ID   T0GZG7_9LEPT            Unreviewed;       750 AA.
AC   T0GZG7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:EQA72711.1};
GN   ORFNames=LEP1GSC059_2463 {ECO:0000313|EMBL:EQA72711.1};
OS   Leptospira noguchii serovar Panama str. CZ214.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1001595 {ECO:0000313|EMBL:EQA72711.1, ECO:0000313|Proteomes:UP000015442};
RN   [1] {ECO:0000313|EMBL:EQA72711.1, ECO:0000313|Proteomes:UP000015442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CZ214 {ECO:0000313|EMBL:EQA72711.1,
RC   ECO:0000313|Proteomes:UP000015442};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA   van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA   Fouts D.E.;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQA72711.1}.
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DR   EMBL; AKWY02000014; EQA72711.1; -; Genomic_DNA.
DR   RefSeq; WP_002177815.1; NZ_AKWY02000014.1.
DR   AlphaFoldDB; T0GZG7; -.
DR   GeneID; 23201045; -.
DR   Proteomes; UP000015442; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        171..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        436..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          455..507
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          539..671
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   750 AA;  85349 MW;  EF8931B6FEA84D6C CRC64;
     MTEQKTFLFC SRLKEGGMLD RWKNKNDKSV RWEELPNLHS DLQDLDLIIR SLISEKLSLG
     IREIVFCLSA EQALSLKKSR NFLKLIKDLK RAGFTISSAD RDKILSANVE SSSKFFRYLE
     NRSRNTNCLV WTEISELSQI ESKYYDFLNH FRQINGDQSF RPSRFTIRVK LLSIVSAIIT
     LSMGLMITMA TYFFRKYSEI LIQEYNLSLA RMTGLQLSGQ LKETTRKIQD FRSEDSEKFF
     KTNSNAVAYV RFKSKAVNSV WEIDSLFWNS KFLKSNSVVL DSTHLKKALE KSFSRLSNTL
     EILNVSSEFG FPAVAVLLPI DDKICGLVFS ASEFLGSFLS VRQTDFFQMI VVDSSGNLIA
     HSNDKEAVSG KDYKKHPLVE NMLRSPSDNG SQRFDFEGRE VLGSYQQLEV GGLGIISTLD
     ADIAFEAVYQ IRRQNLWIMI SVLSVAFFVV FVFSRTLTIP IIQLLSATKK VEQGDYVVDI
     RATTHDEVGV LTNSFLRMAR GLEEREKIKN TFGKFVNKEI AERALSSDLK LGGENREVTV
     FFSDLRNFTG MSEKMKPEEV VEFLNQYFTE MVECIYLTQG IVDKFIGDAV MAHWGALVHD
     GNEAKNSINA ALLMRRALIE FNLKGKEIGR PFTRFGCGIN SGPVIVGQIG SEKKLEFTVI
     GDAVNLASRI EYLNKEFGTD ILISESTYQQ TKDHFNFVEL PPVWIRGKEK PQVIYAVLGW
     KEDQDCPKSL EELRTLCDIP DPENPSRSLA
//