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Database: UniProt
Entry: T0C135_ALIAG
LinkDB: T0C135_ALIAG
Original site: T0C135_ALIAG 
ID   T0C135_ALIAG            Unreviewed;       461 AA.
AC   T0C135;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUL-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=N007_06615 {ECO:0000313|EMBL:EPZ46330.1};
OS   Alicyclobacillus acidoterrestris (strain ATCC 49025 / DSM 3922 / CIP
OS   106132 / NCIMB 13137 / GD3B).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Alicyclobacillaceae;
OC   Alicyclobacillus.
OX   NCBI_TaxID=1356854 {ECO:0000313|EMBL:EPZ46330.1, ECO:0000313|Proteomes:UP000015607};
RN   [1] {ECO:0000313|EMBL:EPZ46330.1, ECO:0000313|Proteomes:UP000015607}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49025 / DSM 3922 / CIP 106132 / NCIMB 13137 / GD3B
RC   {ECO:0000313|Proteomes:UP000015607};
RX   PubMed=24009113; DOI=10.1128/genomeA.00638-13;
RA   Shemesh M., Pasvolsky R., Sela N., Green S.J., Zakin V.;
RT   "Draft genome sequence of Alicyclobacillus acidoterrestris strain ATCC
RT   49025.";
RL   Genome Announc. 5:E00638-E00638(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EPZ46330.1}.
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DR   EMBL; AURB01000128; EPZ46330.1; -; Genomic_DNA.
DR   RefSeq; WP_021296360.1; NZ_AURB01000128.1.
DR   EnsemblBacteria; EPZ46330; EPZ46330; N007_06615.
DR   PATRIC; fig|1356854.4.peg.1722; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000015607; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000015607};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015607}.
FT   DOMAIN      155    283       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      367    436       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     163    170       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   461 AA;  52671 MW;  F48830959C05C213 CRC64;
     MSARTDTKYF DGLWSQVLAM MKERLSGPTF ETWFEGTKIL KYDAANHSLF VYTPTPFVKN
     WIEEHYTTTI QNMIIALTEQ EYRIQFVTDW SEEKQDTLPV RQPSRPELYA QPDTEEDQSQ
     GALISRYTFE TFVIGASNRF AHAACLAVAE RPAQGYNPLF IYGGVGLGKT HLMHAIGHYV
     KTHDPTAKIS YLSSEKFTNE FITAIRDSQT EAFRNKYRSI DVLLIDDIQF LAGKESTQEE
     FFHTFNSLHE AGKQIVISSD RPPREIPTLE DRLRSRFEWG LITDIQPPDL ETRIAILQRK
     ARSEGLEIPE EVLSYIANQI DSNIRELEGA LIRVVAYSSL VNEDVTPELA KAALKDIISP
     DRIRTITVSH VQKVIGDHFG LKIEDLKGKK RTRNIAFPRQ IAMYLTRELT EMSLPRIGEA
     FGGRDHTTVL HACERVNEEL QKDAELKATL ERLAQAIRTL T
//
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