ID T0LPH0_COLGC Unreviewed; 761 AA.
AC T0LPH0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
GN ORFNames=CGLO_06642 {ECO:0000313|EMBL:EQB53611.1};
OS Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus)
OS (Glomerella cingulata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1237896 {ECO:0000313|EMBL:EQB53611.1, ECO:0000313|Proteomes:UP000015530};
RN [1] {ECO:0000313|Proteomes:UP000015530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cg-14 {ECO:0000313|Proteomes:UP000015530};
RX PubMed=23902260; DOI=10.1094/MPMI-03-13-0080-R;
RA Alkan N., Meng X., Friedlander G., Reuveni E., Sukno S., Sherman A.,
RA Thon M., Fluhr R., Prusky D.;
RT "Global aspects of pacC regulation of pathogenicity genes in Colletotrichum
RT gloeosporioides as revealed by transcriptome analysis.";
RL Mol. Plant Microbe Interact. 26:1345-1358(2013).
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920,
CC ECO:0000256|PIRNR:PIRNR028937};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|PIRNR:PIRNR028937}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB53611.1}.
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DR EMBL; AMYD01001339; EQB53611.1; -; Genomic_DNA.
DR AlphaFoldDB; T0LPH0; -.
DR STRING; 1237896.T0LPH0; -.
DR eggNOG; ENOG502QSD8; Eukaryota.
DR HOGENOM; CLU_008878_3_1_1; -.
DR OMA; CFQGCKW; -.
DR OrthoDB; 601859at2759; -.
DR Proteomes; UP000015530; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF4; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 3.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR028937};
KW Reference proteome {ECO:0000313|Proteomes:UP000015530};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 217..249
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 266..495
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 587..746
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT REGION 637..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 694
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
SQ SEQUENCE 761 AA; 82873 MW; C9025E79BB8DEC8C CRC64;
MGLPEEVSKV ELPVLPTSDF WNETQWSVLF SLLEAALPSI ARPATLSDKT NQVRVSEAEY
AQALQLVQNT MKNPPSEEKF QEYLAHCPAK EPKFVESVTR TLAALPSAAQ KTLGGAMGAL
GTRTGTWFLT GYWTPANQQP LYVRERMLKA WQTSRVPTIR VLSKSLCLLA QKCAVQTSPL
FRELTDYTDM PDFQTHGEGF DFKFMQFESS ASPAIVETDV VIVGSGCGGA VAAKVLSEAG
HKVLVVDKSY YFPPSQLPMT QDTGCQYLYE NGGFITSDDN CLNMVAGSCW GGGGTVNWSV
SLQTQGFVRK EWSEQRGLPF FTSPQFQNSL DKVCEFMGVS ADKIKHNHRN KVLLDGSRKL
GWHAATAPQN TGGAEHYCGQ CHLGCGSTEK QGPTVSWLPA AAASGAKFIE GFEVEKVTFD
ESTGSKRATG VVGKWISRDA NGNVSTPVEQ RTTRQVIIKA KKVIMSAGSV SSPLVLLRSG
LTNRHIGRNL YVHPCNFVGG YWKEDAKPWE GGIITSYCST FEDLDKAGHG VKLEPTCMIP
YAILSSMPWQ SGLAAKMAEL RFRHFGAFIS LTRDRDPGRV YPDPITGRPR IDYVVSDFDR
ANTLEGVIAL AKICYVEGAS EIHAFFPGLA PFVKEDHAEP PEKSMADLSS SSHENGLEHD
GTLDGVNDPK FNAWLEEVRK VGNAPPVAIF SSAHQMGTCR MAPNEDEGVV GPKGHVWGTE
NLFVADASVF PSASGVNPMI TNMAIADWIA AGIAKELKTE A
//
