ID T0FGC1_9LEPT Unreviewed; 744 AA.
AC T0FGC1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:EQA46632.1};
GN ORFNames=LEP1GSC050_0292 {ECO:0000313|EMBL:EQA46632.1};
OS Leptospira broomii serovar Hurstbridge str. 5399.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049789 {ECO:0000313|EMBL:EQA46632.1, ECO:0000313|Proteomes:UP000015454};
RN [1] {ECO:0000313|EMBL:EQA46632.1, ECO:0000313|Proteomes:UP000015454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5399 {ECO:0000313|EMBL:EQA46632.1,
RC ECO:0000313|Proteomes:UP000015454};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQA46632.1}.
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DR EMBL; AHMO02000007; EQA46632.1; -; Genomic_DNA.
DR AlphaFoldDB; T0FGC1; -.
DR STRING; 1049789.LEP1GSC050_0292; -.
DR OrthoDB; 9806704at2; -.
DR Proteomes; UP000015454; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 477..617
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REPEAT 680..713
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 744 AA; 84589 MW; E919DBF2C51D5096 CRC64;
MSLKHKTDVQ ISIFSWFLSL SLIFCLPLIA EETVSSTHWK DIDLKRLDWY SLEGFLPEYK
NGFDENTNEV RKIESFPVVL NAIYDSAISS GTKEFTLQTR FVLQEDPKQY YFIEPISLFI
NSIGENWEIF LNGHLLKSEV HLALDGQIER RRTIRQLRLP LDSSLLKQGS NILVFRLIGD
APAVALPELL APRNPDLGFY VDGEYSINKN LDFTREAGVL LNLSLNTIYV FFGLYHLLIF
SKRTADKYNL YFGVFSIAMA VYSLCRSSLS FEVIADTAVI TRVEYGSVAL LASLFLLFLH
DYFYGRALPN LPILIIAGWS FVIFFFSLLA PFRFLMTSLR LWQFSMVPTL IYLLYFIGKA
VYLRKKDASL MAISMFVIVF IAIYDILDSV FFQLGIRFTQ FAYLLFVISL TTILANRFIE
LYKQSEDLNI ELSHQKLELA RQKNAFFRFV PMQFLSVLGK DSAVDVNLGD SALREMSVLF
TDIRSFTTIS EKMTPEENFR FINGYLASME PLIQKYDGFV DKFMGDAILA LFSAERAVQS
PDQWEGKSAA DRAVYAAIAM KKRIRELDVE VKGGHLKGVR IGIGINTGNL MLGTVGSSDR
LDTTVIGDTV NVASRLESLT SLYKADILIT QQTLASLTIS DDVAIREVDS VVVKGKSQPI
IIYEVYEADD PHIRKLKEAT LPLVSRGIIL YKVGNFKDAL VNFEQALKVF PEDIVAILYR
KRCQEYIETP PLGNWVGVQH LLEK
//
