ID T0PAA4_AERSA Unreviewed; 862 AA.
AC T0PAA4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=kdpD {ECO:0000313|EMBL:ATP07284.1};
GN ORFNames=Asalp_00170 {ECO:0000313|EMBL:ATP07284.1};
OS Aeromonas salmonicida subsp. pectinolytica 34mel.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=1324960 {ECO:0000313|EMBL:ATP07284.1, ECO:0000313|Proteomes:UP000222916};
RN [1] {ECO:0000313|Proteomes:UP000222916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=34mel {ECO:0000313|Proteomes:UP000222916};
RX PubMed=29304740; DOI=10.1186/s12864-017-4301-6;
RA Pfeiffer F., Zamora-Lagos M.A., Blettinger M., Yeroslaviz A., Dahl A.,
RA Gruber S., Habermann B.H.;
RT "The complete and fully assembled genome sequence of Aeromonas salmonicida
RT subsp. pectinolytica and its comparative analysis with other Aeromonas
RT species: investigation of the mobilome in environmental and pathogenic
RT strains.";
RL BMC Genomics 19:20-20(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP022426; ATP07284.1; -; Genomic_DNA.
DR RefSeq; WP_021139876.1; NZ_CP022426.1.
DR AlphaFoldDB; T0PAA4; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000222916; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ATP07284.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ATP07284.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 640..857
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 862 AA; 94213 MW; B02F854FA15EAC68 CRC64;
MRDEARADAL LASLEQEHKG KLKVFLGAAP GVGKTYAMLQ AVREQAREGV DILIGVVETH
GRQETLALLD KLAIQPRKLH LHRQQRLEEM DLDALLARKP AIVVVDELAH SNAPGSRHEK
RWQDVEELLG AGIDVYSTLN VQHLESLNDL VWQLTGVRVK ETLPDQVLLE ADSIVLIDLP
PKELLGRLKE GKVYVPHQAK AALQSFFSLN NLTALRELAM QTAASHVEGD LQLQWQAAGK
TTLPLRGKLM VCLGDQHGSA LVRYGHRFAQ RRQLPWLVVH IDSKGQRSAE LEQALALASH
LGAKVLTLSS PAVASTLLET AEQQQVSQLL LGKPHKAPWR RSLVQHLLKQ AQGLEITLVD
TEKRKPGIGL QPLHPKDIRQ SLLAVTIMGL TSAAAWGLSH WLPPASLPLL FVLGVLATAL
TTSLVPAILA AVLGFVGHNL LFTAPYFSLS VASHSDLLTL FVLLIVGMTA GRLASRQRQQ
LVGLRETQQL GNALLSLSQG LATASSPEEV LRQGTQAISL ALAQPVFALD QDYQYRAGSA
QHNPGQTDKA AIDWCLAQKQ SAGAHTATLN AAEAQYHHLT DELILGIRLS NPLASSAEHQ
LQALLTDIRA ALARIDLNER LADSQLQAET DRMRAALLSS VSHDLKTPLA TIMGAGSTLL
EYGDRISPED RSELLHSVQD EARRLHSYVQ NLLDMTRIGS PDFQLKRDWV DLADLVESAR
KRLESSWRQH KLLVHFDQQI PQLYVHGALI EQVLVNILDN ASRYSPAGTP IEFKVMLADP
DLILDIIDIG VGIAESDRDK IFNLFYTQPV GDCGSRGTGL GLAISRAMIE AHGGRIWAFS
GPNGNGTCMR ISLPLALNAP EV
//
