ID T0PLC6_9CLOT Unreviewed; 516 AA.
AC T0PLC6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Flagellar hook-associated protein 2 {ECO:0000256|RuleBase:RU362066};
DE Short=HAP2 {ECO:0000256|RuleBase:RU362066};
DE AltName: Full=Flagellar cap protein {ECO:0000256|RuleBase:RU362066};
GN ORFNames=M918_03895 {ECO:0000313|EMBL:EQB88547.1};
OS Clostridium sp. BL8.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1354301 {ECO:0000313|EMBL:EQB88547.1, ECO:0000313|Proteomes:UP000015873};
RN [1] {ECO:0000313|EMBL:EQB88547.1, ECO:0000313|Proteomes:UP000015873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BL8 {ECO:0000313|EMBL:EQB88547.1,
RC ECO:0000313|Proteomes:UP000015873};
RX PubMed=25076986; DOI=10.1186/1757-4749-6-30;
RA Marathe N.P., Shetty S.A., Lanjekar V.B., Rasane M.H., Ranade D.R.,
RA Shouche Y.S.;
RT "Genome sequencing of multidrug resistant novel Clostridium sp. BL8 reveals
RT its potential for pathogenicity.";
RL Gut Pathog. 6:30-30(2014).
CC -!- FUNCTION: Required for morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|RuleBase:RU362066}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000256|ARBA:ARBA00011255,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362066}.
CC Bacterial flagellum {ECO:0000256|RuleBase:RU362066}.
CC -!- SIMILARITY: Belongs to the FliD family. {ECO:0000256|ARBA:ARBA00009764,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQB88547.1}.
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DR EMBL; AUPA01000098; EQB88547.1; -; Genomic_DNA.
DR RefSeq; WP_021282974.1; NZ_AUPA01000098.1.
DR AlphaFoldDB; T0PLC6; -.
DR STRING; 1354301.M918_03895; -.
DR PATRIC; fig|1354301.3.peg.1865; -.
DR OrthoDB; 9776025at2; -.
DR Proteomes; UP000015873; Unassembled WGS sequence.
DR GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:UniProtKB-UniRule.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR InterPro; IPR040026; FliD.
DR InterPro; IPR010809; FliD_C.
DR InterPro; IPR003481; FliD_N.
DR PANTHER; PTHR30288; FLAGELLAR CAP/ASSEMBLY PROTEIN FLID; 1.
DR PANTHER; PTHR30288:SF0; FLAGELLAR HOOK-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07195; FliD_C; 1.
DR Pfam; PF02465; FliD_N; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum {ECO:0000256|ARBA:ARBA00023143,
KW ECO:0000256|RuleBase:RU362066};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000015873};
KW Secreted {ECO:0000256|RuleBase:RU362066}.
FT DOMAIN 11..113
FT /note="Flagellar hook-associated protein 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02465"
FT DOMAIN 246..502
FT /note="Flagellar hook-associated protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07195"
SQ SEQUENCE 516 AA; 56573 MW; E5D2D16140B9900F CRC64;
MDKIRFGGMA SGLDTDTMVK QMMQPYRMKV DKVKQDKQTL QWKQDIYRDI IKDIRDLKSS
FFDNAKPENN LLSIKNYSAY NVTNKDSQVA TLSASTTGVL EGNYTVDVKS LAEPGKIVGG
VISNATRGTK LSDSAILGTI NATDSIKITI GTGTPIEVKV DDTSITLQQF ADKITTETKG
AAVARFSELT GEFVIETKET GANATISVAN GSGSLLSNFK ITTLSDTGVN GSVEVKDPSG
ATKLLSKESN NFTIDGVSYS LKGVGVSTTN ITPDSDKTFD KIVSFINKYN ELVDKVTKRT
EEKRQYSYSP LTEDQKKEMK EDEIKKWEEK AQEGLIKGDS SLKAMLSEMR LAFTDAVEGA
GISLKEIGFS TSKDTTQRGK IFLNDNLTPE DAKKKFSEVM KTKGSEVVNL FTKDGVDTKN
KGIVRRLDSI VEKYTSPFGE KGVLLKKAGL KGNSTENNNI LTDQIKEKDK VILNLEKSLA
AKENAYYLKF AQLEKAMNNM NSQSAWLAQQ LGGGKM
//
