ID T0N875_9CLOT Unreviewed; 731 AA.
AC T0N875;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Penicillin-binding protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M918_06230 {ECO:0000313|EMBL:EQB87986.1};
OS Clostridium sp. BL8.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1354301 {ECO:0000313|EMBL:EQB87986.1, ECO:0000313|Proteomes:UP000015873};
RN [1] {ECO:0000313|EMBL:EQB87986.1, ECO:0000313|Proteomes:UP000015873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BL8 {ECO:0000313|EMBL:EQB87986.1,
RC ECO:0000313|Proteomes:UP000015873};
RX PubMed=25076986; DOI=10.1186/1757-4749-6-30;
RA Marathe N.P., Shetty S.A., Lanjekar V.B., Rasane M.H., Ranade D.R.,
RA Shouche Y.S.;
RT "Genome sequencing of multidrug resistant novel Clostridium sp. BL8 reveals
RT its potential for pathogenicity.";
RL Gut Pathog. 6:30-30(2014).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB87986.1}.
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DR EMBL; AUPA01000177; EQB87986.1; -; Genomic_DNA.
DR AlphaFoldDB; T0N875; -.
DR STRING; 1354301.M918_06230; -.
DR PATRIC; fig|1354301.3.peg.2414; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000015873; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR007887; MecA_N.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627:SF25; PENICILLIN-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR Pfam; PF05223; MecA_N; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000015873}.
FT DOMAIN 78..200
FT /note="NTF2-like N-terminal transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF05223"
FT DOMAIN 209..368
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 410..724
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 731 AA; 81253 MW; 74A92631EAB8D446 CRC64;
MDKPLRRLFK KCSIMAFIKA KSSKDNTVPY RKSFTKTPKD NINKETNFIA SRKYKSLAIA
TSILVILALL TACNKKENPH DIFETYKENW QKQDFKAMYN MVSNNTKTSI SEEDFVKRYS
NIYDGIEAKD ISITVGSTED LKQTKEDNVK IPFSINMNTL AGNIEVPGYE VTMTKEKQDK
KSTWKILWNE RLIFPYMEPG DRVRAEVFTP TRGEIYDRSG KGLAINAKIN SVGIHPRFFE
EDKENKIIQM SKVLDIKPEV IQDKLKRNSN PDFFVPIVKM SLSEKERKDY VLQIKGVRVN
EEMGRVYPGG EATGALIGYV GPITAEELEK VKNQGYGGNS FIGKKGLEQV YEKRLKGESG
GRIYIERGSE DKKEVIEVAK KEPKDGENIK VSIDSELQKK IYEEMNKEPG AAVAAHPKTG
EVLAMVSSPS YDPNLFSTYI SEGQRAAWEA TPVDEFDNKF NNSYSPGSTF KLITAAVGLN
KGAIKPEEAV GIEGNQWQPS KSWGSYNITR VKDPGKPVTL RDAFKYSDNI YFAMASLKIG
KEEFVKGAMS FGIGEEIPFD YPTENTQVAN GNKIAKDVLL ADSGYGQGEV LVTPLHLALA
YSSLVNEGNV IAPALDITNG YTAKVWKSKS IGGENIAPLI EGLKAVVEDP EGTAHEGKIN
GVTIGGKTGT AELKKDAQDT EGKENGWFVA LNLDDPKIVV SMVIEDVKAK GGSHFVVPKV
KNVIEYYLKR G
//
