACHDTCQ WGPWGPWSPC
QVPCSGGFKL RWREASDNSV GECRGPWAQT ESCNMGSCPG ESCETRDTVF TLDCANQCPR
SCADLWEGVQ CLQGPCSPGC RCPPGQLVQD GHCVPISSCR CGLPSANASW ELAPTQVVQL
DCHNCTCING TLMCPYPECP VLGPWSPWSE CSAVCGGGTM VRYRSCEEHP DSAPCQALDM
EQRVECNLQT CPECPPGQVL STCATLCPSF CSHLWPGTIC VREPCQLGCG CPGGQLLHSG
TCIPPEACPC TRLSLPWGLT LPLEEQAQEL PSGTVLTWNC THCTCQGGVF TCSHTDCQEC
PPGEILQLGE LRPCEKTCLE MNKTQAWSNC TEAQVPGCVC QLGHFRSHTG LCVPEDHCEC
WHHGSPHLPG SEWQEACESC RCLHGKSVCT QHCPELSCAQ GEVVVQEPGS CCPICQQDTL
EEEPVSCRHL TELRNLTKGP CHLDQVEVSY CSGHCRSSTN VMTEEPYLQS QCDCCSYRLD
PDSPVRILNL LCPDGRTEPV LLPVIHNCHC SACQGGEFSK H
//
