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Database: UniProt
Entry: STAG3_RAT
LinkDB: STAG3_RAT
Original site: STAG3_RAT 
ID   STAG3_RAT               Reviewed;        1256 AA.
AC   Q99M76;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   07-JUN-2017, entry version 109.
DE   RecName: Full=Cohesin subunit SA-3;
DE   AltName: Full=SCC3 homolog 3;
DE   AltName: Full=Stromal antigen 3;
DE   AltName: Full=Stromalin-3;
GN   Name=Stag3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RX   PubMed=11599053; DOI=10.1002/mrd.1104;
RA   Bayes M., Prieto I., Noguchi J., Barbero J.L., Perez Jurado L.A.;
RT   "Evaluation of the Stag3 gene and the synaptonemal complex in a rat
RT   model (as/as) for male infertility.";
RL   Mol. Reprod. Dev. 60:414-417(2001).
CC   -!- FUNCTION: Meiosis specific component of cohesin complex. The
CC       cohesin complex is required for the cohesion of sister chromatids
CC       after DNA replication. The cohesin complex apparently forms a
CC       large proteinaceous ring within which sister chromatids can be
CC       trapped. At anaphase, the complex is cleaved and dissociates from
CC       chromatin, allowing sister chromatids to segregate. The meiosis-
CC       specific cohesin complex probably replaces mitosis specific
CC       cohesin complex when it dissociates from chromatin during prophase
CC       I. {ECO:0000250|UniProtKB:O70576}.
CC   -!- SUBUNIT: Component of the meiosis-specific cohesin complex, which
CC       also contains the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer. Such
CC       complex likely contains RAD21, or the meiosis-specific related
CC       protein REC8. Interacts with CCDC79/TERB1; recruiting cohesin to
CC       telomeres to develop structural rigidity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC       ProRule:PRU00750}. Chromosome {ECO:0000250}. Note=Associates with
CC       chromatin. In prophase I stage of meiosis, it is found along the
CC       axial elements of synaptonemal complexes. In late-pachytene-
CC       diplotene, the bulk of protein dissociates from the chromosome
CC       arms probably because of phosphorylation by PLK1, except at
CC       centromeres, where cohesin complexes remain. It however remains
CC       chromatin associated at the centromeres up to metaphase I. During
CC       anaphase I, it probably dissociates from centromeres, allowing
CC       chromosomes segregation (By similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Testis specific.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SCC3 family. {ECO:0000305}.
DR   EMBL; AY027880; AAK13052.1; -; mRNA.
DR   RefSeq; NP_446182.1; NM_053730.1.
DR   RefSeq; XP_006249082.1; XM_006249020.3.
DR   UniGene; Rn.18997; -.
DR   ProteinModelPortal; Q99M76; -.
DR   SMR; Q99M76; -.
DR   STRING; 10116.ENSRNOP00000041918; -.
DR   iPTMnet; Q99M76; -.
DR   PhosphoSitePlus; Q99M76; -.
DR   PaxDb; Q99M76; -.
DR   PRIDE; Q99M76; -.
DR   Ensembl; ENSRNOT00000042006; ENSRNOP00000041918; ENSRNOG00000001360.
DR   Ensembl; ENSRNOT00000092039; ENSRNOP00000072692; ENSRNOG00000001360.
DR   GeneID; 114522; -.
DR   KEGG; rno:114522; -.
DR   UCSC; RGD:621333; rat.
DR   CTD; 10734; -.
DR   RGD; 621333; Stag3.
DR   eggNOG; KOG2011; Eukaryota.
DR   eggNOG; COG5537; LUCA.
DR   GeneTree; ENSGT00390000014094; -.
DR   HOGENOM; HOG000231375; -.
DR   HOVERGEN; HBG057636; -.
DR   InParanoid; Q99M76; -.
DR   KO; K13055; -.
DR   OMA; GFPMDNL; -.
DR   OrthoDB; EOG091G0195; -.
DR   PhylomeDB; Q99M76; -.
DR   PRO; PR:Q99M76; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001360; -.
DR   Genevisible; Q99M76; RN.
DR   GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0034991; C:nuclear meiotic cohesin complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; TAS:RGD.
DR   GO; GO:0000795; C:synaptonemal complex; TAS:RGD.
DR   GO; GO:0000802; C:transverse filament; IEA:Ensembl.
DR   GO; GO:0051321; P:meiotic cell cycle; TAS:RGD.
DR   GO; GO:0034502; P:protein localization to chromosome; IEA:Ensembl.
DR   GO; GO:0007129; P:synapsis; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR020839; SCD.
DR   InterPro; IPR013721; STAG.
DR   Pfam; PF08514; STAG; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS51425; SCD; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Chromosome; Chromosome partition; Complete proteome;
KW   Meiosis; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN         1   1256       Cohesin subunit SA-3.
FT                                /FTId=PRO_0000120190.
FT   DOMAIN      324    409       SCD. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00750}.
FT   MOD_RES    1234   1234       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O70576}.
SQ   SEQUENCE   1256 AA;  141951 MW;  1C0B3F49D4B8B85D CRC64;
     MPTLWSPSTQ HHGSSSGSMS SPLRKSVRCA QMALSPCSSN IQPCDDRDSQ GTAEWDSSST
     SEDSDFEDSL RRNVRKRAAK RPPKAIPVAK HPKKQSHIVP GGNDKNKSVP PTSDLFDAVK
     AARSCAQSLV DEWLENYKQD ENAGFLELVN FFIRACGCKS TVTPEMFKTM SNSEIIQHLT
     EEFNEDSGDY PLTAPGPSWK KFQGSFCEFV KTLVCQCQYS LLFDGFPMDD LISLLIGLSD
     SQVRAFRHTS TLAAMKLMTS LVKVALQLSL HKDNNQRQYE AERNKGPEQR APERLESLLE
     KRKEFQENQE EIEGMMNAIF RGVFVHRYRD ILPEIRAVCI EEIGCWMQSY STSFLNDSYL
     KYIGWTLHDK HKEVRLKCVK ALAGLYSNQE LSSRMELFTN RFKDRMVSMV MDRESEVAVE
     AIRLLTLILK NMEGVLTSAD CEKIYSIVYI SNRAMASSAG EFVYWKIFHP ECGAKAVSGR
     ERRRSPQAQR TFIYLLLAFF MESEHHDHAA YLVDSLWDCA GSYLKDWESL TSLLLQKDQN
     LGDMQERMLI EILVSSARQA AEGHPPVGRI TGKKSLTAKE RKLQAYDKVK LAEHLIPLLP
     QLLAKFSADA ENVAPLLRLL SYFDLNIYCT QRLEKHLELL LQQLQEVVVK HVEPEVLEAA
     AHALYLLCKP EFTFFSRVDF ARSQLVDLLT DRFQQELDDL MQSSFLDEDE VYSLTATLKR
     LSAFYNAHDL TRWEISEPCS RLLRKAVDTG EVPHQVILPA LTLVYFSILW TVTHISESTS
     QKQLMSLKKR MVAFCELCQS CLSDVDPEIQ EQAFVLLSDL LLIFSPQMVV GGRDFLRPLV
     FFPEATLQSE LASFLMDHVF LQPGELGNGQ SQEDHVQIEL LHQRRRLLAG FCKLLLYGVL
     ELDAASDVFK HYNKFYEDYG DIIKETLTRA RQIDRCQCSR ILLLSLKQLY TELIQEQGPQ
     DLTELPAFIE MRDLARRFAL SFGPQQLHNR DLVVMLHKEG IKFSLSELPP AGSSREPPNI
     AFLELLSEFS PRLFHQDKQL LLSYLEKCLQ RVSMAPSHPW GPVTTYCHSL HLVENTAEAS
     SQGPPHSKKR CIEVPRRLQE EESSSQGESL QLNSGPTTPT LTSTAVKRRQ SPRTVGKRQK
     GGPGPGPGPG PGPGPGPGPG PGPGPGPELI CSQQLSGTQR LKMSSAPCFQ IRCDPSGSGL
     GKQMTRLSLM EEDEEEELRL LDEEWQCGDK LLHSPSSPSE HGLDLLDTTE LNMEDF
//
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