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Database: UniProt
Entry: T0ZJ01_9ZZZZ
LinkDB: T0ZJ01_9ZZZZ
Original site: T0ZJ01_9ZZZZ 
ID   T0ZJ01_9ZZZZ            Unreviewed;       108 AA.
AC   T0ZJ01;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   22-FEB-2023, entry version 15.
DE   RecName: Full=porphobilinogen synthase {ECO:0000256|ARBA:ARBA00012053};
DE            EC=4.2.1.24 {ECO:0000256|ARBA:ARBA00012053};
DE   AltName: Full=Porphobilinogen synthase {ECO:0000256|ARBA:ARBA00032837};
DE   Flags: Fragment;
GN   ORFNames=B2A_14816 {ECO:0000313|EMBL:EQD28689.1};
OS   mine drainage metagenome.
OC   unclassified sequences; metagenomes; ecological metagenomes.
OX   NCBI_TaxID=410659 {ECO:0000313|EMBL:EQD28689.1};
RN   [1] {ECO:0000313|EMBL:EQD28689.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mendez C., Richter M., Ferrer M., Sanchez J.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EQD28689.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24430486; DOI=10.1038/ismej.2013.242;
RA   Mendez-Garcia C., Mesa V., Sprenger R.R., Richter M., Diez M.S., Solano J.,
RA   Bargiela R., Golyshina O.V., Manteca A., Ramos J.L., Gallego J.R.,
RA   Llorente I., Martins Dos Santos V.A., Jensen O.N., Pelaez A.I., Sanchez J.,
RA   Ferrer M.;
RT   "Microbial stratification in low pH oxic and suboxic macroscopic growths
RT   along an acid mine drainage.";
RL   ISME J. 8:1259-1274(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen;
CC         Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00001227};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004694}.
CC   -!- SIMILARITY: Belongs to the ALAD family.
CC       {ECO:0000256|ARBA:ARBA00008055}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQD28689.1}.
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DR   EMBL; AUZZ01010771; EQD28689.1; -; Genomic_DNA.
DR   AlphaFoldDB; T0ZJ01; -.
DR   UniPathway; UPA00251; UER00318.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004655; F:porphobilinogen synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR001731; ALAD.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   PANTHER; PTHR11458; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   PANTHER; PTHR11458:SF0; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   Pfam; PF00490; ALAD; 1.
DR   SMART; SM01004; ALAD; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EQD28689.1"
SQ   SEQUENCE   108 AA;  12104 MW;  6A0E79314A821DA3 CRC64;
     LIMPVFVDEN LKEPKKIDTM PGILRLPLAA LEEYFGRLED LGIRSVLMFG IPKSKDAMGT
     SAYDPEGVVQ KALKICDESS RLISIADLCL CEYTDQWALR ARSGRKSR
//
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