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Database: UniProt
Entry: T0E483_HELPX
LinkDB: T0E483_HELPX
Original site: T0E483_HELPX 
ID   T0E483_HELPX            Unreviewed;      2805 AA.
AC   T0E483;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=N206_07700 {ECO:0000313|EMBL:EPZ73736.1};
OS   Helicobacter pylori UM111.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1352345 {ECO:0000313|EMBL:EPZ73736.1, ECO:0000313|Proteomes:UP000015461};
RN   [1] {ECO:0000313|EMBL:EPZ73736.1, ECO:0000313|Proteomes:UP000015461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UM111 {ECO:0000313|EMBL:EPZ73736.1,
RC   ECO:0000313|Proteomes:UP000015461};
RX   PubMed=24051312;
RA   Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA   Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA   Loke M.F., Vadivelu J.;
RT   "Multiple genome sequences of Helicobacter pylori strains of diverse
RT   disease and antibiotic resistance backgrounds from malaysia.";
RL   Genome Announc. 1:E00687-E00713(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPZ73736.1}.
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DR   EMBL; AUSR01000019; EPZ73736.1; -; Genomic_DNA.
DR   RefSeq; WP_021308984.1; NZ_AUSR01000019.1.
DR   PATRIC; fig|1352345.3.peg.969; -.
DR   Proteomes; UP000015461; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR41313:SF1; N6_MTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07669; Eco57I; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:EPZ73736.1};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000313|EMBL:EPZ73736.1};
KW   Hydrolase {ECO:0000313|EMBL:EPZ73736.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:EPZ73736.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1796..2048
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          2262..2455
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          445..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2768..2805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          703..730
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1296..1356
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1571..1598
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2480..2528
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2679..2713
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        450..497
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..544
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..607
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..651
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        652..668
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2768..2797
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2805 AA;  322931 MW;  98C81B5CAC9185C1 CRC64;
     MQKKKAKNPQ PNLFNILDNG DIATNIPSEE TDKVNETQES LPYVVKNQIN TARMISRNPI
     EWARYLSFEK RIYKDNSRED VNFFANGEIK ESSRVYEANK EGFERCITKR YDLIDTIKNR
     EFFSKEIDIL TYTNSLEELK SQGLEIELTS HYEVHRKTLE NGNEIVKEYD YLKDIYQEAE
     RTKDNELVRE IIPSISSAEY FKLYNKPPFE SLNNENTKLN TNGNEEVKKL EFELAKEVHV
     LILEQQLLSA TNYYSWIDKD DYASFAWKMH RLINENKLKE NHLSADNANK IKQFFFNNGF
     ILGWTKEEQS TMQENRDYSL RSALLSLEEI AQAKIELQKY YEIVYVNGDG SKRGIKPFKE
     ILRDINNFEK AYKERYNELV SLNEAIIQAK EGSNGQQNFS TNNNNTIKNT IETNTSIGNN
     IIQNNDNNNP NLSIADLGLE QQNLGEQNGK ERTNRADEPN RTRAGIPQEI HRRSEHGRQQ
     EGVERSSDEE LLHQDPSLFI EPREQGGTRG VYRSSDQQAV SEKSHRERDR LHEHVSRGDG
     VSAKAEARAD SNGASSQASR MENGARSEEK GDNPSDERGV SQTPQSPSHQ QNSSRDLGLS
     LSREQPRQTG RLRLFDHGQM GSLFPTDHEN QRESNDNELD RSSDRANENG DKSPRQNGSA
     NQESARSERY GIAQGSSNQS VLPLAQSRLH HAGLSAPNGL GNLEENRDQK RGLLSNLDHL
     ESLLNAIRNN TIASEPDFRS RLLEAIQNNE PLKDSLVGVQ LLKDPTTKIF YDKFQLKISP
     KKVLEILENR IKKSIETTNE TLNAFNTLDS QAIDGNAISN SVGLNPIQEN EIADNSVELN
     NTQEQTAQEQ DTQENAQTTI KQEAPTAPTI PLNPKIDFKP SEEVLIKGTK TRYKANIKAI
     ELLKELQAKQ EILKGDYYAT QEEQEILAQF SGWGGLESYF KKDQRPEEFK ELNALLTKDE
     FRRAYSSTRD AYYTPKLVID SIYQALDHLG FNNDNHQKEI FEPSLGTGKF IAHAPSDKNY
     RFIGTELDPI SANISKFLYP NQVIINTALE NHQFYQEYDA FVGNPPYGNH KIYSSNDKEL
     SNESVHNYFL GKAIKELKDD GIGAFVVSSW FMDGKNHKMR EHIAQNATFL GAIRLPNSVF
     KATGTEVSSD IVFFKKGVDE ATNQSFTKAM PYYDKIIDSL DDDTLFALQN NRFDSFIPSD
     QLKIVNAIAS HFGFKQEKLQ RWYEKIDTAN FGYKEQDYKI IKDFIDKVGE NNINLNEQTL
     NEYFIHHPEN ILGHLSLEKT RYSFEINGEQ IYKYELQALE DKSLDLSQAL NQAIEKLPKN
     VYQYHKTTLK TDALIIDANN KRYQEVQKLI KNLERGELVK WDNLYFQLEQ NNEMGVFLKP
     TKTNSKVQDS RLKAYFKIKD ALNDLTSAEF NPLSSDLELE SKRVRLNLVY DEFVKKFGYL
     NENKNRKDIK QDLYGAKVLG LEKDFEKEIT PRSAKMQNIE PRQAQAKKAQ IFFERTLNPK
     KELIITNAKE ALIASINQKG CLDLHFIRDH FTTQSLETTI KELLEQKLIY KDHKDNGDYV
     LANDYLSGNV KRKLKEVKEA INQGVEGLEA NVKDLELIIP KDLKATEIMA NINSPWIPTQ
     YLEEFLIELA ANHYEKQYGD KMTDYQLGNL KEDIKVEHLS GAYEVFARNN DLNELYGIRH
     KDKPHSYKAP FESLLNKVLN NKDLSVKYAQ VDPNDPKKEI FITDEEQSNL ARQKAEELKE
     AFKDWIYKDY ARRTHLEQIY NDTFNNSVLK TYDGSQLELE GFNHHISLRP HQKNAIFRTI
     QDRAVCLDHQ VGAGKTLCAI ASCMEQKRMG LVNKTLIAVP NHLTKQWGDE FYKAYPNANV
     LVVESKDITE KERELLFNQI ANNNYDAVII AHTHLELLSN PRGIIEELKE EELVNTEKNF
     ERQKLAYKNN PRETKKPNER AFKNKLDKIR AKYDAILEKQ GSHIDISQMG IDNLIVDEAH
     LFKNLAFETS MEKIAGLGNQ QGSNRARDLF IKTRYLHQNN KKIMFLTGTP IANSLSEMYH
     LQRYLTPDVL KERGLEFFDD WAKTYGEVVN DFELDTSAQS YKMVNRFSKF SDVQGLSTMY
     RAFADIVSND DILKHNPHFV PKVYGDKPIN VVVKRSEEVA QFIGVADENG KYNEGSIIDR
     MQKCEGKKSK KGQDNILSCT TDARKVALDY RLIDPNAKVE KEFSKSYAMA ENIYENYLET
     NATKGTQLGF IGLSTPKTHS QKVSLEAPDN AHEIENKNPL DEAQELLESL SSYDENGNLI
     APSKKELENE LKEKKAKSVN LDEEIAKSCS FDVYSDVLRH LVQMGIPQNE IAFIHDAKTE
     EQKQDLFKKL NRGEVRVLLG SPAKMGVGTN VQARLVAMHE LDCPWRPDEL LQMEGRGIRQ
     GNILHQNDPE NFRMKIYRYA TEKTYDSRMW QIIETKSKGI EQFRNAHKLG LNELEDFNMG
     SSNASEMKAE ATGNPLIIEE VKLRAEIKNE EAKYKAFNKE NYFNEENLKN NSSKLDYLKQ
     ELKDLETLQS SVMIPTHTEI KLYDLKKEES RDYELIKVKE VEPLKENASM SEELTHKKLK
     EQNKQIAEQN KEKLDAIKKQ FASNLNDLFF NEERDCKLLE YKGFVVNAYK TKYQVEFSLS
     PKYNPNVAYS PSNMVYKNDT ANMFSSYNFC GEIKFDGFLK RLDNAITKLP EKIKELENSL
     KITQENIAKY TRLVEQKPPY SRLEYLQALK WDHKTLIDDL AKMSKDRDYK PVFNPKSQEV
     LEKMNAGKRA SLENESLTEE IKEQANQEVH RPMKKVSSGD YDMGM
//
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