ID T0HZU2_9FIRM Unreviewed; 497 AA.
AC T0HZU2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=UNSWDHB_461 {ECO:0000313|EMBL:EQB22245.1};
OS Dehalobacter sp. UNSWDHB.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Dehalobacter.
OX NCBI_TaxID=1339256 {ECO:0000313|EMBL:EQB22245.1, ECO:0000313|Proteomes:UP000015814};
RN [1] {ECO:0000313|EMBL:EQB22245.1, ECO:0000313|Proteomes:UP000015814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNSWDHB {ECO:0000313|EMBL:EQB22245.1,
RC ECO:0000313|Proteomes:UP000015814};
RX PubMed=24051315;
RA Deshpande N.P., Wong Y.K., Manefield M., Wilkins M.R., Lee M.;
RT "Genome Sequence of Dehalobacter UNSWDHB, a Chloroform-Dechlorinating
RT Bacterium.";
RL Genome Announc. 1:e00720-13(2013).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB22245.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AUUR01000052; EQB22245.1; -; Genomic_DNA.
DR RefSeq; WP_021315305.1; NZ_AUUR01000052.1.
DR AlphaFoldDB; T0HZU2; -.
DR PATRIC; fig|1339256.3.peg.635; -.
DR Proteomes; UP000015814; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR025274; DUF4070.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034530; HpnP-like.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF3; HYPOTHETICAL METHYLTRANSFERASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13282; DUF4070; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00303; hopanoid_C2-methyltransferase; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 159..409
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 497 AA; 57245 MW; F58398A137F216D3 CRC64;
MKILLVYPQI PLTYWSFQYA LKFISKKAGS PPLGLLSVAA MLPEHYDKRL VDMNVTKLKD
RDILWADYVW ISAMVVQKES VREVINRCHA LGVKTTAGGP LFTSEPEEYD DVDYLVLNEG
ENTVPAFVRD LENGSAAHIY TTEEWADIRN TPVPLWDLID MKHYATMNIQ YSRGCPFHCD
FCNITSLYGH EPRTKTSPQL LSELDSLYRA GWRGGIFLVD DNFIGNKKKL MDDILPALIS
WMKQRNYPFS FITEASINLA DDDSLMNLMV KAGFMTVFIG IETMDEDSLV ECNKIQNKNR
NLIACIKKIQ KFGLQVQGGF IVGFDNDNAS IFDKLVTFIQ ESGIVTAMVG LLNAPKGTKL
YQRLAVEGRL LKSISGDNTD FSMNFIPKME SRQLIKGYQR IVDTIYSPRK YYERVLTFLE
QYEPAGFTAQ RIDRCQALAF IRSVFRLGII GQERRYYWKL IIWSLRKRRN VFPLAVTLSI
YGFHFRKVFR RTEEILK
//
