ID T0SEW1_LACLC Unreviewed; 141 AA.
AC T0SEW1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 13-SEP-2023, entry version 36.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000256|HAMAP-Rule:MF_01555};
DE EC=5.3.1.26 {ECO:0000256|HAMAP-Rule:MF_01555};
GN Name=lacA {ECO:0000256|HAMAP-Rule:MF_01555};
GN ORFNames=LLT6_04320 {ECO:0000313|EMBL:EQC56951.1};
OS Lactococcus cremoris subsp. cremoris TIFN6.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus; Lactococcus cremoris subsp. cremoris.
OX NCBI_TaxID=1234876 {ECO:0000313|EMBL:EQC56951.1, ECO:0000313|Proteomes:UP000015854};
RN [1] {ECO:0000313|EMBL:EQC56951.1, ECO:0000313|Proteomes:UP000015854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TIFN6 {ECO:0000313|EMBL:EQC56951.1,
RC ECO:0000313|Proteomes:UP000015854};
RX PubMed=23823494; DOI=10.1038/ismej.2013.108;
RA Erkus O., de Jager V.C., Spus M., van Alen-Boerrigter I.J.,
RA van Rijswijck I.M., Hazelwood L., Janssen P.W., van Hijum S.A.,
RA Kleerebezem M., Smid E.J.;
RT "Multifactorial diversity sustains microbial community stability.";
RL ISME J. 7:2126-2136(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_01555};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family.
CC {ECO:0000256|ARBA:ARBA00008754, ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQC56951.1}.
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DR EMBL; ATBB01000231; EQC56951.1; -; Genomic_DNA.
DR AlphaFoldDB; T0SEW1; -.
DR SMR; T0SEW1; -.
DR PATRIC; fig|1234876.3.peg.1032; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000015854; Unassembled WGS sequence.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR HAMAP; MF_01555; LacA; 1.
DR InterPro; IPR004783; LacA.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR NCBIfam; TIGR01118; lacA; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR30345:SF5; GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNIT LACA; 1.
DR PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01555, ECO:0000313|EMBL:EQC56951.1};
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736, ECO:0000256|HAMAP-
KW Rule:MF_01555}; Reference proteome {ECO:0000313|Proteomes:UP000015854}.
SQ SEQUENCE 141 AA; 15236 MW; 9C2EA129C6FEFF13 CRC64;
MAIVVGADLK GTRLKDVVKN FLVEEGFEVI DVTKDGQDFV DVTLAVASEV NKDEQNLGIV
IDAYGAGPFM VATKIKGMVA AEVSDERSAY MTRGHNNARM ITVGAEIVGD ELAKNIAKAF
VNGKYDGGRH QVRVDMLNKM C
//
