ID   T1D8F8_CROHD            Unreviewed;       924 AA.
AC   T1D8F8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   22-FEB-2023, entry version 24.
DE   SubName: Full=Sorting nexin-14-like protein {ECO:0000313|EMBL:JAA95549.1};
OS   Crotalus horridus (Timber rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=35024 {ECO:0000313|EMBL:JAA95549.1};
RN   [1] {ECO:0000313|EMBL:JAA95549.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Venom gland {ECO:0000313|EMBL:JAA95549.1};
RX   PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA   Rokyta D.R., Wray K.P., Margres M.J.;
RT   "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT   (Crotalus horridus) revealed through comparative venom-gland
RT   transcriptomics.";
RL   BMC Genomics 14:394-394(2013).
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   EMBL; GAAZ01002394; JAA95549.1; -; mRNA.
DR   AlphaFoldDB; T1D8F8; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          130..304
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          349..468
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          560..680
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   924 AA;  108074 MW;  880ACC6AC80EFE6E CRC64;
     MRWARAAVER LCQRARRVDF LRETCRQYPL FCCIFLGFSV ATLLLSRYRH ILMIFWSFVA
     GFVTFYCYLG PDTLLPNILF TIKQKSKQLK LQEQSSQNGS CAICGDIKCS RHGPASLLED
     YQPWLGLKVP SKVDTSLSEM FELVLENFIY PWYRQITDDE SSVDELRVTL RFFASVLLRR
     IYKVNIPTVT TTKMLKAAMK HIEVIAKARQ KVKNTEYLQQ AALEEYGPSL HVALRSRRDE
     LNYLRKLTEL LFSYILLPKA TDCGTFTLLI REILSGSVFL PSMDYLADPD TVNHLILIFI
     DDRPPEIATE PASPLVPFLQ KFAEPRSKKS SALHFELKEF EDKQDLFFLF MSFLKKEGKV
     HVLQFYLELE QFNNRILQAE LSDSEKMSLH EEVKKIYETY CLDESIDKIK FDSFIVEEIQ
     SIAEGPYKEV VKLQQMRCFF EAYEQVFSLL ENVFIPKFCH TYEYFKHLFQ EVESPTRNSK
     SNKSMHRRES SGIRSISSKI KGVFKSTTME GAVLPDYLLA EGEDDFIEEG IMVMEDDSPV
     EALSMPNTPR NLAAWKITIP YVDFFEDPSL EKKERRERIP VFCIDVERND RLAIGHKPEH
     WSVYRRYFEF YVLESKLTEF HGAFPDAQLP SKRIIGPKNY EFLKSKREEF QEYLQKLSQH
     PELSNSQLLA DFLSRNGGET QFLDKILPDV NLGKIIKSVP GKLMKEKGQH LEPFIINFIT
     SCESPKPKPS KPEITILSPT SENNKKLYNE LYKNNANRSE NLERRQNENY FLKMMTIEGV
     YDFLMYIARV VFHIPDWLHH ILMGGRILFK NTLEKYIDNY LQYKLEQLFQ EHRLVSLITL
     LRDAVFCENS QPRSLQDKHK RAKQTFEEMM KYIPDLIGKC IGEDAKYEGI RLLFDGLQQP
     VLNKQLTYVL LDIGIQELFP ELNV
//