ID T0F8U5_9LEPT Unreviewed; 700 AA.
AC T0F8U5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Ammonium transporter {ECO:0000256|RuleBase:RU362002};
GN Name=amt_3 {ECO:0000313|EMBL:EQA43937.1};
GN ORFNames=LEP1GSC050_3566 {ECO:0000313|EMBL:EQA43937.1};
OS Leptospira broomii serovar Hurstbridge str. 5399.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049789 {ECO:0000313|EMBL:EQA43937.1, ECO:0000313|Proteomes:UP000015454};
RN [1] {ECO:0000313|EMBL:EQA43937.1, ECO:0000313|Proteomes:UP000015454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5399 {ECO:0000313|EMBL:EQA43937.1,
RC ECO:0000313|Proteomes:UP000015454};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC family. {ECO:0000256|ARBA:ARBA00005887, ECO:0000256|RuleBase:RU362002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQA43937.1}.
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DR EMBL; AHMO02000008; EQA43937.1; -; Genomic_DNA.
DR RefSeq; WP_010571681.1; NZ_AHMO02000008.1.
DR AlphaFoldDB; T0F8U5; -.
DR STRING; 1049789.LEP1GSC050_3566; -.
DR OrthoDB; 9814202at2; -.
DR Proteomes; UP000015454; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR001905; Ammonium_transpt.
DR InterPro; IPR018047; Ammonium_transpt_CS.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR NCBIfam; TIGR00836; amt; 1.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF6; AMMONIUM TRANSPORTER; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS01219; AMMONIUM_TRANSP; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Ammonia transport {ECO:0000256|ARBA:ARBA00023177,
KW ECO:0000256|RuleBase:RU362002}; Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362002}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 51..74
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 163..184
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 205..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 234..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 271..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 323..341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 353..379
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT DOMAIN 508..636
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 449..476
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 700 AA; 75884 MW; 3A02417CDC0E5333 CRC64;
MPTDKSLLDI LWILVCSGLV LIMQGGFLVL ESGLTRAKNS INVAIKNVAD FGVATLLFYS
FGFGLMFGTS WYGLFGTSQF FPEFPEGKAW GPTFFIFQLV FCGTAATIVS GAVAERLKFS
SYMLATALIS GIIYPIVNHW CWGGGGSLEE KNGWLSLLGF HDFAGSTLVH SVGGWVSLAL
LLVVGPRIGR FPKDGKPQQV TGSNLPMAML GGILLWFGWM GFNGGSTLSF NEKVPGIILN
TVVASGFSMM IAMLAAWLLK GFPEATAPLN GSLIGLVAIT AGADCLTPVQ SAIVGTIAGL
LIYPSEFLLE KLKIDDAVGA VPVHLIGGIW GTLATGIFGN LSIMQHETGR LSLLAIQSLG
ILLVGAFSFG VAYLAFWLLN RFYTLRVDGD EERMGLNISE HKATTELIDL FLAMDYQRKT
GDLAKDVPVE PFTEVGQIAE RYNLVLGKVR NTLAENEKAR QEILEAYEKV SFEQDRAEKL
LLNVLPPSIA AELKQNVGLI ADSHPNVSIL FADIVGFTQL SSSMKPESVV KLLNQIFSHF
DILAEKYRLE KIKTIGDAYM AVGGLPIPDK DHPLLVAHMA WDMKEILSRF KLKKLGTGLS
MRIGINTGPV VAGVIGTKKF IYDIWGDAVN VASRMESHGI AGEIQVTEST AQAIQSDFEL
AERGNIEVKG KGFVKAFIVS RRIRTPEQSL SHLNFSLGTN
//
