ID SUB7C_COCP7 Reviewed; 400 AA.
AC C5NZ69;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Subtilisin-like protease CPC735_013700;
DE EC=3.4.21.-;
DE Flags: Precursor;
GN ORFNames=CPC735_013700;
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Secreted subtilisin-like serine protease with keratinolytic
CC activity that contributes to pathogenicity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR EMBL; ACFW01000001; EER30052.1; -; Genomic_DNA.
DR RefSeq; XP_003072197.1; XM_003072151.1.
DR AlphaFoldDB; C5NZ69; -.
DR SMR; C5NZ69; -.
DR GeneID; 9697692; -.
DR KEGG; cpw:CPC735_013700; -.
DR VEuPathDB; FungiDB:CPC735_013700; -.
DR HOGENOM; CLU_011263_1_3_1; -.
DR OrthoDB; 380531at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR43806:SF68; ALKALINE PROTEASE 1; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Hydrolase; Protease; Secreted; Serine protease; Signal;
KW Virulence; Zymogen.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..116
FT /evidence="ECO:0000250"
FT /id="PRO_0000407022"
FT CHAIN 117..400
FT /note="Subtilisin-like protease CPC735_013700"
FT /id="PRO_0000407023"
FT DOMAIN 36..115
FT /note="Inhibitor I9"
FT /evidence="ECO:0000255"
FT DOMAIN 126..400
FT /note="Peptidase S8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 161
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 192
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 346
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT CARBOHYD 252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 396
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 400 AA; 42830 MW; 8E1E56DC90BD0C7C CRC64;
MGFVKILSLS LAATAVADAA TILSPRYPND VIPNEYIVVM KDGVSSASFA SHSAWVADMH
YYNHTKRALP GHGIQEVYDI YEMKAYSGKF DEDTIQRIAK EPDVAFIEPN QIVTISEISV
QKAAPSWGLP RISVKENQLS SNTDYFYDSS AGAGIWVYVV DTGVDIKHPD FEGRAVWGTS
TVDRSKTDRL GHGTHVAGTI ASKTYGVAKA VKIIAVKVFK DRTTSYKNII GGIDWAVKHS
KKNNMLSKSV VNMSLGGGRS SAMNKAAANA HKTGMFVAVS AGNTPVDAMN FSPASEPLAC
TVAASDKDDM QAQFSAFGPA VDIFAPGTDI VSLVPRKKFG TKSGTSMAAA HVSGAGAYIM
ALEKIPGNEV CNRLKELAQS SIVRSSDKTT RKLLYNNSGK
//
