ID   STXB1_CHICK             Reviewed;         594 AA.
AC   Q6R748;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 93.
DE   RecName: Full=Syntaxin-binding protein 1;
DE   AltName: Full=N-Sec1;
DE   AltName: Full=Protein unc-18 homolog 1;
DE            Short=Unc18-1;
DE   AltName: Full=Protein unc-18 homolog A;
DE            Short=Unc-18A;
GN   Name=STXBP1; Synonyms=UNC18A;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Li Q., Khanna R., Stanley E.F.;
RT   "Complete coding sequence of chick nSec-1 (munc-18-1).";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the regulation of synaptic vesicle docking
CC       and fusion, possibly through interaction with GTP-binding proteins.
CC       Essential for neurotransmission and binds syntaxins, components of the
CC       synaptic vesicle fusion machinery. Involved in the release of
CC       neurotransmitters from neurons through interacting with SNARE complex
CC       component STX1A and mediating the assembly of the SNARE complex at
CC       synaptic membranes (By similarity). May play a role in determining the
CC       specificity of intracellular fusion reactions (By similarity).
CC       {ECO:0000250, ECO:0000250|UniProtKB:O08599}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P61764}. Membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR   EMBL; AY509605; AAR97943.1; -; mRNA.
DR   AlphaFoldDB; Q6R748; -.
DR   SMR; Q6R748; -.
DR   STRING; 9031.ENSGALP00000052373; -.
DR   PaxDb; 9031-ENSGALP00000011635; -.
DR   VEuPathDB; HostDB:geneid_404293; -.
DR   eggNOG; KOG1300; Eukaryota.
DR   InParanoid; Q6R748; -.
DR   PhylomeDB; Q6R748; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 1.25.40.60; -; 1.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679:SF35; SYNTAXIN-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR11679; VESICLE PROTEIN SORTING-ASSOCIATED; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; Sec1/munc18-like (SM) proteins; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..594
FT                   /note="Syntaxin-binding protein 1"
FT                   /id="PRO_0000291776"
SQ   SEQUENCE   594 AA;  67473 MW;  42E81B4DB5F09A06 CRC64;
     MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI MTEGITIVED
     INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTSKYR AAHVFFTDSC PDALFNELVK
     SRAAKVIKTL TEINIAFLPS ESQVYSLDSA DSFQSFYSPH KAQMKNPILE RLAEQIATLC
     ATLKEYPAVR YRGDYKDNAM LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPA
     SPVLHELTFQ AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWVS LRHKHIAEVS
     QEVTRSLKEF SSSKRMNTGD KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL AEDCMKHYQG
     TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDGNVS TYDKIRIILL YIFLKNGITE
     ENLNKLIQHA QIPAEDSEII TNMAHLGVPI ITDSTLRRRS KPERKERISE QTYQLSRWTP
     IIKDIMEDTI EDKLDTKHYP YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF
     ILGGVSLNEM RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS
//