ID   T0TST8_9STRE            Unreviewed;       382 AA.
AC   T0TST8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Epoxyqueuosine (OQ) reductase QueG {ECO:0000313|EMBL:EQC76360.1};
GN   ORFNames=HSISM1_1979 {ECO:0000313|EMBL:EQC76360.1};
OS   Streptococcus sp. HSISM1.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1316408 {ECO:0000313|EMBL:EQC76360.1};
RN   [1] {ECO:0000313|EMBL:EQC76360.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HSISM1 {ECO:0000313|EMBL:EQC76360.1};
RA   Van den Bogert B., Boekhorst J., Herrmann R., Smid E.J., Zoetendal E.G.,
RA   Kleerebezem M.;
RT   "Comparative Genomics Analysis of Streptococcus Isolates from the Human
RT   Small Intestine Reveals their Adaptation to a Highly Dynamic Ecosystem.";
RL   PLoS ONE 8:E83418-E83418(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQC76360.1}.
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DR   EMBL; ASKI01000069; EQC76360.1; -; Genomic_DNA.
DR   AlphaFoldDB; T0TST8; -.
DR   PATRIC; fig|1316408.3.peg.1530; -.
DR   eggNOG; COG1600; Bacteria.
DR   HOGENOM; CLU_030790_2_0_9; -.
DR   Proteomes; UP000015933; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR004453; QueG.
DR   InterPro; IPR013542; QueG_DUF1730.
DR   NCBIfam; TIGR00276; tRNA epoxyqueuosine(34) reductase QueG; 1.
DR   PANTHER; PTHR30002; EPOXYQUEUOSINE REDUCTASE; 1.
DR   PANTHER; PTHR30002:SF4; EPOXYQUEUOSINE REDUCTASE; 1.
DR   Pfam; PF13484; Fer4_16; 1.
DR   Pfam; PF08331; QueG_DUF1730; 1.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Queuosine biosynthesis {ECO:0000256|ARBA:ARBA00022785};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          179..207
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   382 AA;  42676 MW;  20F10ED2A2D3B28E CRC64;
     MEKMTLKENI IQLAHSIGIS KIGFTTADDF AYLEKSLRLA VEEGRNSGFE HKNIEERIHP
     KLSLSSAKTI ISIAVAYPHK LKQQPQKTTY KRGKFTPNSW GLDYHYVLQD KLNRLAAGIE
     EMTQDFEYKG MVDTGALVDT AVAQRAGIGF IGKNGLVISK EYGSYMFLGE LITNLEIEPD
     QPVDYGCGDC RRCLDACPTS CLIGDGSMNA KRCLSFQTQD KGMMDLEFRK KIKTVIYGCD
     ICQISCPYNK GLDNPLATEI DPDLAHPELI PFIELSNGQF KEKFGNVAGS WRGKNILQRN
     AIIALANAND RSAIPKLLNI IETSQNQIHI ATAIWSLGQL LREVTPDLVE LLRNIKHPTD
     AIIEERTAFF EKFGIQAVSQ LQ
//