ID T0M3Q8_CAMFR Unreviewed; 634 AA.
AC T0M3Q8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-2 {ECO:0000256|ARBA:ARBA00041202};
DE AltName: Full=Sodium/potassium-dependent ATPase subunit beta-2 {ECO:0000256|ARBA:ARBA00041458};
GN ORFNames=CB1_000230033 {ECO:0000313|EMBL:EQB77174.1};
OS Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=419612 {ECO:0000313|EMBL:EQB77174.1, ECO:0000313|Proteomes:UP000030684};
RN [1] {ECO:0000313|EMBL:EQB77174.1, ECO:0000313|Proteomes:UP000030684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX PubMed=23149746;
RG Bactrian Camels Genome Sequencing and Analysis Consortium;
RA Jirimutu, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H., Wang L.,
RA Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S., Zhang W.,
RA Batmunkh M., Ts B., Narenbatu, Unierhu, Bat-Ireedui S., Gao H.,
RA Baysgalan B., Li Q., Jia Z., Turigenbayila, Subudenggerile, Narenmanduhu,
RA Wang Z., Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt, Erdemt, Altansha,
RA Altansukh, Liu T., Cao M., Aruuntsever, Bayart, Hosblig, He F., Zha-ti A.,
RA Zheng G., Qiu F., Sun Z., Zhao L., Zhao W., Liu B., Li C., Chen Y.,
RA Tang X., Guo C., Liu W., Ming L., Temuulen, Cui A., Li Y., Gao J., Li J.,
RA Wurentaodi, Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T.,
RA Bayaer T., Li Y., Meng H.;
RT "Genome sequences of wild and domestic bactrian camels.";
RL Nat. Commun. 3:1202-1202(2012).
CC -!- FUNCTION: Mediates cell adhesion of neurons and astrocytes, and
CC promotes neurite outgrowth. {ECO:0000256|ARBA:ARBA00037754}.
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane. The exact function of
CC the beta-2 subunit is not known. {ECO:0000256|ARBA:ARBA00037574}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000256|ARBA:ARBA00005876}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR EMBL; KB016523; EQB77174.1; -; Genomic_DNA.
DR AlphaFoldDB; T0M3Q8; -.
DR Proteomes; UP000030684; Unassembled WGS sequence.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR PANTHER; PTHR11523:SF26; SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF00287; Na_K-ATPase; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00391; ATPASE_NA_K_BETA_2; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..634
FT /note="Sodium/potassium-transporting ATPase subunit beta-2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004567750"
FT TRANSMEM 383..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..293
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 27..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 71372 MW; C11E573B8A5E5BFC CRC64;
MESRGPLATW HGLLLLLPLM PPSHAGRALR HTVPSQRTQD PPALHLSNGP GQEPVTIMTF
NLTKITKTSS SYEFRTWDPE GVIFYGDTNP KDDWFVLGLW GGRPEVQLHN HWAQLTVVIG
PWLDDGRWHQ LEVKIHRDSV LLGWMGRRCC LRLRQVSGPL AYKPQPIMRI AVGRLLFPAS
NLWLPLNLTV SRVVLSQGPK KEMLTLPPVG PGSLFNLWAQ LQGHLFLGAL PGISQDLNGS
RTLPGPTKGT YDACPVSCAS PTPLKPFQSL APYAAAFRPA YNDSIQAQKN DVCRPGRYYE
QPDNGVLNYP KRACQFNRTQ LGDCSGIGDP THYGYSTGQP CVFIKMNRVI NFYAGANQSM
NVTCMGKRPH HHRDKGVRVD STFILLFYLV FYGFLTAMFT LTMWVMLQTV SDHTPKYQDR
LATPGLMIRP KTENLDVIVN VSDTESWDQH VQKLNKFLEP YNDSIQAQKN DVCRPGRYYE
QPDNGVLNYP KRACQFNRTQ LGDCSGIGDP THYGYSTGQP CVFIKMNRVI NFYAGANQSM
NVTCMGKRDE DAENLGSFVM FPANGNIDLM YFPYYGKKFH VNYTQPLVAV KFLNVTPNVE
VNVECRINAA NIATDDERDK FAGRVAFKLR INKT
//
