GenomeNet

Database: UniProt
Entry: T0NJY4_CAMFR
LinkDB: T0NJY4_CAMFR
Original site: T0NJY4_CAMFR 
ID   T0NJY4_CAMFR            Unreviewed;      1586 AA.
AC   T0NJY4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   10-MAY-2017, entry version 25.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=CB1_000497003 {ECO:0000313|EMBL:EQB77873.1};
OS   Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda;
OC   Camelidae; Camelus.
OX   NCBI_TaxID=419612 {ECO:0000313|EMBL:EQB77873.1, ECO:0000313|Proteomes:UP000030684};
RN   [1] {ECO:0000313|EMBL:EQB77873.1, ECO:0000313|Proteomes:UP000030684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bactrian camel {ECO:0000313|Proteomes:UP000030684};
RX   PubMed=23149746;
RG   Bactrian Camels Genome Sequencing and Analysis Consortium;
RA   Jirimutu null, Wang Z., Ding G., Chen G., Sun Y., Sun Z., Zhang H.,
RA   Wang L., Hasi S., Zhang Y., Li J., Shi Y., Xu Z., He C., Yu S., Li S.,
RA   Zhang W., Batmunkh M., Ts B., Narenbatu null, Unierhu null,
RA   Bat-Ireedui S., Gao H., Baysgalan B., Li Q., Jia Z.,
RA   Turigenbayila null, Subudenggerile null, Narenmanduhu null, Wang Z.,
RA   Wang J., Pan L., Chen Y., Ganerdene Y., Dabxilt null, Erdemt null,
RA   Altansha null, Altansukh null, Liu T., Cao M., Aruuntsever null,
RA   Bayart null, Hosblig null, He F., Zha-ti A., Zheng G., Qiu F., Sun Z.,
RA   Zhao L., Zhao W., Liu B., Li C., Chen Y., Tang X., Guo C., Liu W.,
RA   Ming L., Temuulen null, Cui A., Li Y., Gao J., Li J., Wurentaodi null,
RA   Niu S., Sun T., Zhai Z., Zhang M., Chen C., Baldan T., Bayaer T.,
RA   Li Y., Meng H.;
RT   "Genome sequences of wild and domestic bactrian camels.";
RL   Nat. Commun. 3:1202-1202(2012).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB016781; EQB77873.1; -; Genomic_DNA.
DR   Proteomes; UP000030684; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF235; PTHR10037:SF235; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030684};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EQB77873.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030684};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    166    186       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    295    322       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    652    677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    739    762       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    984   1002       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1023   1045       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1051   1071       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1109   1132       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1144   1162       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1169   1194       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1231   1259       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1335   1358       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      124    328       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      401    575       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      574    767       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      776    978       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      982   1101       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1113   1368       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      330    353       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1586 AA;  179682 MW;  C5DCE29646D24F41 CRC64;
     MAMLPPPGPQ SFVYFTKQSL ALIEQRIAEG KTKEPKEEKK DDDEEGPKPS SDLEAGKQLP
     FIYGDIPPGM VSEPLEDLDP YYADKKVFNR ICKPRQCFSS SNFQSVESFE NYFCNPRYVT
     EFVDLGNVSA LRTFRVLRAL KTISVIPGLK TIVGALIQSV KKLSDVMILT VFCLSVFALI
     GLQLFMGNLK HKCVWTPFEN NETIESMLDS LDEEDRSKYF YYLEGSKDAL LCGFSTDSGQ
     CPEGYTCMKI GRNPDYGYTS FDTFSWAFLA LFRLMTQDYW ENLYQQTLRA AGKTYMIFFV
     VVIFLGSFYL INLILAVVAM AYEEQNQANI EEARQKEIEF QQMLDHLKKE QEEAEAIAMA
     AAEYTSIGRS RIMGLSESSS ETSRLSSKSA KERRNRRKKR NQKKLSSGEE KGDDEKFSKS
     ESEENIRRKS FRLGVEGPRR AHEKRLSTPN QSPLSIRGSL FSARRSSRTS LFSFKGRGKD
     IGSETEFADD EHSIFGDSES RRGSLFVPHR PRERRSSSIS QASRSPPVLP VNGKMHSAVD
     CNGVVSLVDG PAALMLPNGQ LLPEVIIDKA TSDDSVFTGI FAAEMVLKLI AMDPYEYFQV
     GWNIFDSLIV TLSLVELFLA DVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL
     GNLTLVLAII VFIFAVVGMQ LFGKSYKECV CKISEECTLP RWHMNDFFHS FLIVFRVLCG
     EWIETMWDCM EVAGQAMCLI VYMMVMVIGN LVVLNLFLAL LLSSFSSDNL TAIEEDTDAN
     NLQIAVARIK KGINYVKQTL REFILKAFSK KPKVSKEIRR ADLNCKKENF ISNRTLAEMS
     KDHHFHKEKD KTSGFGNSVD KYLMEESDGQ SFIHNPSLTV TVPIAPGESD LEIMNTEELS
     SDSDSEYSKG RLNRSSSSEC STVDNALPEK EAEAEPVNPD EPAACFTDGC VRRFPCCQVN
     IESGKGRIWW NIRKTCYRIV EHSWFESFIV LMILLSSGAL AFEDIYIEKK RTIKTILEYA
     DKIFTYIFIL EMLLKWVAYG YKIYFTNAWC WLDFLIVDVS LVTLVAAAFG YSDLGPIRSL
     RTLRALRPLR ALSRFEGMRN KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQSEY
     MTEVLYWINV VFIILFTGEF VLKLISLRCY YFTVGWNIFD FVVVILSIVG MFLADLIEKY
     FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG
     MSNFAYVKKE AGINDMFNFE TFGNSMICLF QITTSAGWDG LLAPILNSGP PDCDPKKVHP
     GSSVEGDCGN PSVGIFYFVS YIIISFLVVV NMYIAVILEN FSVATEESTE PLSEDDFEMF
     YEVWEKFDPD ATQFIEYSKL SDFAAALDPP LLIAKPNKVQ LIDMDLPTVS GVRIHCLDIL
     FAFTKRVLGE SGEMDSLRLQ MEERFMSANP SKVSYEPITT TLKRKQEDVS ATVIQRAYRR
     YRLRQNVKNI SSIYIKDGGK DDDLPKKEDT VFDNVNGNSS PEKTDATSST TSPPSYDSVT
     KPDKEKYEKD KTEKEDKGKD GKESKK
//
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