ID T1DMV4_CROHD Unreviewed; 318 AA.
AC T1DMV4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Heme oxygenase 2-like protein {ECO:0000313|EMBL:JAA96881.1};
OS Crotalus horridus (Timber rattlesnake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX NCBI_TaxID=35024 {ECO:0000313|EMBL:JAA96881.1};
RN [1] {ECO:0000313|EMBL:JAA96881.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAA96881.1};
RX PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA Rokyta D.R., Wray K.P., Margres M.J.;
RT "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT (Crotalus horridus) revealed through comparative venom-gland
RT transcriptomics.";
RL BMC Genomics 14:394-394(2013).
RN [2] {ECO:0000313|EMBL:JAG44495.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type B {ECO:0000313|EMBL:JAG46663.1};
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAG44495.1};
RX PubMed=25727380; DOI=10.1016/j.toxicon.2015.02.015;
RA Rokyta D.R., Wray K.P., McGivern J.J., Margres M.J.;
RT "The transcriptomic and proteomic basis for the evolution of a novel venom
RT phenotype within the Timber Rattlesnake (Crotalus horridus).";
RL Toxicon 98:34-48(2015).
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DR EMBL; GAAZ01001062; JAA96881.1; -; mRNA.
DR EMBL; GBKC01001575; JAG44495.1; -; Transcribed_RNA.
DR EMBL; GBKD01000955; JAG46663.1; -; Transcribed_RNA.
DR AlphaFoldDB; T1DMV4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004392; F:heme oxygenase (decyclizing) activity; IEA:InterPro.
DR GO; GO:0006788; P:heme oxidation; IEA:InterPro.
DR CDD; cd19165; HemeO; 1.
DR Gene3D; 1.20.910.10; Heme oxygenase-like; 1.
DR InterPro; IPR002051; Haem_Oase.
DR InterPro; IPR016053; Haem_Oase-like.
DR InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR PANTHER; PTHR10720; HEME OXYGENASE; 1.
DR PANTHER; PTHR10720:SF2; HEME OXYGENASE 2; 1.
DR Pfam; PF01126; Heme_oxygenase; 1.
DR PRINTS; PR00088; HAEMOXYGNASE.
DR SUPFAM; SSF48613; Heme oxygenase-like; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..34
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 36276 MW; EF664B31E13C59AF CRC64;
MSTEAAELMD EPESHSYEEE EEEEEEEEEE NTSPTDLSEL LKEGTKEAHD RAENTQFVKD
FLKGRIKREL FKLGTAALYF TYCALEEEME HNKDQPSFTP LYFPLELHRK EALARDLEYL
YGEGWEEKIQ CSEATQRYVD RIHHVGQHEP ELLVSHAYTR YMGDLSGGQV LKRVAQRALK
LPSTGEGINF YMFENISNPQ QFKQFYRARL NALDVSQETK ERIVKEANRA FEFNMQVFEE
LDKIGALLPE EAQDGGLPMH DGKGDMRKCP YYASKPAGSK DTACPCHLAL AALKQPTVQL
VLAACVAVTA GIAAWYVM
//
