ID T1E4Y5_CROHD Unreviewed; 162 AA.
AC T1E4Y5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Sorting nexin-12 {ECO:0000313|EMBL:JAA96338.1};
OS Crotalus horridus (Timber rattlesnake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX NCBI_TaxID=35024 {ECO:0000313|EMBL:JAA96338.1};
RN [1] {ECO:0000313|EMBL:JAA96338.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAA96338.1};
RX PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA Rokyta D.R., Wray K.P., Margres M.J.;
RT "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT (Crotalus horridus) revealed through comparative venom-gland
RT transcriptomics.";
RL BMC Genomics 14:394-394(2013).
RN [2] {ECO:0000313|EMBL:JAG43711.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type B {ECO:0000313|EMBL:JAG46186.1};
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAG43711.1};
RX PubMed=25727380; DOI=10.1016/j.toxicon.2015.02.015;
RA Rokyta D.R., Wray K.P., McGivern J.J., Margres M.J.;
RT "The transcriptomic and proteomic basis for the evolution of a novel venom
RT phenotype within the Timber Rattlesnake (Crotalus horridus).";
RL Toxicon 98:34-48(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; GAAZ01001605; JAA96338.1; -; mRNA.
DR EMBL; GBKC01002359; JAG43711.1; -; Transcribed_RNA.
DR EMBL; GBKD01001432; JAG46186.1; -; Transcribed_RNA.
DR AlphaFoldDB; T1E4Y5; -.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd07294; PX_SNX12; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR45963; RE52028P; 1.
DR PANTHER; PTHR45963:SF2; SORTING NEXIN-12; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 2: Evidence at transcript level;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT DOMAIN 28..152
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 162 AA; 18901 MW; ACE99A3580630589 CRC64;
MSEAAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARYTSY ELRMRTNLPI
FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR
QGLEQFINKI AGHPLAQNER CLHMFLQDET IDRNYVPGKV RQ
//
