ID T0PBX6_9CLOT Unreviewed; 912 AA.
AC T0PBX6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=M918_08620 {ECO:0000313|EMBL:EQB87448.1};
OS Clostridium sp. BL8.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1354301 {ECO:0000313|EMBL:EQB87448.1, ECO:0000313|Proteomes:UP000015873};
RN [1] {ECO:0000313|EMBL:EQB87448.1, ECO:0000313|Proteomes:UP000015873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BL8 {ECO:0000313|EMBL:EQB87448.1,
RC ECO:0000313|Proteomes:UP000015873};
RX PubMed=25076986; DOI=10.1186/1757-4749-6-30;
RA Marathe N.P., Shetty S.A., Lanjekar V.B., Rasane M.H., Ranade D.R.,
RA Shouche Y.S.;
RT "Genome sequencing of multidrug resistant novel Clostridium sp. BL8 reveals
RT its potential for pathogenicity.";
RL Gut Pathog. 6:30-30(2014).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB87448.1}.
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DR EMBL; AUPA01000192; EQB87448.1; -; Genomic_DNA.
DR RefSeq; WP_021283985.1; NZ_AUPA01000192.1.
DR AlphaFoldDB; T0PBX6; -.
DR STRING; 1354301.M918_08620; -.
DR PATRIC; fig|1354301.3.peg.2877; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000015873; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000015873}.
FT DOMAIN 688..704
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 912 AA; 103141 MW; 8BFE17FB396B3BD7 CRC64;
MALTPMMRQY LEVKDKCKDC ILFFRLGDFY EMFFEDAQVA SRELELTLTG RDCGLENKAP
MCGVPFHAAE NYISRLVSKG YKVAICEQVE DPAVAKGIVK RDIIKIVTPG TYTEGSFLQE
TKNNFIMSLY ITEDEKVGIC FCDISTGEFY CSETNYEESI IIDEICKFEP KEILLSEDLN
NNIIKTIEER FSISLSRFSN AAFSSDTEKL QAQFKNFNEI TLGQGVLKAC NGLLGYILET
QKISLTHIDE IELYNIFDYL TIDINSKRNL EIIESLRDKT KKGTLLWILD KTNTSMGARR
LKSWVEKPLV IKEEIHHRQE AIEELVNNLP LMEDLKEALK QIYDIERLVG KISSKNINAK
ELVALKQSIG KIPSVKELLA AANSKLLINI YNNLDELEDI YELLDSSLLE NPPLTIKEGN
IIKDGYHKEV DELRVAKTNG KQWIAALENS ERLDTGIKSL KVSYNKVFGY YIEITKANLS
SIPEGKYIRK QTLSNAERFI TPELKEMEDK ILGAEDKLMA LEYDLFVNVR DTIEVENHRM
KNTAKLISEL DCLYSLALIS KENNYCKPNI NNEGIITIEG GRHPVVEKML PVNTFVDNET
ELDTKDNQLI LITGPNMAGK STYMRQVALI TIMAQIGSFV PAKSANISIC DKIFTRIGAS
DDLAGGKSTF MVEMWEVSNI LKNATTRSLV LLDEVGRGTS TYDGLSIAWS VIEYICKTST
IRCKTLFATH YHELTKLEGE IPGVKNYSIA VKKIDNNIIF LRKIIRGGAD ESYGIEVGKL
AGLPSEVINR AKEILQVLED NNKECSSHNI IDNKKAYNEQ LVDEDKNLEA DSFKELSNRA
LSKKKNNKED KSNNEVATAL IKEEKLGPIQ IGFEDIATKN LLEEIKAVDV LNMTPMEGFN
KLYELINKAK KI
//
