ID   T0VCG7_9STRE            Unreviewed;       184 AA.
AC   T0VCG7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Biotin-protein ligase / Biotinoperon repressor {ECO:0000313|EMBL:EQC77218.1};
DE            EC=6.3.4.15 {ECO:0000313|EMBL:EQC77218.1};
GN   ORFNames=HSISM1_1589 {ECO:0000313|EMBL:EQC77218.1};
OS   Streptococcus sp. HSISM1.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1316408 {ECO:0000313|EMBL:EQC77218.1};
RN   [1] {ECO:0000313|EMBL:EQC77218.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HSISM1 {ECO:0000313|EMBL:EQC77218.1};
RA   Van den Bogert B., Boekhorst J., Herrmann R., Smid E.J., Zoetendal E.G.,
RA   Kleerebezem M.;
RT   "Comparative Genomics Analysis of Streptococcus Isolates from the Human
RT   Small Intestine Reveals their Adaptation to a Highly Dynamic Ecosystem.";
RL   PLoS ONE 8:E83418-E83418(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQC77218.1}.
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DR   EMBL; ASKI01000051; EQC77218.1; -; Genomic_DNA.
DR   AlphaFoldDB; T0VCG7; -.
DR   PATRIC; fig|1316408.3.peg.1148; -.
DR   eggNOG; COG0340; Bacteria.
DR   eggNOG; COG1654; Bacteria.
DR   HOGENOM; CLU_1467401_0_0_9; -.
DR   Proteomes; UP000015933; Chromosome.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProt.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   CDD; cd16442; BPL; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR013196; HTH_11.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF08279; HTH_11; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EQC77218.1}.
FT   DOMAIN          71..184
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   184 AA;  20609 MW;  0B6541C9F900515D CRC64;
     MKTHEILFQT LSQADDYVNG EQLAKELGVS RTSIWKAIQR LEKDGVVIES LKKKGYRLVS
     GDILLPEVIA SNTQLTVTLN EECHSTQLDA KLGMEAHKEG RALYLATSQS AGKGRFGRDY
     YSPDQGGIYM SLHLKPQLPP AELPPYTLMV AGAIYKAIKN LTLIDVDIKW VNDIYYRHKK
     LGES
//