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Database: UniProt
Entry: T0K2K4_9SPHN
LinkDB: T0K2K4_9SPHN
Original site: T0K2K4_9SPHN 
ID   T0K2K4_9SPHN            Unreviewed;       500 AA.
AC   T0K2K4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   25-OCT-2017, entry version 28.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=M529_17730 {ECO:0000313|EMBL:EQB30794.1};
OS   Sphingobium ummariense RL-3.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=1346791 {ECO:0000313|EMBL:EQB30794.1, ECO:0000313|Proteomes:UP000015523};
RN   [1] {ECO:0000313|EMBL:EQB30794.1, ECO:0000313|Proteomes:UP000015523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RL-3 {ECO:0000313|EMBL:EQB30794.1,
RC   ECO:0000313|Proteomes:UP000015523};
RX   PubMed=24233594;
RA   Kohli P., Dua A., Sangwan N., Oldach P., Khurana J.P., Lal R.;
RT   "Draft Genome Sequence of Sphingobium ummariense Strain RL-3, a
RT   Hexachlorocyclohexane-Degrading Bacterium.";
RL   Genome Announc. 1:e00956-13(2013).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EQB30794.1}.
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DR   EMBL; AUWY01000116; EQB30794.1; -; Genomic_DNA.
DR   EnsemblBacteria; EQB30794; EQB30794; M529_17730.
DR   PATRIC; fig|1346791.3.peg.3417; -.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000015523; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015523};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015523}.
FT   DOMAIN       31    124       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      147    462       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   500 AA;  54031 MW;  2CBDC8F2C06165F0 CRC64;
     MTPMSPEYDA EFDGSGRLLA EERAGDNAPP LSVSELSARL KRTVEDRFGH VRLRGEISGF
     KRAASGHLYL CLKDDNAVID GVMWKGGAAR LAFAAQDGVE VIATGKLTTY PGRSKYQIVI
     DRMELAGEGA LMALLEKLKA KLAAEGLFDP ARKRRLPFLP RTIGVVTSPT GAVIRDILHR
     LADRCPTNVL LWPVLVQGEG AAAQVARAVR GFSAMPADGP LPRPDLVIVA RGGGSIEDLW
     SFNEEIVVRA VAECTIPTIS AVGHETDTTL CDHAADMRAP TPTAAAEMAV PVRAELVAML
     KEQGLRMDRS VRRGAAQARE RLEMQARLMP TPDTLLAPQR QRLDQLSDAL AGGLRHRVAE
     ARAHLGQAGG ALRPALLRQA LGRARERVER LQLRPDYLAR VHADRATAFD RLSRLFVSLD
     PDRPLQRGFA RVMAGEHVVK GVADARAAGQ VVLHFRDGAV GATVEGAPLE PDGPTGLSSP
     QRPARKPRGE GETRQQDLFS
//
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