ID T0FVX0_9LEPT Unreviewed; 690 AA.
AC T0FVX0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=7TM diverse intracellular signaling {ECO:0000313|EMBL:EQA81780.1};
GN ORFNames=LEP1GSC193_0260 {ECO:0000313|EMBL:EQA81780.1};
OS Leptospira alstonii serovar Pingchang str. 80-412.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1218564 {ECO:0000313|EMBL:EQA81780.1, ECO:0000313|Proteomes:UP000015445};
RN [1] {ECO:0000313|EMBL:EQA81780.1, ECO:0000313|Proteomes:UP000015445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=80-412 {ECO:0000313|EMBL:EQA81780.1,
RC ECO:0000313|Proteomes:UP000015445};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Galloway R.L., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQA81780.1}.
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DR EMBL; AOHD02000017; EQA81780.1; -; Genomic_DNA.
DR RefSeq; WP_020775212.1; NZ_AOHD02000017.1.
DR AlphaFoldDB; T0FVX0; -.
DR STRING; 28452.A0128_08240; -.
DR Proteomes; UP000015445; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 2.60.40.2380; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR011622; 7TMR_DISM_rcpt_extracell_dom2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF07696; 7TMR-DISMED2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 185..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 449..575
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REPEAT 638..671
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 379..411
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 690 AA; 79069 MW; 2B0C932E7240BF47 CRC64;
MGFIIRSALV YSIFLISSSL FSQSLIVDSN FKKSNLIGYV ERYEDNQTSL KLADLDKKEF
SFQKVNKVNL GYSDSAHWLR FGLKNPDRSS KLIIYELAYP LIDSIEVYIK NLDSGEIATL
RSGDKLPFKT REIRHQNFTF PIRLAAQTEY RLMVRILTES SVQFPMTLWS ANEFSNHVVD
EQKTFGLYYG IMIAMMAYNF FLFIGTRDKS YLFYVLFLTG YVLFQACLNG LAFQYLWPDA
IWWANSSLPF FMFFGGGWGA QFSREFLRMK SYHPLLDKIL LSYFVLGMIA SVLSLGLNFS
IGIKLAIAYV FLMVVLLIAA GLVSIFKGYR AARFYLSAWI FLLLGIVTYI LKTLTLFPSN
FVTEYSIQFG SSFEVLLLSL ALADRINILK KEKEEAQKKL IENQKEALKR QTVMTQSFER
FVPKQFLNHL GKEDISDIRL GDQARKEMTI FFSDIRHFTK LSEKMDPKDN FNFLNSYLKR
MNPLVIQNGG FVDKFIGDAI MALFPESGED ALRAAIEMQS EVRLYNHHRL KIGYEPIKIG
IGIHTGHLML GTIGTEERME GTVISDTVNL ASRIEGLTKK FDSSILISEK TLQTIPDPTR
YKMRLIGRAK VKGKEDEIVI FDVYEGLSQF QIDLRNGTKY DFEKGVTNFL LKEFDRAQDA
FASVLKVDPT DIAAEAYLKA LRKTSALRKG
//