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Database: UniProt
Entry: T0MFC7_9MICR
LinkDB: T0MFC7_9MICR
Original site: T0MFC7_9MICR 
ID   T0MFC7_9MICR            Unreviewed;       515 AA.
AC   T0MFC7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-OCT-2016, entry version 10.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=NAPIS_ORF02674 {ECO:0000313|EMBL:EQB59780.1};
OS   Nosema apis BRL 01.
OC   Eukaryota; Fungi; Microsporidia; Nosematidae; Nosema.
OX   NCBI_TaxID=1037528 {ECO:0000313|EMBL:EQB59780.1, ECO:0000313|Proteomes:UP000053780};
RN   [1] {ECO:0000313|EMBL:EQB59780.1, ECO:0000313|Proteomes:UP000053780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL 01 {ECO:0000313|EMBL:EQB59780.1,
RC   ECO:0000313|Proteomes:UP000053780};
RX   PubMed=23829473; DOI=10.1186/1471-2164-14-451;
RA   Chen Yp., Pettis J.S., Zhao Y., Liu X., Tallon L.J., Sadzewicz L.D.,
RA   Li R., Zheng H., Huang S., Zhang X., Hamilton M.C., Pernal S.F.,
RA   Melathopoulos A.P., Yan X., Evans J.D.;
RT   "Genome sequencing and comparative genomics of honey bee
RT   microsporidia, Nosema apis reveal novel insights into host-parasite
RT   interactions.";
RL   BMC Genomics 14:451-451(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KE647366; EQB59780.1; -; Genomic_DNA.
DR   EnsemblFungi; EQB59780; EQB59780; NAPIS_ORF02674.
DR   Proteomes; UP000053780; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053780};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053780};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    158    189       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    210    227       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    276    298       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    305    329       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    366    392       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    413    434       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    475       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   515 AA;  59384 MW;  057B7A1026F541E9 CRC64;
     MKKIFVSLGG RVLDIEKYND PQKNSLALTS VISQIDCVEK HNDEAMKNEI QKISSLYLTW
     KYYIEKEYKI YKSLNKFNFD KDRDLLVGDA WVRTDDLNRL KRMSESSENS DWNFAFEKIE
     ICEDVPPSSF KLCKYVETFQ DLVNVYGLPS YGEINPGIFM IFLFPMLFGV MFGDVFHGTL
     LVLISMYFIK HAKKLKKKFK SIEMLIDGRY VMFLCGLCSI LFGFLYSDFS AFSINLFGSR
     IANRTNDFDI YPFGIDPAWH EAANNMEFTN SVKMKLSLVI GFLHMGLGIC ISIFNCLYFK
     NTVDLLCVVI PQAIAYVAFF GYLIFLILFK WLTIDLNVRN PSLISTYVLM FTSPFEIKDQ
     IYPGQMFVQL ILLCLIFLSF PWMLLVKPIY LIKKNRVKNK EYTDLWMNQG IHMVEFGIGL
     ISNSSSYLRL WAVSLAHAQL TKVLVENTIK QDSILLQAAL LPLFIAGTLT LLIGLEGLGA
     CLHSLRLNWI EFNSKFYGGT GYKFEPLSFK EINED
//
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